Effect of Human Milk Oligosaccharide-based synbiotics on neurodevelopment of HIV-exposeduninfected children

母乳低聚糖合生元对 HIV 暴露未感染儿童神经发育的影响

• 批准号: 10712590
• 负责人: Rupak Shivakoti
• 金额: $ 35.2万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10712590
• 关键词: Address; African; Age Months; Animal Model; Area; Attention; Behavior; Biological; Child; Cognition; Cognitive; Communication; Country; Data; Data Analyses; Development; Emotional; Foundations; Funding; Goals; Grant; Growth; HIV; HIV Infections; HIV-exposed uninfected infant; Hearing; Human; Human Milk; Impairment; Infant; Infant Health; Intervention; Laboratories; Language; Language Delays; Learning; Life; Link; Literature; Memory; Methods; Morbidity - disease rate; Motor; Observational Study; Oligosaccharides; Outcome; Parents; Pathway interactions; Placebos; Postpartum Period; Probiotics; Questionnaires; Randomized; Randomized, Controlled Trials; Reporting; Research Personnel; Resource-limited setting; Resources; Rodent Model; Socialization; South Africa; South African; Spain; Speech; Testing; Time; Vision; animal data; cognitive development; data modeling; effective intervention; experience; eye hand coordination; gut microbiome; high risk; human data; improved; infant gut microbiome; intervention effect; multiple datasets; neurodevelopment; parent project; randomized trial; screening; social; study population; tool; trial design

ABSTRACT This is a request for supplement funding to the MIGH-T MO study (i.e. R01HD105492 titled: “Trial of Human Milk Oligosaccharide-based synbiotics for HIV-exposed uninfected children”) being conducted in South Africa. This supplement study is related to the parent study aims of studying the effect of the intervention on outcomes of growth and morbidity, by focusing on neurodevelopment. Neurodevelopment is an important part of growth and morbidity, thus relevant to the parent study aims. Of relevance to the parent study population of children who are HIV-exposed uninfected (CHEU), there is data from multiple settings including South Africa that show impaired neurodevelopment in CHEU compared to children who are HIV-unexposed uninfected (CHUU), and an intervention to improve neurodevelopment outcomes are currently lacking for CHEU. Importantly, animal model data and observational data from humans suggest that certain human milk oligosaccharides, such as 2’- Fucosyllactose being used in this study, are positively associated with neurodevelopment. Thus, our study provides an important opportunity to test the effect of the human milk oligosaccharide-based intervention on CHEU neurodevelopment using a randomized trial design. Overall, we hypothesize that the intervention will improve neurodevelopment in CHEU. Our findings would inform on whether the synbiotic could be an effective intervention to reduce growth deficits and morbidity, as they relate to neurodevelopment, in CHEU.

摘要

项目成果

Feasibility Study of a Powder-Based Supplement Intervention for a future Synbiotic Trial in Breastfed Children from South Africa.

针对南非母乳喂养儿童未来合生试验的粉末补充剂干预的可行性研究。

• DOI: 10.21203/rs.3.rs-2842773/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Shivakoti,Rupak;Laughton,Barbara;Shafiq,Mehr;Schoeman,Elisma;Glashoff,RichardH;Barnabas,Shaun;Fry,Samantha;Leu,Cheng-Shiun;Wang,Shuang;Bode,Lars;Aldrovandi,Grace;Kuhn,Louise;Slogrove,AmyL
• 通讯作者: Slogrove,AmyL