Oncology Research Training Grant

摘要 肿瘤学研究培训计划(ORTP)已经存在了40年，是与 医学实习生(成人医学肿瘤学研究员)为学术生涯做准备的主要目标 医药。肿瘤学研究培训的理由有四：(A)癌症仍然是主要原因之一 发病率和死亡率；(B)需要保持在我们的基础上已经取得的势头 对致癌、基因组学和免疫学的理解(C)有必要将#年取得的进展 实验室致力于开发新的更好的诊断、治疗和预防策略 癌症和(D)在迅速变化的卫生保健进步和经济格局中，迫切需要 制定工具和政策，以确定提供护理和措施的最有效和最有效的方式 社会上的结果。该计划的五个研究培训主题是精心制定的，以此为基础 过去培养学术带头人的成功经验。它融合了癌症生物学、护理和政策的新兴方面， 与44名资深的校外资助项目教员的研究兴趣和专业知识保持一致 成员，利用血液科/肿瘤科的杰出资源， 癌症中心(UMCCC)、密歇根大学医学院和其他单位。研究性培训 主题是：(1)肿瘤转化、异常信号和转移的分子遗传学机制； (2)肿瘤防治中的生物标志物；(3)药物发现和实验的分子靶点 癌症治疗学；(4)癌症治疗的免疫学方法；(5)卫生服务研究 注重交付、结果、改革和价值。被选中参加这个项目的学员将首先体验 对所选研究主题中的重要概念进行明确的课程设置和培训，然后花2- 在相关实验室和/或临床或健康服务研究环境中有3年的直接工作经验 指导一名培训计划的教员导师。受训人员将在以下方面培养技能：(A)确定重要的 肿瘤学研究中的问题(B)开发可检验的假设，以解决相关问题(C) 获得必要的技术专门知识，以严格测试已确定的假设；(D)严格评估 产生的数据；(E)培养必要的书面和口头沟通技能，以公布结论 提供和(F)开发和竞争同行评审的赠款。学员将拥有医学博士或医学博士学位， 完成内科住院医师培训和一年成人医学临床专科培训 肿瘤学/血液学。该计划的最终目标是使受训人员在学术肿瘤学方面做好准备。 作为研究型大学医学院的独立教员。

Abstract The Oncology Research Training Program (ORTP) has been in existence for 40 years and was developed with the primary goal of preparing physician-trainees (fellows in Adult Medical Oncology) for careers in academic medicine. The rationale for training in oncology research is four fold: (a) Cancer remains one of the leading cause of morbidity and mortality; (b) there is a need to maintain momentum that has been achieved in our fundamental understanding of carcinogenesis, genomics and immunology (c) there is a need to translate progress gained in the laboratory to the development of novel and better strategies for the diagnosis, therapies and prevention of cancer and (d) in the rapidly chaniging health care advances and economics landscape, a critical need for development of tools and policy to determine the most effective and efficient ways to deliver care and measure outcomes in the society. The five Research training themes of the Program are carefully developed to build on the past successes of training academic leaders. It melds emerging aspects of cancer biology, care and policy, is aligned with the investigative interest and expertise of 44 established, extramurally-funded program faculty members, leverages the outstanding resources of the Division of Hematology/Oncology, the Comprehensive Cancer Center (UMCCC), the medical school and other units of the University of Michigan. The research training themes are: (1) Molecular-genetic mechanisms of neoplastic transformation, aberrant signaling, and metastasis, (2) Biomarkers in cancer prevention and therapy; (3) Molecular targets of drug discovery and experimental therapuetics of cancer; (4) Immunological approaches to cancer therapy and (5) Health services research focused on delivery, outcomes, reform and value. The trainees selected for this program will first experience well-defined curriculum and training to the important concepts in the chosen research theme, and then spend 2- 3 years in the relevant laboratory and/ or clinical or health services research environment under the direct supervision of a training program faculty mentor. The trainees will develop skills in: (a) to identify important questions in oncology research (b) develop testable hypotheses that will address the pertinent questions (c) aquire the necessary technical expertise to rigorously test the hypotheses identified; (d) critically evaluate the data generated; (e) develop the necessary skills of written and oral communication to promulgate the conclusions made and (f) develop and compete of peer-reviewed grants. The trainees will have an MD or MD-PhD degree, completed residency training in Internal Medicine and a year of clinical subspecialty training in ADULT medical oncology/hematology. The ultimate goal of the program is to prepare trainees for careers in academic oncology as independent faculty members in schools of medicine at research universities.