Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

动脉粥样硬化多种族研究 (MESA) 是一项针对相关因素、预测因素和风险因素的研究 不同人群男性样本中亚临床心血管疾病 (CVD) 的进展 以及基线时没有临床心血管疾病证据的 45-84 岁女性。在初始融资期间 MESA 期间，2000-2002 年从六个现场中心招募了 6,814 名参与者 使用计算机断层扫描、心脏检查检查亚临床冠状动脉粥样硬化的证据 MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉张力测定、踝肱 折射率测量和视网膜摄影。许多其他变量，包括腹主动脉 CT、颈动脉 MRI、心脏 MRI 标记，用于测量局部心肌功能；成立并 假定的实验室风险标记；社会经济、心理、行为和环境 特点；并在 MESA 队列的子集中评估遗传变异。考试 选定的组件在随后的五次检查中重复进行，涵盖约 16 年，自基线以来一直对队列进行临床心血管事件跟踪 考试。 该研究将继续支持 NHLBI 之外资助的深入辅助研究 合同。这些研究将在操作上整合到主要研究中，并且数据将被共享 根据当前的 MESA 和 NIH 数据共享政策，涵盖整个“MESA 套件”研究。的 研究数据将通过明确的流程提供给感兴趣的研究人员，该流程鼓励 最大限度地利用数据，同时保护参与者的机密性。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.