开发干扰电穿孔装置以提高靶向细胞性能-猫眼课题宝

开发干扰电穿孔装置以提高靶向细胞性能

批准号：

8780288

负责人：

Richard Jason Connolly

金额：

$16.27万

依托单位：

ONCOSEC MEDICAL, INC.

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-09-18 至 2016-09-17

来源：

https://reporter.nih.gov/project-details/8780288

关键词：

Address Adverse effects Algorithms Animals Antineoplastic Agents Biological Products Cancer Patient Cancerous Cells Cessation of life Clinical Clinical Research Clinical Treatment Clinical Trials Computer Simulation Computer software Development Devices Disease Disseminated Malignant Neoplasm Effectiveness Electroporation Ensure Equation Frequencies Future Genes Immunotherapy Medical Methods Modeling Operative Surgical Procedures Outcome Phase Quality of life Reporting Research Signal Transduction Skin Cancer Solid Neoplasm Solutions Staging Techniques Technology Testing Therapeutic Agents Time Toxic effect Transfection Work alternative treatment base cancer cell cancer therapy chemotherapy design electric field improved in vivo instrument instrumentation mathematical analysis melanoma model development neoplastic cell novel novel strategies plasmid DNA product development programs prototype public health relevance research study simulation treatment planning tumor uptake

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英文摘要

DESCRIPTION (provided by applicant): Here we seek to develop a more effective and targeted electroporation device for the clinical treatment of cancerous solid tumors. The application of using electroporation to transfect therapeutic agents into a tumor cells in the clinician setting is an exciting approach to a targeted treatment of cancer. The challenge for this work is to further develop a clinical electroporation device that will use the phenomenon of wave interference to produce a targeted electroporation waveform to increase the effectiveness of transfection.

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Development of an interference electroporation device to improve targeted cell pe

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