Molecular mechanisms driving therapy-induced lineage plasticity

驱动治疗诱导的谱系可塑性的分子机制

• 批准号: 10730635
• 负责人: Juan Francisco Linares Rodriguez
• 金额: $ 16.07万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730635
• 关键词: Area; Automobile Driving; Award; Bioinformatics; Cancer Biology; Cell Reprogramming; Dedications; Developmental Process; Epigenetic Process; Funding; Grant; Inflammation; Knowledge; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Medicine; Mesenchymal; Metabolism; Molecular; Molecular Biology; Neurosecretory Systems; Pathology; Process; Prostatic Neoplasms; Research; Resistance; Scientist; Seminal; Signal Transduction; Solid; Specialist; Technical Expertise; Therapeutic; Time; Training; Variant; Wages; bioinformatics tool; cancer cell; cancer cell differentiation; castration resistant prostate cancer; design; effective therapy; human disease; in vivo; mouse model; novel; pressure; programs; prostate cancer cell; success; tumor metabolism

SUMMARY This proposal seeks Dr. Juan Francisco Linares’s salary as a Research Specialist to support Dr. Maria T. Diaz-Meco’s research program at the Weill Cornell Medicine Department of Pathology and Laboratory Medicine to study the molecular and cellular mechanisms that regulate lineage plasticity in prostate cancer. The elucidation of the molecular mechanisms that castration-resistant prostate cancer cells (CRPC) use to evade therapeutic pressures requires scientists with an in-depth understanding of the molecular biology of this process, but also with the required technical expertise in in vivo mouse models that faithfully recapitulate human disease, as well as the necessary bioinformatics tools to perform rigorously epigenetic analysis. Therefore, with this Research Specialist Award, we intend to provide stable research opportunities for the exceptional scientist Juan Francisco Linares to develop impactful research in this area of expertise. He has made seminal contributions in signaling, inflammation, metabolism, and cancer and has solid interdisciplinary training that will be critical for the project’s success. He will contribute to the research program focused on defining the molecular and cellular mechanisms that drive the differentiation of CRPC to more aggressive prostate cancer variants, such as Neuroendocrine and Mesenchymal prostate cancer. With his expertise in cancer biology and cancer metabolism and his capacity to apply novel mouse models and bioinformatics approaches, he is filling a unique niche within the Diaz-Meco lab that will provide continuity, stability, and detailed scientific knowledge to achieve the aims of the NCI-funded grants. Dr. Linares’s long-time expertise and dedication will advance our understanding of the lineage plasticity in CRPC to help design more effective therapies to overcome the acquired resistance in prostate cancer.

概括 该提案要求 Juan Francisco Linares 博士作为研究专家支付工资，以支持 Maria T. 迪亚兹-梅科在威尔康奈尔医学病理学和实验医学系的研究项目 研究调节前列腺癌谱系可塑性的分子和细胞机制。这 阐明去势抵抗性前列腺癌细胞（CRPC）逃避的分子机制 治疗压力需要科学家深入了解这一过程的分子生物学， 而且还拥有忠实再现人类疾病的体内小鼠模型所需的技术专业知识， 以及进行严格的表观遗传分析所需的生物信息学工具。因此，有了这个 研究专家奖，我们打算为杰出的科学家胡安提供稳定的研究机会 Francisco Linares 将在这一专业领域开展有影响力的研究。他在以下领域做出了开创性贡献 信号、炎症、代谢和癌症，并拥有扎实的跨学科培训，这对于 项目的成功。他将为专注于定义分子和细胞的研究项目做出贡献 驱动 CRPC 分化为更具侵袭性的前列腺癌变体的机制，例如 神经内分泌和间充质前列腺癌。凭借他在癌症生物学和癌症代谢方面的专业知识 以及他应用新型小鼠模型和生物信息学方法的能力，他正在填补一个独特的空白 Diaz-Meco 实验室将提供连续性、稳定性和详细的科学知识，以实现以下目标： NCI 资助的赠款。 Linares 博士长期的专业知识和奉献精神将增进我们对 CRPC 中的谱系可塑性有助于设计更有效的疗法来克服 CRPC 中的获得性耐药性 前列腺癌。