BSL-3 Practices Core

项目摘要 田纳西大学健康科学中心（UTHSC）区域生物防护实验室（RBL） 使命是维护一个研究设施，需要生物安全等级-3（BSL-3）或动物（ABSL-3） 安全壳UTHSC RBL拥有适当的管理团队、员工、工程控制、设备， 和设施，以支持细菌，病毒和真菌的研究计划，需要BSL-2，BSL-3，ABSL-2和 ABSL-3遏制;然而，RBL的使命是促进BSL-3和ABSL-3的研究。作为NIH 资助的设施，优先使用该设施是为那些与NIH资助需要BSL-3或ABSL-3 安全壳因此，BSL-3实践核心是所有设施管理、运营和 研究相关的活动发生在UTHSC RBL。 BSL-3实践核心的基本原理是：（1）它将整合运营管理 和BSL-3病原体的培训，其中一些是选择代理，（2）促进沟通， 研究安全事务部、UTREC（UTHSC区域生物防护实验室执行委员会）和 RBL经理，以及（3）在我们的RBL中协调合规性、安全性、个人能力和实践 我们的员工和用户因此，这将提高为BSL-3业务提供服务的效率。主要 UC 7应用程序中BSL-3实践核心的目的和目标如下。这一核心意义重大， 生物安全，生物安保和BSL-3研究的BSL-3实践被整合到每个方面， UTHSC RBL是其功能的关键和必要条件。 BSL-3实践核心的目标是：目标1。提高UTHSC的效率 RBL支持研究项目，提高研究人员的研究生产力， 使用RBL;目标2. RBL BSL-3实践核心的管理和运作;以及目标3。到 通过培训、提供标准操作程序、支持 制定标准操作规程，选择代理商库存和问责制。

PROJECT ABSTRACT The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) mission is to maintain a facility for research that requires biosafety level-3 (BSL-3) or animal (ABSL-3) containment. The UTHSC RBL has the appropriate management team, staff, engineering controls, equipment, and facilities to support bacterial, viral, and fungal research programs necessitating BSL-2, BSL-3, ABSL-2 and ABSL-3 containment; however, the mission of the RBL is to facilitate BSL-3 and ABSL-3 research. As an NIH funded facility, the priority for use of the facility is for those with NIH funding requiring BSL-3 or ABSL-3 containment. Hence, the BSL-3 Practices Core is a cornerstone of all facility management, operations and research-related activities that take place in the UTHSC RBL. The rationale for having a BSL-3 Practices Core is (1) that it will integrate the management of operations and training for BSL-3 pathogens of which some are select agents, (2) promotes communication between Research Safety Affairs, UTREC (UTHSC Regional Biocontainment Laboratory Executive Committee) and the RBL Managers, and (3) harmonize compliance, security, individual competency, and practices across our RBL Staff and our users. Hence this will increase efficiency of services provided for the BSL-3 practices. The major aims and goals for the BSL-3 Practices Core in this UC7 application are as follows. This core is significant as biosafety, biosecurity, and BSL-3 practices for BSL-3 research is integrated into every aspect of the UTHSC RBL and is critical and essential for its function. The objectives of the BSL-3 Practices Core are to: Objective 1. To enhance the efficiency of the UTHSC RBL in its support of research programs and enhance the research productivity of the investigators who may use the RBL; Objective 2. Management and operation of the RBL BSL-3 Practices Core; and Objective 3. To ensure a safe and secure work environment within the RBL through training, provision of SOPs, support in development of SOPs, select agent inventory and accountability.