CEIRR: SARS-CoV-2 Research Activities

CEIRR：SARS-CoV-2 研究活动

• 批准号: 10788195
• 负责人: RICHARD WEBBY
• 金额: $ 169.18万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10788195
• 关键词: 2019-nCoV; Animals; Basic Science; Cohort Studies; Coronavirus; Disease Outcome; Environmental Risk Factor; Evolution; Human; Immune; Immune response; Immunologic Factors; Infection; Molecular; Pathogenicity; Research Activity; Sampling; Vaccination; Virus; cross immunity; improved; respiratory virus; response; transmission process

CEIRR will determine the molecular, ecologic and/or environmental factors that influence the evolution, emergence, transmission and pathogenicity of respiratory viruses, including coronaviruses such as SARS-CoV-2, and characterize the immune response to infection to improve understanding of the immune correlates of protection and cross-protection. CEIRR will carry out a host of activities, including cohort studies and human and animal sampling to further understanding of infection, transmission and vaccination; identification of immunological factors that determine disease outcome in the response to infection and vaccination; and studies to determine how viruses evolve, adapt and transmit between humans and at interspecies interfaces.

CEIRR将确定影响呼吸道病毒（包括SARS-CoV-2等冠状病毒）进化、出现、传播和致病性的分子、生态和/或环境因素，并表征对感染的免疫反应，以提高对保护和交叉保护的免疫相关性的理解。CEIRR将开展一系列活动，包括队列研究和人类和动物采样，以进一步了解感染、传播和疫苗接种;确定在对感染和疫苗接种的反应中决定疾病结果的免疫因素;以及研究确定病毒如何演变、适应和在人类之间和物种间界面传播。