Administration/Program Operations, and Biostatistics Data Mgt. & Array Analyses

行政和生物统计核心将提供关键的中央赠款管理、数据和信息。 新的微阵列数据分析，以及项目的所有统计支持。该核心还将 有助于将研究人员、他们的实验结果和他们的想法、研究的评价 坚定地、批判性地指导总结工作，以保持高度综合的项目成果。的 行政和生物统计核心的具体目标是：（1）为 调查员这包括项目供应的管理，归档，备忘录的开发，会议 包括出版物在内的所有业务的会议记录和通信。根据设计，该核心将提供 研究人员有明确的科学和行政沟通路线，以促进合作， .赚取成员，在资源的优先次序，因为它们涉及到的整合和发展的援助， 计划和项目的具体目标，并促进解决任何影响团队成员的问题。（二） 为所有项目提供统计分析：A）每两周与项目调查员合作 假设和研究设计的制定; B）进行和指导数据的统计分析 包括描述性汇总统计和复杂的推理程序，包括数组 C）生物统计工作应包括及时审查、质量保证、结果的传播 从所有项目的调查中收集; D）提供专业的微阵列数据分析和认证 支持这项有针对性的计划。根据本核心的重组，生物统计人员将 建立和管理一个新的基于网络的数据交换所，用于真实的实时数据共享和数据集成 项目和核心之间的结果讨论。3)组织方案的月度会议 指导委员会。该指导委员会应由项目和核心PI组成。4)组织 为项目的所有成员及其实验室成员安排项目会议。5)组织内部 审查委员会会议，专家小组应评估计划的有效性， 实验进展、研究方向、技术方法、统计评价和管理 有效性6)组织召开年度外部审查委员会会议。外部成员 审查委员会应审查所有实验发现和结果，帮助确定调查的优先顺序，审查 协调合作，并评估研究中出现的概念。7)提供 向调查人员提供与项目有关的通信出版服务，其中包括 编写手稿、摘要和其他出版物。8}提供全面的财务审查，会计 和真实的时间预算分析。这包括报告、口头沟通、审查和前瞻性 支出预测。

The Administrative and Biostatistics Core will provide critical centralized grant administration, data jrocessing, new microarray data analysis, and all statistical support for the projects. This Core will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research fforts and critically direct the summary efforts toward maintaining a highly integrated program outcome. The Specific Aims of the Administrative and Biostatistics Core are: 1) Provide administrative services to the nvestigators. This includes the management of project supplies, filing, development of memos, meeting minutes and communications covering all operations, including publications. By design, this core will provide nvestigators with clear lines of scientific and administrative communication to promote collaboration among .earn members, aid in the prioritization of resources as they relate to the integration and progression of the program and project specific aims, and facilitate resolution of any problems that affect team members. 2) rovide statistical analyses for all projects: A) To collaborate with project investigators on a biweekly basis n the formulation of hypotheses and study design; B) To conduct and direct the statistical analysis of data ncluding both descriptive summary statistics and sophisticated inferential procedures, including array analyses; C) Biostatistics efforts shall include timely review, quality assurance, dissemination of the results gleaned from investigations in all projects; D) Provide specialized microarray data analyses and credentialed support for this targeted program effort. Under the reorganization of this Core the Biostatistics personnel will set up and manage a new web based data clearing house for data sharing and data integration for real time discussions of results between the projects and cores. 3) Organize monthly meetings of the Program Steering Committee. This Steering committee shall consist of the Project and Core Pis. 4) Organize Program Project meetings for all members of the project and their laboratory members. 5) Organize Internal Review Committee meeting where a panel of experts shall assess the Program effectiveness and experimental progress, research directions, technical approaches, statistical evaluation, and administrative effectiveness. 6) Organize an annual External Review Committee meeting. The members of External Review Committee shall review all experimental findings and outcomes, help prioritize investigations, review the coordination of collaborations, and evaluate concepts that emerge from the studies. 7) Provide publication services to the investigators for project-related communications where this includes the preparation of manuscripts, abstracts and other publications. 8} Provide overall fiscal review, accounting and real time budgets analyses. This includes reports, verbal communications, reviews and forward-looking projections on expenditures.