Decoding Microbial Diversity in the Human Gut Microbiome
解码人类肠道微生物组中的微生物多样性
基本信息
- 批准号:10713170
- 负责人:
- 金额:$ 38.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAnimal ModelAnti-Bacterial AgentsAntimalarialsAutoimmune DiseasesBig DataBile AcidsBiologicalCommunicable DiseasesCommunitiesComplexComputational BiologyCoupledDataEquilibriumFamilyGastrointestinal tract structureGenetic VariationGenomeGenotypeGnotobioticGoalsHealthHigh-Throughput Nucleotide SequencingHumanHuman MicrobiomeLibrariesMalignant NeoplasmsMedicineMetabolicMetabolic PathwayMicrobeMissionOral AdministrationOrganismOutputPathway interactionsPharmaceutical PreparationsPhenotypePhylogenetic AnalysisPhysiologyResearchResourcesShapesSumTherapeuticVariantbile acid metabolismcomparative genomicsfecal transplantationgene discoverygut microbiomehost microbiomehost-microbe interactionslaboratory experimentmicrobialmicrobial communitymicrobiome researchmodel organismprogramsrational designresponsetooltranslational applicationstransplantation therapy
项目摘要
PROJECT SUMMARY / ABSTRACT
The ecological concept of diversity is deceptively simple: what organisms are present and how are they
distributed. The advent of high-throughput sequencing enabled more than a decade of observational human
microbiome studies; however, these studies frequently established correlation, but not causation, between
microbial diversity and health. Through mechanistic research, I and others have shown the significance of strain
variation, i.e. phenotypic and genotypic variation within a species, in host-microbiome interactions; however,
most of our understanding comes from a limited range of model organisms which poorly represent the large
diversity observed in the human gastrointestinal tract. Rather than view strain diversity as a limitation and caveat
in microbiome research, my group takes a fundamentally different approach: we exploit it as a tool for
mechanistic research. The mission of my research program is to understand how our microbial communities
shape human health and physiology. We do this through leveraging computational biology and big data with wet
lab experiments including gnotobiotic animal models to balance reductionism and biological relevance. The
research themes in this proposal ask discrete questions about the interface of host and microbe but are unified
in their approach of using naturally occurring strain variation coupled to comparative genomics as a tool for gene
discovery in a reference panel of >300 genome sequenced bacterial isolates. Theme I will ask a fundamental
question: can we leverage 10 years of publicly available data to rationally design functional synthetic
communities? These consortia will act as both tools for understanding the assembly and function of complex
communities, and will have translational applications as alternatives to human fecal transplant therapy. Theme
II will focus on deconvoluting the shared host and microbial metabolism of bile acids (BAs), a family of
compounds with broad relevance to infectious and autoimmune diseases, cancer, and metabolic health. Despite
their importance, the microbial metabolic pathways of BA metabolism and their phylogenetic distribution are
poorly characterized. Through comprehensive analysis of our strain library and synthetic communities derived
thereof, we will determine the origins of biologically significant BAs. Understanding these trans-species pathways
will address an important question: can we predict the metabolic output of a community based on the sum of its
parts? Theme III addresses an urgent question in medicine: how does microbial strain-variation contribute to
interpersonal variation in drug response? We are now working on a new class of important orally administered
drugs which were not previously known to interact with the gut microbiome: antimalarials. Building on preliminary
data demonstrating off-target strain-variable antibacterial effects, we will characterize how bacterial interactions
with antimalarials affect therapeutic efficiency. These themes have a shared and unified goal: to generate both
resources and fundamental understanding of host-microbe interactions leading to translational applications.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jordan Adam Bisanz其他文献
Jordan Adam Bisanz的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jordan Adam Bisanz', 18)}}的其他基金
Diet-microbe interactions modulating host energy balance
饮食-微生物相互作用调节宿主能量平衡
- 批准号:
10478121 - 财政年份:2021
- 资助金额:
$ 38.3万 - 项目类别:
Diet-microbe interactions modulating host energy balance
饮食-微生物相互作用调节宿主能量平衡
- 批准号:
10435693 - 财政年份:2021
- 资助金额:
$ 38.3万 - 项目类别:
Diet-microbe interactions modulating host energy balance
饮食-微生物相互作用调节宿主能量平衡
- 批准号:
9976879 - 财政年份:2020
- 资助金额:
$ 38.3万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 38.3万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 38.3万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 38.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 38.3万 - 项目类别:
Studentship














{{item.name}}会员




