Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition

补充：重组 microRNA 在异生物质代谢和处置中的作用

• 批准号: 10796456
• 负责人: Aiming Yu
• 金额: $ 6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796456
• 关键词: Administrative Supplement; Award; Biological; Biomedical Engineering; Complex; Coupled; Dedications; Elements; Exposure to; Fermentation; Goals; High Pressure Liquid Chromatography; Individual; Liquid substance; Measurement; Measures; Metabolism; MicroRNAs; Pharmaceutical Preparations; Polynucleotides; Post-Transcriptional Regulation; Production; Pump; Quality Control; RNA; Recombinants; Reproducibility; Research; Role; Sampling; System; Technology; Tissues; Xenobiotic Metabolism; Xenobiotics; detector; drug disposition; drug metabolism; in vivo; microbial; novel; pressure

PROJECT SUMMARY This Administrative Supplement to ongoing R35GM140835 award is to seek for purchasing a new liquid chromatograph (LC) system that will be used to determine the purity of novel recombinant microRNAs (BioRNAs) generated through in vivo fermentation production and accurately quantitate target xenobiotic/drugs and metabolites in complex biological samples. These studies are critical elements in the MIRA award which will establish the role and importance of microRNAs in posttranscriptional regulation of xenobiotic metabolism and disposition.

项目概要 本行政补充是对正在进行的 R35GM140835 奖项的行政补充，旨在寻求购买一种新的液体 将用于测定新型重组 microRNA 纯度的色谱 (LC) 系统 通过体内发酵产生的（BioRNA）并准确定量目标 复杂生物样品中的异生物质/药物和代谢物。这些研究是关键要素 MIRA 奖将确立 microRNA 在转录后调控中的作用和重要性 外源物质的代谢和处置。