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Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition

Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition
补充：重组 microRNA 在异生物质代谢和处置中的作用
批准号：
10796456
负责人：
Aiming Yu
金额：
$6.0万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-06-01 至 2026-03-31
来源：
https://reporter.nih.gov/project-details/10796456
关键词：
Administrative SupplementAwardBiologicalBiomedical EngineeringComplexCoupledDedicationsElementsExposure toFermentationGoalsHigh Pressure Liquid ChromatographyIndividualLiquid substanceMeasurementMeasuresMetabolismMicroRNAsPharmaceutical PreparationsPolynucleotidesPost-Transcriptional RegulationProductionPumpQuality ControlRNARecombinantsReproducibilityResearchRoleSamplingSystemTechnologyTissuesXenobiotic MetabolismXenobioticsdetectordrug dispositiondrug metabolismin vivomicrobialnovelpressure

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中文摘要
翻译
项目摘要 本行政补充正在进行的R35 GM 140835裁决是寻求购买一种新的液体 色谱（LC）系统，将用于确定新的重组microRNA的纯度 通过体内发酵生产产生的生物RNA，并准确定量靶标 复杂生物样品中的异生物质/药物和代谢物。这些研究是 MIRA奖，这将建立的作用和重要性，微RNA的转录后调控， 异生物质代谢和处置。
英文摘要
PROJECT SUMMARY This Administrative Supplement to ongoing R35GM140835 award is to seek for purchasing a new liquid chromatograph (LC) system that will be used to determine the purity of novel recombinant microRNAs (BioRNAs) generated through in vivo fermentation production and accurately quantitate target xenobiotic/drugs and metabolites in complex biological samples. These studies are critical elements in the MIRA award which will establish the role and importance of microRNAs in posttranscriptional regulation of xenobiotic metabolism and disposition.
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