Multi-System Evaluation of Massage Therapy on HIV+ Adolescents

青少年艾滋病毒按摩治疗的多系统评价

• 批准号: 7652414
• 负责人: Sheila Wang
• 金额: $ 12.91万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7652414
• 关键词: AIDS/HIV problem; Adolescent; Adult; Affect; Age-Years; Anti-Retroviral Agents; Area; Attention; Attitude; Behavioral; Belief; Books; Caring; Child; Childhood; Chronic; Clinic; Collaborations; Communicable Diseases; Complex; Degenerative Disorder; Disease; Disease Progression; Doctor of Philosophy; Educational Intervention; Effectiveness; Entropy; Ethics; Evaluation; Funding; HIV; HIV Infections; HIV Seropositivity; Hand; Health; Healthcare Systems; Heart Diseases; Highly Active Antiretroviral Therapy; Hormonal; Hormones; Hydrocortisone; Immune; Immunization; Immunology; Individual; Integrative Medicine; Intelligence; International; International Health Problems; Intervention; Iris; Life; Malignant Neoplasms; Massage; Measures; Medical; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Morals; National Center for Complementary and Alternative Medicine; Neuroendocrinology; Organism; Outcome; Outcomes Research; Patients; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physicians; Population; Property; Randomized Controlled Trials; Relaxation Therapy; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Severities; Special Hospitals; Structure; System; Systems Analysis; Systems Integration; Systems Theory; Target Populations; Therapeutic; Time; Training; Trust; Work; base; behavior measurement; biological systems; career development; cost; depressive symptoms; design; experience; health belief; heart rate variability; high risk; immune function; improved; interest; intervention effect; novel; professor; programs; response; tool; treatment effect

DESCRIPTION (provided by applicant): This REVISED Mentored Patient-Oriented Research Career Development Award proposal is designed to support the career development of Sheila Wang, PhD, and to provide important, new information on the impact of a CAM intervention, massage therapy, on multiple biologic parameters in HIV-infected adolescents, a high risk, underserved pediatric population. As many as one-half of all new HIV infections occur in persons under 25 years of age. Globally, there are 10 million children and adolescents living with HIV infection without access to highly active antiretroviral therapy (HAART), making it a compelling national and international health problem. While much attention has appropriately been focused on the urgent moral and ethical dilemma of providing medication to these people, we must simultaneously explore low cost, non- invasive strategies to enhance immune function for HIV-infected individuals who do not yet have access to HAART. Preliminary studies report immune enhancing effects of massage therapy for adolescents and children living with HIV infection. Relatively low cost CAM therapies, like massage, may have the potential to provide a safe, sustainable form of immunostimulation to children and adolescents while they are waiting for access to HAART and/or as an adjunct to pharmacotherapy. The proposed research utilizes a unique and novel multi-system evaluation of a massage therapy intervention that recognizes the complexity of biological systems and the impact of disease on multiple system interactions. This research project is a tool for career development and training including one on one mentoring from international experts Ram Yogev, MD (Pediatric/Adolescent HIV/AIDS and Immunology) and Iris Bell, MD, PhD, (Integrative Medicine); collaboration with Univ of IL professor Sue Carter, PhD (neuroendocrinology), "hands on" training experience in the Univ of IL lab of Stephen Porges, PhD (Heart Rate Variability); in the Northwestern Univ labs of Uri Wilensky, PhD and Luis Amaral, PhD (complex systems); and in the Children's Memorial Hospital Special Infectious Diseases Adolescent Clinic (Drs. Yogev and Garofalo). The research plan involves two components: 1) a preliminary randomized controlled trial of massage therapy vs relaxation training on immune, autonomic, hormonal and behavioral measures in HIV+ adolescents and 2) a comparison between multi-system response profiles of healthy and HIV+ adolescents.

描述（由申请人提供）：这项经过修订的注重患者的研究职业发展奖旨在支持Sheila Wang，PhD博士的职业发展，并提供有关CAM干预，按摩治疗，对艾滋病毒感染的青少年中多种生物学参数的影响的重要新信息，艾滋病毒感染的青少年，高风险，较高的养生者。所有新艾滋病毒感染的多达一半发生在25岁以下的人中。在全球范围内，有1000万儿童和青少年患有艾滋病毒感染的儿童和青少年，无法获得高度活跃的抗逆转录病毒疗法（HAART），这使其成为一个令人信服的国家和国际健康问题。尽管有很多关注的重点是为这些人提供药物的紧急道德和道德困境，但我们必须同时探索低成本，非侵入性策略，以增强尚未获得HAART的HIV感染者的免疫功能。初步研究报告说，按摩疗法对青少年和艾滋病毒感染儿童的免疫增强作用。相对低成本的CAM疗法（如按摩）可能有可能为儿童和青少年提供安全，可持续的免疫刺激形式，而他们正在等待进入Haart和/或作为药物治疗的辅助手段。拟议的研究采用了对按摩疗法干预措施的独特而新颖的多系统评估，该评估认识到生物系统的复杂性以及疾病对多种系统相互作用的影响。该研究项目是用于职业发展和培训的工具，包括来自国际专家Ram Yogev（小儿/青少年艾滋病毒/艾滋病和免疫学）的一对一指导，以及医学博士Iris Bell（Integrative Medicine）；与IL教授Sue Carter大学的合作，博士学位（神经内分泌学），“动手”培训经验在IL Lab of Stephen Porges，博士学位（心率可变性）的IL实验室中；在Uri Wilensky的西北大学实验室中，博士学位和Luis Amaral博士（复杂系统）；以及在儿童纪念医院特殊传染病中，青少年诊所（Yogev博士和Garofalo）。研究计划涉及两个组成部分：1）按摩治疗的初步随机对照试验与HIV+青少年的免疫，自主神经，荷尔蒙和行为测量的放松训练以及2）健康和HIV+青少年的多系统反应谱之间的比较。