Core 2: BSL-3 Practices Core

核心 2：BSL-3 实践核心

• 批准号: 10791949
• 负责人: Scott Alderman
• 金额: $ 92.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10791949
• 关键词: 2019-nCoV; Alphavirus; Animal Model; Applied Research; Area; Basic Science; Biological; Biological Assay; Cellular Assay; Certification; Containment; Coronavirus; Cytomegalovirus; Dangerousness; Dedications; Diagnostic; Ebola; Education; Ensure; Environment; Equipment and supply inventories; Fee-for-Service Plans; Ferrets; Flavivirus; Funding; Grant; HIV; Hamsters; Heart; Hemagglutination; Home; Human; Human Resources; Immune response; Immunology; In Vitro; Individual; Infection; Influenza; Laboratories; Location; Malaria; Microbiology; Mission; Molecular; Mus; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Oryctolagus cuniculus; Performance; Pharmaceutical Preparations; Poxviridae; Procedures; Proteins; Protocols documentation; Publications; Readiness; Research; Research Design; Research Personnel; Research Support; Resource Development; Route; Safety; Secure; Security; Serology; Services; Site; Societies; Therapeutic; Time; Training; Training Activity; Training Programs; Training Support; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vaccines; Viral Load result; Virus; Work; Workforce Development; Yersinia pestis; ZIKA; animal imaging; biodefense; biosecurity; design; emerging pathogen; experience; future pandemic; global health; hands on instruction; immune reconstitution; improved; in vivo; influenzavirus; instrumentation; lens; member; multiplex assay; novel vaccines; operation; pathogen; programs; square foot; supportive environment; theories; virology

ABSTRACT – BSL-3 Practices Core (Core 2) The central mission of the Regional Biocontainment Laboratory Network is to provide a location and an environment in which groundbreaking research on potentially dangerous pathogens can be performed safely. As anyone with the responsibility of managing a leading BSL-3/ABSL-3 facility such as the Duke RBL will attest, it is critical to imbue a culture of safety in which all individuals seek continuous improvement and refinement of best practices. This culture of constant improvement must be sustained through the inevitable turnover of staff that occurs in any long-standing facility, and while it is difficult to codify, we pride ourselves on providing a cordial and supportive environment in which ideas for improvement by all members of the team are welcomed. Viewed through this lens, the practices and Standard Operating Procedures (SOPs) that define the Duke RBL are continuously being refined and improved. Since the opening of the facility in 2007, the Duke RBL has led the field with a world class safety team dedicated to providing safe, secure, and compliant research through managing SOPs, conducting a rigorous training program, and assessments of performance. Support from this grant will allow for the further enhancement of these programs through warm-readiness and additional dedicated safety staff. Specific aims for this proposal are to 1) establish and maintain procedures for safe and compliant research at BSL-3/ABSL-3; 2) provide biosafety theory education with hands-on instruction for all personnel entering BSL-3/ABSL-3 for work with Select Agents; and 3) ensure continuous compliance with established procedures by conducting routing biosafety/security audits and drills. The ability to maintain and expand these robust safety programs to account for novel pathogens is critical for investigators to adequately prepare for the next pandemic.

摘要- BSL-3实践核心（核心2） 区域生物防护实验室网络的中心使命是提供一个地点和一个 在这样的环境中，可以安全地对潜在危险的病原体进行开创性的研究。 正如任何负责管理领先的BSL-3/ABSL-3设施（如杜克RBL）的人一样， 证明，至关重要的是要灌输一种安全文化，在这种文化中，所有人都寻求不断改进， 完善最佳做法。这种不断改进的文化必须通过不可避免的 在任何长期存在的设施中发生的工作人员更替，虽然很难编纂，但我们感到自豪的是， 提供一个亲切和支持性的环境，让团队所有成员都能提出改进的想法， 欢迎光临。从这个透镜来看， 杜克RBL正在不断完善和改进。自2007年该设施开放以来，杜克 RBL拥有世界一流的安全团队，致力于提供安全、可靠、合规的产品， 通过管理SOP进行研究，进行严格的培训计划和绩效评估。 这笔赠款的支持将使这些方案得到进一步加强， 增加专职安全人员。本提案的具体目标是：（1）建立和维持以下程序： 在BSL-3/ABSL-3进行安全和合规研究; 2）提供生物安全理论教育和实践指导 所有进入BSL-3/ABSL-3与特定代理人一起工作的人员;以及3）确保持续合规 通过进行路由生物安全/安保审计和演习，按照既定程序进行。能力保持 并扩大这些强大的安全计划，以解释新的病原体是至关重要的研究人员， 为下一次大流行做好充分准备。