SPECTROSCOPIC DIAGNOSIS OF ATHEROSCLEROSIS

动脉粥样硬化的光谱诊断

• 批准号: 8364133
• 负责人: ABIGAIL Susan HAKA
• 金额: $ 0.74万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364133
• 关键词: Amino Acids; Atherosclerosis; Biomedical Research; Characteristics; Clinical; Coronary artery; Diagnosis; Fluorescence; Fluorescence Spectroscopy; Foam Cells; Funding; Grant; Lasers; Lesion; Low-Density Lipoproteins; Methods; National Center for Research Resources; Principal Investigator; Proteins; Proteoglycan; Research; Research Infrastructure; Resources; Source; Tryptophan; United States National Institutes of Health; cost; oxidized low density lipoprotein; versican

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The protein components of low-density lipoprotein (LDL), oxidized LDL and proteoglycans such as versican contain tryptophan, an amino acid with characteristic fluorescence features at 308 nm excitation wavelength. We hypothesize that intrinsic fluorescence spectroscopy at 308 nm excitation wavelength IFS380, a method suitable for clinical use, can identify coronary artery lesions with superficial foam cells (SFCs) and/or proteoglycans.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 低密度脂蛋白 (LDL)、氧化 LDL 和蛋白聚糖（例如多功能蛋白聚糖）的蛋白质成分含有色氨酸，色氨酸是一种在 308 nm 激发波长下具有特征荧光特征的氨基酸。我们假设 308 nm 激发波长 IFS380 的内在荧光光谱是一种适合临床使用的方法，可以识别表面泡沫细胞 (SFC) 和/或蛋白聚糖的冠状动脉病变。