CRH dysregulation of brainstem autonomic circuits increases SUDEP risk

脑干自主回路的 CRH 失调会增加 SUDEP 风险

• 批准号: 10786432
• 负责人: Jamie Lynn Maguire
• 金额: $ 4.35万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10786432
• 关键词: Autonomic nervous system; Behavior assessment; Behavioral; Brain Stem; CRH gene; Career Choice; Chronic; Chronic stress; Collaborations; Doctor of Philosophy; Electrophysiology (science); Epilepsy; Frequencies; Goals; Journals; Knowledge; Letters; Methods; Modeling; Neurosciences; Operative Surgical Procedures; Outcome; Parents; Postbaccalaureate; Recurrence; Regulation; Research; Research Training; Risk; Science; Seizures; Stress; System; Technical Expertise; Techniques; Training; United States National Institutes of Health; Visit; career; career development; early life stress; experience; in vivo; innovation; interest; kainate; meetings; nervous system disorder; parent grant; programs; psychiatric comorbidity; research and development; sudden unexpected death in epilepsy; training opportunity

PROJECT SUMMARY This Diversity Supplement will support Emanuel Coleman to further his technical and career development training to prepare to apply for a Ph.D. program in Neuroscience. Building on his previous research experience investigating the behavioral sequelae of early life stress and his interest in neurological disorders, he will conduct research related, but not overlapping with the parent grant which seeks to investigate the impact of chronic stress on epilepsy outcomes. Manny’s project will investigate the impact of early life stress on epilepsy outcomes, strengthening the overall goals of the parent application while providing Manny with an independent research experience and career development training. This project will also examine whether early life stress alters the frequency of spontaneous recurrent seizures in the intrahippocampal kainate model of chronic epilepsy. He will evaluate whether early life stress increases vulnerability to psychiatric comorbities in epilepsy and/or SUDEP risk. He will gain training in in vivo electrophysiological methods, surgical techniques, and behavioral assessments. In addition, he will participate in lab meetings, journal clubs, Departmental seminars, and participate in career development training alongside the Building Diversity in Biomedical Sciences program. In addition, the parent grant involves a collaboration with Dr. Carie Boychuk’s lab at UTHSA. Under this Diversity Supplement, Manny will have the opportunity to visit Dr. Boychuk’s lab and gain knowledge regarding the regulation of the autonomic nervous system and the impact of stress on this system (see letter attached). This is a technically feasible and conceptually innovative project which will expand Manny’s technical skills and prepare him for the next steps in his graduate career.

项目概要 该多样性补充品将支持伊曼纽尔·科尔曼进一步发展他的技术和职业发展 准备申请博士学位的培训神经科学计划。基于他之前的研究经验 研究早期生活压力的行为后遗症以及他对神经系统疾病的兴趣，他将进行 研究相关，但与旨在调查慢性压力影响的家长资助不重叠 关于癫痫的结果。曼尼的项目将调查早期生活压力对癫痫结果的影响， 加强家长申请的总体目标，同时为曼尼提供独立研究 经验和职业发展培训。该项目还将研究早期生活压力是否会改变 慢性癫痫海马内红藻氨酸模型中自发性复发性癫痫发作的频率。他会 评估早期生活压力是否会增加癫痫和/或 SUDEP 精神并发症的易感性 风险。他将接受体内电生理方法、手术技术和行为方面的培训 评估。此外，他还将参加实验室会议、期刊俱乐部、部门研讨会和 参加职业发展培训以及生物医学科学项目的多样性建设。在 此外，家长资助还涉及与 UTHSA Carie Boychuk 博士实验室的合作。在这种多样性下 补充一下，Manny将有机会参观Boychuk博士的实验室并获得有关 自主神经系统的调节以及压力对该系统的影响（见所附信件）。这 是一个技术上可行且概念上创新的项目，它将扩展曼尼的技术技能和 为他研究生生涯的下一步做好准备。