Administration/Program Operations, and Biostatistics Data Mgt. & Array Analyses

行政和生物统计核心将提供关键的集中赠款管理、数据 新的微阵列数据分析，以及对项目的所有统计支持。这一核心还将 用于融合研究人员，他们的实验结果和他们的想法，对研究的评价 Fforts和批判性地指导总结努力，以保持高度整合的计划成果。这个 行政和生物统计核心的具体目标是：1)向 调查员。这包括管理项目用品、归档、编写备忘录、召开会议 会议纪要和通讯，涵盖所有业务，包括出版物。根据设计，此核心将提供 具有明确的科学和行政沟通渠道的调查人员，以促进 .赚取成员，帮助确定资源的优先顺序，因为这些资源与整合和发展 计划和项目的具体目标，并促进解决任何影响团队成员的问题。2) 提供所有项目的统计分析：a)每两周与项目调查员合作 N提出假设和研究设计；b)进行和指导数据的统计分析 包括描述性汇总统计数据和复杂的推理过程，包括数组 分析；c)生物统计工作应包括及时审查、质量保证、传播结果 从所有项目的调查中收集；d)提供专门的微阵列数据分析和认证 支持这一有针对性的计划努力。在这一核心的重组下，生物统计人员将 建立和管理一个新的基于Web的数据交换中心，以实现数据共享和实时数据集成 在项目和核心之间讨论结果。3)组织项目月度会议 督导委员会。该指导委员会应由项目和核心绩效指标组成。4)组织 为项目所有成员及其实验室成员安排项目会议。5)组织内部 评审委员会会议，由专家小组评估计划的有效性和 实验进展、研究方向、技术方法、统计评估和管理 有效性。6)组织一次外部审查委员会年度会议。外部组织的成员 审查委员会应审查所有实验结果和结果，帮助确定调查的优先顺序，审查 协作的协调，并评估从研究中出现的概念。7)提供 为调查员提供与项目有关的通信的出版服务，其中包括 编写稿件、摘要和其他出版物。8}提供全面的财务审查、会计核算 和实时预算分析。这包括报告、口头交流、回顾和前瞻性 对支出的预测。

The Administrative and Biostatistics Core will provide critical centralized grant administration, data jrocessing, new microarray data analysis, and all statistical support for the projects. This Core will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research fforts and critically direct the summary efforts toward maintaining a highly integrated program outcome. The Specific Aims of the Administrative and Biostatistics Core are: 1) Provide administrative services to the nvestigators. This includes the management of project supplies, filing, development of memos, meeting minutes and communications covering all operations, including publications. By design, this core will provide nvestigators with clear lines of scientific and administrative communication to promote collaboration among .earn members, aid in the prioritization of resources as they relate to the integration and progression of the program and project specific aims, and facilitate resolution of any problems that affect team members. 2) rovide statistical analyses for all projects: A) To collaborate with project investigators on a biweekly basis n the formulation of hypotheses and study design; B) To conduct and direct the statistical analysis of data ncluding both descriptive summary statistics and sophisticated inferential procedures, including array analyses; C) Biostatistics efforts shall include timely review, quality assurance, dissemination of the results gleaned from investigations in all projects; D) Provide specialized microarray data analyses and credentialed support for this targeted program effort. Under the reorganization of this Core the Biostatistics personnel will set up and manage a new web based data clearing house for data sharing and data integration for real time discussions of results between the projects and cores. 3) Organize monthly meetings of the Program Steering Committee. This Steering committee shall consist of the Project and Core Pis. 4) Organize Program Project meetings for all members of the project and their laboratory members. 5) Organize Internal Review Committee meeting where a panel of experts shall assess the Program effectiveness and experimental progress, research directions, technical approaches, statistical evaluation, and administrative effectiveness. 6) Organize an annual External Review Committee meeting. The members of External Review Committee shall review all experimental findings and outcomes, help prioritize investigations, review the coordination of collaborations, and evaluate concepts that emerge from the studies. 7) Provide publication services to the investigators for project-related communications where this includes the preparation of manuscripts, abstracts and other publications. 8} Provide overall fiscal review, accounting and real time budgets analyses. This includes reports, verbal communications, reviews and forward-looking projections on expenditures.