Approaches to Curtail Endometrial Cancer Incidence and Mortality

减少子宫内膜癌发病率和死亡率的方法

• 批准号: 10796487
• 负责人: Michele L. Cote
• 金额: $ 2.7万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10796487
• 关键词: Address; African American population; American Association of Cancer Research; American Cancer Society; Applications Grants; Area; Awareness; Biology; Cancer Control; Cancer Survivor; Cessation of life; Classification; Collaborations; Continuance of life; Country; Coupled; Data; Development; Diagnosis; Disease; Disparity; Distress; Early Diagnosis; Endometrial Carcinoma; Epidemiology; Etiology; Future; Genetic; Goals; Gynecologic Oncology; Hereditary Malignant Neoplasm; Hereditary Neoplastic Syndromes; Heterogeneity; High Risk Woman; Histologic; Incidence; Intake; Intervention; Knowledge; Lead; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Manuscripts; Methods; Michigan; Modeling; Molecular; Molecular Analysis; Molecular Biology; Molecular Epidemiology; Monitor; Morbidity - disease rate; Not Hispanic or Latino; Omega-3 Fatty Acids; Oncology; Outcome; Pap smear; Paper; Pathology; Population Heterogeneity; Prevention; Prognosis; Publishing; Quality of life; Research; Research Personnel; Risk Reduction; Seminal; Stage at Diagnosis; Survival Rate; The Cancer Genome Atlas; Time; Uterine Cancer; Uterine hemorrhage; Uterus; Woman; Work; anticancer research; black women; cancer risk; clinical practice; cohort; dietary; early detection biomarkers; genetic association; improved; insight; meetings; metabolomics; microbiome; mortality; multidisciplinary; novel; novel marker; patient population; racial disparity; risk prediction; survivorship; symposium; tumor; tumor DNA

ABSTRACT Endometrial cancer incidence rates continue to rise, and it is the most common gynecologic cancer among women in the US. Distressingly, unlike most other cancers, the survival rates have been stagnant over the last several decades. There is a significant racial disparity in survival, with non-Hispanic black women having the poorest outcomes regardless of stage at diagnosis or histologic subtype. The reasons for this disparity, as well as other gaps in knowledge, such as approaches to monitor high risk women, or understanding survivorship issues, stand in the way of reducing the burden of endometrial cancer. This symposium will bring together experts from the fields of epidemiology, biology, pathology, oncology, genetics, and clinical practice to exchange knowledge and ideas. The discussions generated at and from this symposium will guide research to reduce incidence, morbidity and mortality from this disease. We plan a two-day symposium to be held in Detroit, Michigan, in June 2020. There will be seven sessions on specific topics, each with three to four speakers and a discussion leader. At the end of the second day, there will be group discussion sessions to develop priorities for future research that will identify the research initiatives that will have the greatest impact on reducing risk and improving survival from this common disease.

摘要 子宫内膜癌发病率持续上升，是妇科最常见的恶性肿瘤， 美国的女人。令人沮丧的是，与大多数其他癌症不同， 几十年在生存率方面存在着明显的种族差异，非西班牙裔黑人妇女的生存率高于非西班牙裔黑人妇女。 无论诊断时的分期或组织学亚型，结局均最差。造成这种差异的原因， 其他知识差距，如监测高危妇女的方法，或了解生存率 子宫内膜癌的治疗方法有哪些？本次研讨会将汇集 来自流行病学、生物学、病理学、肿瘤学、遗传学和临床实践领域的专家， 交流知识和思想。在这次研讨会上产生的讨论将指导研究， 减少这种疾病的发病率、发病率和死亡率。 我们计划于2020年6月在密歇根州底特律举行为期两天的研讨会。将有七个会议， 每个小组有三到四名发言人和一名讨论负责人。第二天结束时， 将举行小组讨论会，以确定未来研究的优先事项， 这些举措将对降低这种常见疾病的风险和提高生存率产生最大影响。