Sensory pathways for conditioned stimulus detection during avoidance behavior

回避行为期间条件刺激检测的感觉通路

• 批准号: 7537171
• 负责人: Manuel A Castro-Alamancos
• 金额: $ 29.38万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-15 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537171
• 关键词: Air; Animals; Anxiety; Behavior; Behavioral; Brain; Brain Stem; Cells; Complex; Conditioned Stimulus; Contralateral; Detection; Development; Emotional; Feedback; Fiber; Goals; Learning; Mediating; Midbrain structure; Mood Disorders; Neuromodulator; Operant Conditioning; Pathway interactions; Performance; Positioning Attribute; Process; Property; Prosencephalon; Research; Research Project Grants; Role; Sensory; Signal Transduction; Social Phobia; Stimulus; System; Tectum Mesencephali; Thalamic structure; Trigeminal System; Vibrissae; Work; avoidance behavior; base; classical conditioning; conditioning; depression; neuroregulation; novel; programs; relating to nervous system; response; sensory stimulus; sensory system; somatosensory; superior colliculus Corpora quadrigemina

DESCRIPTION (provided by applicant): Through associative learning, neutral sensory stimuli are transformed into behaviorally relevant conditioned stimuli that signal behavioral contingencies. In operant conditioning paradigms, conditioned stimuli must be detected by sensory systems and relayed to appropriate association centers in the brain. In the somatosensory system, primary sensory relay cells in the trigeminal complex produce two major ascending and contralateral somatosensory pathways. One innervates the thalamus in the forebrain (trigeminothalamic) and the other innervates the deep layers of the superior colliculus in the midbrain tectum (trigeminotectal). The role of these two ascending pathways in the detection of somatosensory stimuli that are behaviorally relevant, such as conditioned stimuli in an operant conditioning task, is not known. Here we propose that the superior colliculus is a major sensory relay that serves to detect behaviorally relevant sensory signals in operant conditioning paradigms but with less analytical capabilities than the thalamic sensory relay. These two relay systems (trigeminothalamic and trigeminotectal) work together to detect and identify sensory conditioned stimuli. Therefore, in addition to its well-known role in orienting to novel stimuli, the trigeminotectal pathway would be an essential part of the sensory circuitry responsible for the detection of conditioned stimuli that signal behavioral contingencies requiring immediate operant responses. There are two major goals in this project. The first goal is to determine the response properties and neuromodulation of superior colliculus cells. The second goal is to characterize the activity and response properties of these cells as animals detect behaviorally relevant sensory stimuli during performance in an active avoidance task. The long term goal of this research project is to reveal the neural substrates of a complex form of emotional conditioning, active avoidance, that has direct relevance to many anxiety and mood disorders, such as phobias, social anxiety and depression.Understanding the role of the superior colliculus and sensory thalamus in the processing of behaviorally significant stimuli during active avoidance behavior has direct relevance to anxiety and mood disorders, such as phobias, social anxiety and depression.

描述（由申请人提供）：通过联想学习，中性感官刺激被转化为行为相关的条件刺激，信号行为的偶然性。在操作性条件反射范式中，条件刺激必须被感觉系统检测到，并被传递到大脑中适当的联想中心。在躯体感觉系统中，三叉神经复合体中的初级感觉中继细胞产生两个主要的上行和对侧躯体感觉通路。一个神经支配前脑中的丘脑（三叉丘脑），另一个神经支配中脑顶盖中的上级丘深层（三叉顶盖）。这两个上行通路在检测行为相关的体感刺激（如操作性条件反射任务中的条件刺激）中的作用尚不清楚。在这里，我们建议，上级丘是一个主要的感觉中继，用于检测行为相关的感觉信号在操作性条件反射的范例，但分析能力比丘脑感觉中继。这两个中继系统（trigeminothalamic和trigeminotectal）一起工作，以检测和识别感官条件刺激。因此，除了其众所周知的作用，在定向到新的刺激，三叉神经顶盖途径将是一个重要的一部分，负责检测的条件刺激，信号的行为突发事件，需要立即操作性反应的感觉回路。这个项目有两个主要目标。第一个目标是确定上级丘细胞的反应特性和神经调节。第二个目标是表征这些细胞的活性和反应特性，因为动物在主动回避任务中检测行为相关的感觉刺激。本研究项目的长期目标是揭示一种复杂的情绪调节--主动回避--的神经基础，它与许多焦虑和情绪障碍，如恐惧症，社交焦虑和抑郁有直接关系。了解上级丘和感觉丘脑在主动回避行为过程中处理行为上重要刺激的作用与焦虑和情绪障碍有直接关系，例如恐惧症、社交焦虑症和抑郁症。