South Texas Alzheimer’s and Neurodegenerative Disorders Training Program

南德克萨斯阿尔茨海默病和神经退行性疾病培训计划

• 批准号: 10713507
• 负责人: Jose E Cavazos
• 金额: $ 13.28万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713507
• 关键词: Alzheimer' s Disease; Neurodegenerative Disorders; South Texas; Training Programs

A predoctoral T32 training program is proposed to augment the research workforce in Alzheimer’s Disease (AD), related dementias (RD) and other neurodegenerative disorders (ND). The training initiative is named the South Texas Alzheimer’s and Neurodegenerative Disorders Training Program: STAND TP. STAND TP is hosted by UT Health San Antonio (UTHSA), a Hispanic Serving Institution which plays a dominant role in health-care delivery to the residents of San Antonio and greater South Texas, the majority of whom are Hispanic. The overall goal of the STAND TP is to develop a diverse, computationally sophisticated, translational and cross-disciplinary research workforce to become leaders and members of cross-disciplinary research programs in AD, RD and ND. Modern medical science is team based and translational, with a workflow spanning orders of bioscale from genetics and molecular biology to systems physiology and health-care delivery. In the neurosciences, computer- based methods – including imaging, genetics, multi-omics and epidemiology – have become fundamental to the discovery process at preclinical and clinical levels, being used both as investigative tools and as biomarkers for staging study participants and as surrogate outcomes for assessing treatment efficacy. In tandem, computational approaches to image analytics have expanded in power and scope of application with the rapidly increasing availability of high-performance computer clusters and cloud computing. The future AD/RD/ND workforce needs expertise in all of these domains. To achieve the envisioned scope of expertise, STAND TP draws from four, well-established, PhD-granting programs: Integrated Biomedical Sciences (IBMS), Radiological Sciences (RADI), Biomedical Engineering (BME), and Translational Sciences (TS). Collectively, these four, thematically diverse programs enroll 40-50 doctoral-degree trainees per year, eight of whom are MD/PhD trainees from our T32-funded Medical Scientist Training Program. From this 4-program pool, STAND TP will recruit post- candidacy, pre-doctoral students who propose dissertation research topics in AD, RD or ND. Eligible applicants must be mentored by faculty investigators with expertise in AD/RD/ND and who have adequate funding to support the proposed research. The UTHSA AD/RD/ND research community is large and well-funded, commensurate with a longstanding, stable portfolio of NIH/NIA funding. UTHSA hosts three NIA P30 awards: an Alzheimer’s Disease Research Center, a Nathan Shock Center, and a Pepper Center. Most P30-affiliated faculty have individual awards from NIA and other NIH institutes. Beyond the scope of each doctoral program, STAND TP mandates cross-disciplinary training including: coursework; a cross-disciplinary research experience via an innovative Core Clerkship program; and, scientific congress attendance. Training resources in the responsible conduct of research (RCR) and in methods to enhance scientific rigor and reproducibility (R&R) are well developed and mature. STAND TP is administrated by two PD/PIs, both of whom are ADRC core leaders, experienced training grant administers, and highly successful investigators and mentors.

一项博士前T32培训计划被提出，以增加阿尔茨海默病(AD)的研究队伍， 相关痴呆(RD)和其他神经退行性疾病(ND)。培训计划被命名为南方 德克萨斯州阿尔茨海默氏症和神经退行性疾病培训计划：STAND TP。Stand TP由托管 UT Health San Antonio(UTHSA)，一家在医疗保健领域发挥主导作用的拉美裔服务机构 递送给圣安东尼奥和南得克萨斯州的居民，他们中的大多数是西班牙裔。整体而言 展台TP的目标是开发一种多样化的、计算复杂的、翻译的和跨学科的 研究人员将成为AD、RD和 然后。现代医学是基于团队和翻译的，工作流跨越了来自 从遗传学和分子生物学到系统生理学和医疗保健服务。在神经科学方面，计算机- 以成像、遗传学、多组学和流行病学为基础的方法已经成为 临床前和临床层面的发现过程，既被用作研究工具，也被用作 对研究参与者进行分期，作为评估治疗效果的替代结果。同时，计算性的 随着图像分析的快速增长，图像分析的方法在功能和应用范围上都得到了扩展 高性能计算机集群和云计算的可用性。未来AD/RD/ND劳动力需求 所有这些领域的专业知识。为了实现预期的专业知识范围，Stand TP从四个方面进行了总结， 成熟的、授予博士学位的项目：综合生物医学科学(IBMS)、放射科学 (RADI)、生物医学工程(BME)和翻译科学(TS)。总而言之，这四个人，按主题 不同的项目每年招收40-50名博士实习生，其中8人是我们的医学博士/博士实习生 T32资助的医学科学家培训计划。从这4个项目池中，Stand TP将招聘以下职位： 提出AD、RD或ND学位论文研究主题的博士生。符合条件的申请者 必须由具有AD/RD/ND专业知识并有足够资金的教员调查人员进行指导 支持拟议的研究。UTHSA AD/RD/ND研究社区规模庞大且资金充足， 与NIH/NIA长期稳定的资金组合相称。UTHSA主办三个NIA P30奖项： 阿尔茨海默氏症研究中心、内森休克中心和胡椒中心。大多数与P30相关的教职员工 拥有NIA和其他NIH研究所颁发的个人奖项。超出每个博士项目的范围， TP要求进行跨学科培训，包括：课程作业；通过 创新核心文员计划；科学出席大会。负责部门的培训资源 研究行为(RCR)和提高科学严谨性和重复性的方法(R&R)很好 发达和成熟。TP站由两个PD/PI管理，这两个人都是ADRC的核心领导人， 经验丰富的培训基金管理人员，以及非常成功的调查人员和导师。