Development of an interference electroporation device to improve targeted cell pe
Development of an interference electroporation device to improve targeted cell pe
批准号:
8780288
负责人:
Richard Jason Connolly
金额:
$16.27万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-18 至 2016-09-17
关键词:
AddressAdverse effectsAlgorithmsAnimalsAntineoplastic AgentsBiological ProductsCancer PatientCancerousCellsCessation of lifeClinicalClinical ResearchClinical TreatmentClinical TrialsComputer SimulationComputer softwareDevelopmentDevicesDiseaseDisseminated Malignant NeoplasmEffectivenessElectroporationEnsureEquationFrequenciesFutureGenesImmunotherapyMedicalMethodsModelingOperative Surgical ProceduresOutcomePhaseQuality of lifeReportingResearchSignal TransductionSkin CancerSolid NeoplasmSolutionsStagingTechniquesTechnologyTestingTherapeutic AgentsTimeToxic effectTransfectionWorkalternative treatmentbasecancer cellcancer therapychemotherapydesignelectric fieldimprovedin vivoinstrumentinstrumentationmathematical analysismelanomamodel developmentneoplastic cellnovelnovel strategiesplasmid DNAproduct developmentprogramsprototypepublic health relevanceresearch studysimulationtreatment planningtumoruptake
中文摘要
描述(申请人提供):在这里,我们寻求开发一种更有效和更有针对性的电穿孔设备,用于临床治疗癌症实体瘤。在临床环境中,利用电穿孔技术将治疗剂导入肿瘤细胞是一种令人兴奋的癌症靶向治疗方法。这方面的挑战
工作是进一步开发一种临床电穿孔设备,它将利用波干扰现象来产生有针对性的电穿孔波形,以提高转基因的有效性。
英文摘要
DESCRIPTION (provided by applicant): Here we seek to develop a more effective and targeted electroporation device for the clinical treatment of cancerous solid tumors. The application of using electroporation to transfect therapeutic agents into a tumor cells in the clinician setting is an exciting approach to a targeted treatment of cancer. The challenge for this
work is to further develop a clinical electroporation device that will use the phenomenon of wave interference to produce a targeted electroporation waveform to increase the effectiveness of transfection.
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