South Texas Alzheimer’s and Neurodegenerative Disorders Training Program

南德克萨斯阿尔茨海默病和神经退行性疾病培训计划

• 批准号: 10713507
• 负责人: Jose E Cavazos
• 金额: $ 13.28万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713507
• 关键词: Alzheimer' s Disease; Neurodegenerative Disorders; South Texas; Training Programs

A predoctoral T32 training program is proposed to augment the research workforce in Alzheimer’s Disease (AD), related dementias (RD) and other neurodegenerative disorders (ND). The training initiative is named the South Texas Alzheimer’s and Neurodegenerative Disorders Training Program: STAND TP. STAND TP is hosted by UT Health San Antonio (UTHSA), a Hispanic Serving Institution which plays a dominant role in health-care delivery to the residents of San Antonio and greater South Texas, the majority of whom are Hispanic. The overall goal of the STAND TP is to develop a diverse, computationally sophisticated, translational and cross-disciplinary research workforce to become leaders and members of cross-disciplinary research programs in AD, RD and ND. Modern medical science is team based and translational, with a workflow spanning orders of bioscale from genetics and molecular biology to systems physiology and health-care delivery. In the neurosciences, computer- based methods – including imaging, genetics, multi-omics and epidemiology – have become fundamental to the discovery process at preclinical and clinical levels, being used both as investigative tools and as biomarkers for staging study participants and as surrogate outcomes for assessing treatment efficacy. In tandem, computational approaches to image analytics have expanded in power and scope of application with the rapidly increasing availability of high-performance computer clusters and cloud computing. The future AD/RD/ND workforce needs expertise in all of these domains. To achieve the envisioned scope of expertise, STAND TP draws from four, well-established, PhD-granting programs: Integrated Biomedical Sciences (IBMS), Radiological Sciences (RADI), Biomedical Engineering (BME), and Translational Sciences (TS). Collectively, these four, thematically diverse programs enroll 40-50 doctoral-degree trainees per year, eight of whom are MD/PhD trainees from our T32-funded Medical Scientist Training Program. From this 4-program pool, STAND TP will recruit post- candidacy, pre-doctoral students who propose dissertation research topics in AD, RD or ND. Eligible applicants must be mentored by faculty investigators with expertise in AD/RD/ND and who have adequate funding to support the proposed research. The UTHSA AD/RD/ND research community is large and well-funded, commensurate with a longstanding, stable portfolio of NIH/NIA funding. UTHSA hosts three NIA P30 awards: an Alzheimer’s Disease Research Center, a Nathan Shock Center, and a Pepper Center. Most P30-affiliated faculty have individual awards from NIA and other NIH institutes. Beyond the scope of each doctoral program, STAND TP mandates cross-disciplinary training including: coursework; a cross-disciplinary research experience via an innovative Core Clerkship program; and, scientific congress attendance. Training resources in the responsible conduct of research (RCR) and in methods to enhance scientific rigor and reproducibility (R&R) are well developed and mature. STAND TP is administrated by two PD/PIs, both of whom are ADRC core leaders, experienced training grant administers, and highly successful investigators and mentors.

提出了一个博士前T32培训计划，以增加阿尔茨海默病（AD）的研究队伍， 相关痴呆（RD）和其他神经退行性疾病（ND）。该培训计划被命名为南方 得克萨斯州阿尔茨海默氏症和神经退行性疾病培训计划：STAND TP。STAND TP由 UT健康圣安东尼奥（UTHSA），西班牙裔服务机构，在医疗保健中发挥主导作用 交付给圣安东尼奥和大南德克萨斯州的居民，其中大多数是西班牙裔。整体 STAND TP的目标是开发一个多样化的、计算复杂的、翻译的和跨学科的 研究队伍成为领导者和跨学科研究计划的成员在AD，RD和 ND.现代医学科学是基于团队的和转化的，其工作流程跨越了从 从遗传学和分子生物学到系统生理学和保健服务。在神经科学中，计算机- 包括成像、遗传学、多组学和流行病学在内的基础方法已经成为 在临床前和临床水平的发现过程中，被用作研究工具和生物标志物， 对研究参与者进行分期，并作为评估治疗疗效的替代结局。在串联，计算 图像分析的方法已经在能力和应用范围上扩展， 提供高性能计算机集群和云计算。未来的AD/RD/ND劳动力需求 所有这些领域的专业知识。为了实现预期的专业范围，STAND TP从四个方面汲取经验， 完善的，博士授予计划：综合生物医学科学（IBMS），放射科学 （RADI），生物医学工程（BME）和转化科学（TS）。总的来说，这四个主题 每年招收40-50名博士学位学员，其中8名是来自我们的MD/PhD学员。 T32资助的医学科学家培训计划。从这4个程序池，STAND TP将招募后- 候选人，在AD，RD或ND提出论文研究课题的博士前学生。合资格的申请人 必须由具有AD/RD/ND专业知识的教师研究人员指导，他们有足够的资金， 支持拟议的研究。UTHSA AD/RD/ND研究社区规模庞大，资金充足， 与NIH/NIA长期稳定的资金组合相称。UTHSA主办三个NIA P30奖项： 阿尔茨海默病研究中心，内森休克中心和胡椒中心。大多数P30附属教师 获得NIA和其他NIH机构的个人奖项。除了每个博士课程的范围，站 TP授权跨学科培训，包括：课程;通过跨学科研究经验， 创新的核心职员计划;和，科学会议出席。负责人的培训资源 研究的进行（RCR）和方法，以提高科学的严谨性和再现性（R&R）是很好的 发达和成熟。STAND TP由两名PD/PI管理，他们都是ADRC的核心领导人， 经验丰富的培训补助金管理员，以及非常成功的调查员和导师。