Neurobiology of relaxin-3/RXFP3 systems: anatomical and functional studies in transgenic mice

relaxin-3/RXFP3 系统的神经生物学：转基因小鼠的解剖学和功能研究

• 批准号: nhmrc : 1017408
• 负责人: Mr Ihaia Hosken
• 金额: $ 6.28万
• 依托单位: Howard Florey Institute
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurobiology-relaxin-3rxfp3-transgenic-mice/109860
• 关键词: Neurobiology; relaxin; RXFP3; systems; anatomical

Mental illness is an economic and health burden worldwide, with huge costs in medical spending, lost productivity, poor quality of life for sufferers and mortality. Relaxin-3 is a peptide that acts widely within neural circuits to modulate brain activity that is altered in conditions such as anxiety and mood/sleep disorders. Our research assessing the effect of genetic removal of relaxin-3 signaling on behaviour will add to our knowledge of brain function and improve mental health outcomes.

精神疾病是世界范围内的经济和健康负担，医疗费用巨大，生产力损失，患者生活质量差，死亡率高。松弛素-3是一种肽，广泛作用于神经回路，以调节在焦虑和情绪/睡眠障碍等条件下改变的大脑活动。我们的研究评估了松弛素-3信号的遗传去除对行为的影响，这将增加我们对大脑功能的了解，并改善心理健康结果。