CRH dysregulation of brainstem autonomic circuits increases SUDEP risk

脑干自主回路的 CRH 失调会增加 SUDEP 风险

• 批准号: 10786432
• 负责人: Jamie Lynn Maguire
• 金额: $ 4.35万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10786432
• 关键词: Autonomic nervous system; Behavior assessment; Behavioral; Brain Stem; CRH gene; Career Choice; Chronic; Chronic stress; Collaborations; Doctor of Philosophy; Electrophysiology (science); Epilepsy; Frequencies; Goals; Journals; Knowledge; Letters; Methods; Modeling; Neurosciences; Operative Surgical Procedures; Outcome; Parents; Postbaccalaureate; Recurrence; Regulation; Research; Research Training; Risk; Science; Seizures; Stress; System; Technical Expertise; Techniques; Training; United States National Institutes of Health; Visit; career; career development; early life stress; experience; in vivo; innovation; interest; kainate; meetings; nervous system disorder; parent grant; programs; psychiatric comorbidity; research and development; sudden unexpected death in epilepsy; training opportunity

PROJECT SUMMARY This Diversity Supplement will support Emanuel Coleman to further his technical and career development training to prepare to apply for a Ph.D. program in Neuroscience. Building on his previous research experience investigating the behavioral sequelae of early life stress and his interest in neurological disorders, he will conduct research related, but not overlapping with the parent grant which seeks to investigate the impact of chronic stress on epilepsy outcomes. Manny’s project will investigate the impact of early life stress on epilepsy outcomes, strengthening the overall goals of the parent application while providing Manny with an independent research experience and career development training. This project will also examine whether early life stress alters the frequency of spontaneous recurrent seizures in the intrahippocampal kainate model of chronic epilepsy. He will evaluate whether early life stress increases vulnerability to psychiatric comorbities in epilepsy and/or SUDEP risk. He will gain training in in vivo electrophysiological methods, surgical techniques, and behavioral assessments. In addition, he will participate in lab meetings, journal clubs, Departmental seminars, and participate in career development training alongside the Building Diversity in Biomedical Sciences program. In addition, the parent grant involves a collaboration with Dr. Carie Boychuk’s lab at UTHSA. Under this Diversity Supplement, Manny will have the opportunity to visit Dr. Boychuk’s lab and gain knowledge regarding the regulation of the autonomic nervous system and the impact of stress on this system (see letter attached). This is a technically feasible and conceptually innovative project which will expand Manny’s technical skills and prepare him for the next steps in his graduate career.

项目总结 这份多样性副刊将支持伊曼纽尔·科尔曼进一步发展他的技术和职业生涯 为申请神经科学博士学位做准备的培训。以他以前的研究经验为基础 调查早期生活压力的行为后遗症，以及他对神经障碍的兴趣，他将进行 相关研究，但不与家长资助重叠，旨在调查慢性压力的影响 关于癫痫的结果。曼尼的项目将调查早期生活压力对癫痫结果的影响， 加强家长应用程序的总体目标，同时为曼尼提供独立研究 经验和职业发展培训。该项目还将研究早期生活压力是否会改变 慢性癫痫海马内海人酸模型中自发性反复发作的频率。他会的 评估早期生活应激是否增加癫痫和/或SUDEP患者精神合并症的易感性 风险。他将接受体内电生理方法、外科技术和行为学方面的培训 评估。此外，他还将参加实验室会议、期刊俱乐部、部门研讨会和 与生物医学科学多样性建设计划一起参加职业发展培训。在……里面 此外，家长资助还包括与加州大学洛杉矶分校的Carie Boychuk博士的实验室合作。在这种多样性之下 作为补充，曼尼将有机会参观博伊丘克博士的实验室，并了解有关 自主神经系统的调节以及压力对该系统的影响(见所附信函)。这 是一个技术上可行和概念上创新的项目，它将扩大曼尼的技术技能和 为他的研究生生涯的下一步做好准备。