MESA TASK AREA A - CORE STUDY OPERATIONS FIELD CENTER (FC).

动脉粥样硬化的多种族研究（梅萨）是一项关于动脉粥样硬化的相关因素、预测因素和进展的研究。 亚临床心血管疾病（CVD）在45-84岁男性和女性的不同人群样本中 在基线时没有临床CVD的证据。在梅萨的初始供资期间，6 814名参与者 在2000-2002年期间，从六个现场中心招募了100名患者，并检查了亚临床冠状动脉病变的证据。 动脉粥样硬化，使用计算机断层扫描，心脏MRI，颈动脉超声，血流介导的肱动脉 扩张、桡动脉张力测定、踝肱指数测量和视网膜照相。一些 其他变量包括腹主动脉CT、颈动脉MRI、心脏MRI标记，用于测量区域 心肌功能;确定和推定的实验室风险标志物;社会经济学，心理学， 行为和环境特征;并在梅萨的子集中评估遗传变异 队列。在随后的五次检查中重复检查选定的组件， 自2010年以来，该队列已持续随访临床CVD事件约16年。 基线检查。 本提案是针对NHLBI RFP（编号75 N92018 R 0078，多种族研究， 运动训练中心），旨在继续对梅萨参与者进行跟踪和检查 努力实现以下科学目标：1）提高统计能力， 临床结果的预测因素，特别是在信息亚组中; 2）研究亚临床至 临床CVD;和3）确定新的风险因素或告知疾病的因素之间的相互作用 病理生理学此外，还将实现以下操作目标：1）继续队列随访 和信息收集，以记录临床事件; 2）继续促进科学合作; 3） 对梅萨参与者进行有限的临床检查，作为辅助研究检查的平台 件. 该研究将继续支持在NHLBI合同之外资助的深入辅助研究。 这些研究将在操作上集成到主研究中，数据将在整个研究中共享。 “梅萨套件”研究，根据当前梅萨和NIH数据共享政策。研究数据将提供给 通过定义的流程，鼓励最大限度地利用数据，同时保护 参与者保密。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92018R0078, Multi-Ethnic Study of Atherosclerosis – Field Center) that seeks to continue the follow-up and examination of the MESA participants in an effort to address the following scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. In addition, the following operational goals will be addressed: 1) continue cohort follow-up and information collection to document clinical events; 2) continue to foster scientific collaborations; and 3) conduct a limited clinical examination of the MESA participants as a platform for ancillary study examination components. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.