Determinats of Body Composition in Rheumatoid Arthritis

类风湿关节炎身体成分的决定因素

• 批准号: 7662451
• 负责人: JON T GILES
• 金额: $ 13.47万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7662451
• 关键词: Abdominal Cavity; Accounting; Adipocytes; Adipose tissue; Adverse effects; Age-Years; Aging; Appearance; Area; Atherosclerosis; Baltimore; Biological Preservation; Biometry; Blood Vessels; Body Composition; Body Weight; Cachexia; Cardiovascular Diseases; Cardiovascular system; Central obesity; Chronic; Clinical; Clinical Investigator; Clinical Trials Design; Collaborations; Communities; Comorbidity; Confounding Factors (Epidemiology); Cross-Sectional Studies; Deposition; Energy Intake; Enrollment; Environment; Epidemiologic Methods; Evaluation; Event; Explosion; Face; Fatty acid glycerol esters; Fostering; Funding; Future; General Population; Head; Health; High Prevalence; Homeostasis; Hormones; Inflammation; Inflammatory; Insulin Resistance; Interleukin-1; Interleukin-6; Investigation; K-Series Research Career Programs; Leptin; Lesion; Light; Longitudinal Studies; Matched Group; Measures; Mediator of activation protein; Mentors; Mesentery; Metabolic; Metabolic syndrome; Metabolism; Modality; Morbid Obesity; Morbidity - disease rate; Muscle; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Obesity; Observational Study; Omentum; Organ; Outcome; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Physical activity; Play; Population; Prevalence; Relative (related person); Research; Research Personnel; Research Project Grants; Rheumatoid Arthritis; Risk; Risk Factors; Role; Serum; Severities; Skeletal Muscle; TNF gene; Tissues; Training; Training Programs; Visceral; Wasting Syndrome; Work; adipokines; adiponectin; base; cardiovascular disorder risk; cardiovascular risk factor; cost; cytokine; design; experience; immune function; interest; mortality; muscle form; normal aging; patient oriented; prospective; prototype; resistin; sarcopenia; skills; trend; volunteer

DESCRIPTION (provided by applicant): The primary objective of this Mentored Patient-Oriented Career Development Award is to develop the skills and experience required to become a successful independent clinical investigator. In order to attain this objective, a training program has been constructed to foster: 1. Advanced training in the methods of epidemiology, biostatistics, and clinical trial design 2. A superior research environment made up of senior clinical investigators and well recognized experts in fields related to the scientific proposal 3. The groundwork on which to build future research projects and collaborations The scientific objective of this proposal is to explore the determinants of altered body composition in rheumatoid arthritis (RA). In RA, lean body mass is 10-15% lower than in non-RA controls despite the preservation of body weight. This observation suggests a net gain in fat mass. This has not been confirmed, however, and no studies have examined regional patterns of fat and muscle distribution in RA. In particular, patterns of fat deposition, particularly fat localized to the abdominal cavity (visceral fat) has emerged as a potent predictor of metabolic syndrome and cardiovascular disease. Further, an increase in fat mass combined with a net loss in lean body mass, termed sarcopenic obesity, has been associated with metabolic syndrome, cardiovascular disease, and mortality in non-RA populations. The specific aims of this proposal are to: 1. Characterize body composition and identify the prevalence of sarcopenic, obesity, and sarcopenic obesity in patients with RA compared to matched non-RA controls 2. Characterize serum adipokine profiles, insulin resistance, and the prevalence of components of the metabolic syndrome in patients with RA compared to matched non-RA controls. 3. Identify the inflammatory and non-inflammatory factors associated with altered body composition phenotypes, adipokine profiles, and insulin resistance in patients with RA .

描述（由申请人提供）：这个以指导患者为导向的职业发展奖的主要目标是培养成为一名成功的独立临床研究者所需的技能和经验。为了实现这一目标，我们制定了一项培训计划，以培养：流行病学、生物统计学和临床试验设计方法方面的高级培训。由资深临床研究人员和科学建议相关领域公认的专家组成的优越研究环境。本提案的科学目标是探索类风湿关节炎（RA）中身体成分改变的决定因素。在类风湿性关节炎患者中，尽管保持了体重，但瘦体重比非类风湿性关节炎对照组低10-15%。这一观察结果表明脂肪量净增加。然而，这一点尚未得到证实，也没有研究检查RA中脂肪和肌肉分布的区域模式。特别是，脂肪沉积模式，特别是腹腔脂肪沉积（内脏脂肪）已成为代谢综合征和心血管疾病的有力预测因子。此外，在非类风湿性关节炎人群中，脂肪量的增加与瘦体重的净损失（称为肌肉减少型肥胖）与代谢综合征、心血管疾病和死亡率有关。本建议的具体目的是：1。描述RA患者的身体组成特征，并确定与匹配的非RA对照相比，RA患者中肌肉减少、肥胖和肌肉减少性肥胖的患病率2。将RA患者的血清脂肪因子谱、胰岛素抵抗和代谢综合征成分的患病率与匹配的非RA对照进行比较。3. 确定与类风湿关节炎患者体内成分表型改变、脂肪因子谱和胰岛素抵抗相关的炎症和非炎症因素。