Mechanisms of cognitive control impairment in ME/CFS and PASC-ME/CFS

ME/CFS 和 PASC-ME/CFS 认知控制障碍的机制

• 批准号: 10717201
• 负责人: H Hamdi Eryilmaz
• 金额: $ 49.09万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10717201
• 关键词: Acceleration; American; Anterior; Attention; Autonomic Dysfunction; Brain; Brain imaging; COVID-19 pandemic; COVID-19 patient; Chronic Fatigue Syndrome; Clinical Trials; Cognition; Cognitive deficits; Complement; Conflict (Psychology); Data; Diagnosis; Dorsal; Electroencephalography; Electrophysiology (science); Exertion; Exhibits; Exposure to; Fatigue; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Immunologics; Impaired cognition; Impairment; Individual; Infection; Inflammation; Long COVID; Malaise; Measures; Memory; Methods; Neurobehavioral Manifestations; Neurocognitive Deficit; Pain; Patients; Pattern; Performance; Peripheral; Pilot Projects; Post-Acute Sequelae of SARS-CoV-2 Infection; Psychoses; Qualifying; Reaction Time; Rehabilitation therapy; Reporting; Research; SARS-CoV-2 infection; Short-Term Memory; Source; Symptoms; Time; Virus Diseases; Work; biomarker identification; brain fog; burden of illness; cingulate cortex; cognitive control; comparison control; coronavirus disease; cost; cytokine; diagnostic criteria; effective intervention; experience; improved; inflammatory marker; multimodality; neuroimaging; neuromechanism; neurophysiology; neuropsychiatry; novel; pathogen; persistent symptom; predictive modeling; targeted biomarker; targeted treatment; temporal measurement; therapy development; tool

ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a symptom-based diagnosis characterized by severe debilitating fatigue, cognitive dysfunction, and widespread pain. Most cases of ME/CFS begin with a viral infection or involve multiple exposures to pathogens over time. Soon after the onset of the COVID-19 pandemic, a significant portion of patients infected with SARS-CoV-2 developed chronic symptoms that overlap greatly with those of ME/CFS. Among the post-acute sequelae of COVID-19 (PASC), “brain fog” symptoms have been widely reported including in patients with mild initiating infection. Many PASC patients meet the diagnostic criteria for ME/CFS after 6 months of ongoing symptoms (referred to herein as PASC- ME/CFS). Given the growing number of SARS-CoV-2 infections, the disease burden on individuals with ME/CFS and PASC-ME/CFS, and the challenges associated with these conditions such as rehabilitation and workforce disruptions, elucidating the mechanisms of cognitive deficits in ME/CFS and PASC-ME/CFS is of clear

摘要 肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种基于MRI的诊断， 严重的疲劳、认知功能障碍和广泛的疼痛。大多数ME/CFS病例开始时， 病毒感染或涉及随着时间的推移多次暴露于病原体。在COVID-19爆发后不久 在大流行期间，很大一部分感染SARS-CoV-2的患者出现了慢性症状， 与ME/CFS的工作有很大重叠。在COVID-19（PASC）的急性后后遗症中，“脑雾” 症状已被广泛报道，包括在轻度初始感染的患者中。许多PASC患者 在持续症状6个月后符合ME/CFS的诊断标准（本文称为PASC- ME/CFS）。鉴于SARS-CoV-2感染的数量不断增加， ME/CFS和PASC-ME/CFS，以及与这些疾病相关的挑战，如康复和 劳动力中断，阐明ME/CFS和PASC-ME/CFS中认知缺陷的机制， 明确