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Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition

Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition
补充：重组 microRNA 在异生物质代谢和处置中的作用
批准号：
10796456
负责人：
Aiming Yu
金额：
$6.0万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-06-01 至 2026-03-31
来源：
https://reporter.nih.gov/project-details/10796456
关键词：
Administrative SupplementAwardBiologicalBiomedical EngineeringComplexCoupledDedicationsElementsExposure toFermentationGoalsHigh Pressure Liquid ChromatographyIndividualLiquid substanceMeasurementMeasuresMetabolismMicroRNAsPharmaceutical PreparationsPolynucleotidesPost-Transcriptional RegulationProductionPumpQuality ControlRNARecombinantsReproducibilityResearchRoleSamplingSystemTechnologyTissuesXenobiotic MetabolismXenobioticsdetectordrug dispositiondrug metabolismin vivomicrobialnovelpressure

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中文摘要
翻译
项目总结 正在进行的R35GM140835裁决的行政补充是为了寻求购买新的液体 将用于确定新型重组microRNA纯度的色谱仪(LC)系统 (BioRNAs)通过体内发酵生产并准确定量靶标 异源生物/药物和复杂生物样品中的代谢物。这些研究是 Mira奖将确立microRNAs在转录后调控中的作用和重要性 异源生物的代谢和处置。
英文摘要
PROJECT SUMMARY This Administrative Supplement to ongoing R35GM140835 award is to seek for purchasing a new liquid chromatograph (LC) system that will be used to determine the purity of novel recombinant microRNAs (BioRNAs) generated through in vivo fermentation production and accurately quantitate target xenobiotic/drugs and metabolites in complex biological samples. These studies are critical elements in the MIRA award which will establish the role and importance of microRNAs in posttranscriptional regulation of xenobiotic metabolism and disposition.
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Recombinant microRNAs in xenobiotic metabolism and disposition
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