BSL-3 Practices Core

BSL-3 实践核心

• 批准号: 10793954
• 负责人: Ying Kong
• 金额: $ 33.6万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793954
• 关键词: Accountability; Animals; Area; Aromatase; Biochemistry; Certification; Collaborations; Communication; Competence; Containment; Dedications; Development; Emerging Communicable Diseases; Engineering; Ensure; Equipment; Equipment and supply inventories; Faculty; Focus Groups; Funding; Goals; Growth; Health Sciences; Human Resources; Immunology; Individual; Institution; Investments; Laboratories; Laboratory Study; Medicine; Microbiology; Mission; Persons; Pharmacy facility; Productivity; Protocols documentation; Research; Research Personnel; Research Support; Safety; Secure; Security; Services; Site Visit; Specialist; Tennessee; Training; United States National Institutes of Health; Universities; Viral; Wages; Work; biodefense; biosecurity; college; instrumentation; laboratory facility; member; operation; pandemic disease; pandemic preparedness; pandemic response; pathogen; professional atmosphere; programs; promote resilience; research facility; working group

PROJECT ABSTRACT The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) mission is to maintain a facility for research that requires biosafety level-3 (BSL-3) or animal (ABSL-3) containment. The UTHSC RBL has the appropriate management team, staff, engineering controls, equipment, and facilities to support bacterial, viral, and fungal research programs necessitating BSL-2, BSL-3, ABSL-2 and ABSL-3 containment; however, the mission of the RBL is to facilitate BSL-3 and ABSL-3 research. As an NIH funded facility, the priority for use of the facility is for those with NIH funding requiring BSL-3 or ABSL-3 containment. Hence, the BSL-3 Practices Core is a cornerstone of all facility management, operations and research-related activities that take place in the UTHSC RBL. The rationale for having a BSL-3 Practices Core is (1) that it will integrate the management of operations and training for BSL-3 pathogens of which some are select agents, (2) promotes communication between Research Safety Affairs, UTREC (UTHSC Regional Biocontainment Laboratory Executive Committee) and the RBL Managers, and (3) harmonize compliance, security, individual competency, and practices across our RBL Staff and our users. Hence this will increase efficiency of services provided for the BSL-3 practices. The major aims and goals for the BSL-3 Practices Core in this UC7 application are as follows. This core is significant as biosafety, biosecurity, and BSL-3 practices for BSL-3 research is integrated into every aspect of the UTHSC RBL and is critical and essential for its function. The objectives of the BSL-3 Practices Core are to: Objective 1. To enhance the efficiency of the UTHSC RBL in its support of research programs and enhance the research productivity of the investigators who may use the RBL; Objective 2. Management and operation of the RBL BSL-3 Practices Core; and Objective 3. To ensure a safe and secure work environment within the RBL through training, provision of SOPs, support in development of SOPs, select agent inventory and accountability.

项目摘要 田纳西大学健康科学中心(UTHSC)区域生物遏制实验室(RBL) 任务是维护一个需要生物安全级别3(BSL-3)或动物安全级别(ABSL-3)的研究设施 遏制。UTHSC RBL拥有适当的管理团队、员工、工程控制、设备、 以及支持细菌、病毒和真菌研究项目的设施，这些项目需要BSL-2、BSL-3、ABSL-2和 ABSL-3遏制；然而，RBL的任务是促进BSL-3和ABSL-3的研究。作为一名美国国立卫生研究院 资助的设施，优先使用该设施是那些有NIH资金需要BSL-3或ABSL-3的人 遏制。因此，BSL-3实践核心是所有设施管理、运营和 在UTHSC RBL开展的与研究相关的活动。 拥有BSL-3实践核心的理由是：(1)它将整合运营管理 和对BSL-3病原体的培训，其中一些是选定的病原体，(2)促进 研究安全事务、UTREC(UTHSC区域生物遏制实验室执行委员会)和 RBL经理，以及(3)协调我们整个RBL的合规性、安全性、个人能力和实践 员工和我们的用户。因此，这将提高为BSL-3实践提供的服务的效率。少校 本UC7应用程序中BSL-3实践核心的目的和目标如下。这一核心意义重大，因为 BSL-3研究的生物安全、生物安保和BSL-3实践被整合到 UTHSC RBL，对其功能至关重要。 BSL-3实践核心的目标是：目标1.提高UTHSC的效率 RBL支持研究计划，并提高研究人员的研究效率，这些研究人员可以 使用成果文件；目标2.成果文件BSL-3实践核心的管理和运作；以及目标3。 通过培训、提供SOP、在以下方面提供支持，确保RBL内的工作环境安全可靠 制定标准操作规程，选择代理商的库存和责任。