Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

主题 375：用于监测肿瘤对热疗免疫疗法反应的新型诊断成像方式（登月）

• 批准号: 9786928
• 负责人: Thomas E. Ramsay
• 金额: $ 29.97万
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-14 至 2019-06-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9786928
• 关键词: Affect; Algorithms; Breast Cancer Model; Complex; Computer software; Contracts; Diagnostic; Diagnostic Imaging; Diagnostic radiologic examination; Hyperthermia; Image; Immune system; Immunotherapy; Monitor; Patient Monitoring; Patients; Phase; Research; System; Tissue Sample; Treatment Efficacy; base; cancer immunotherapy; cancer therapy; experience; image processing; imaging modality; imaging software; innovation; microscopic imaging; mouse model; novel diagnostics; outcome forecast; response; tumor; tumor microenvironment

Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience in breakthrough software-based diagnostic imaging, will collaborate with Kaio Therapy (innovative hyperthermia platform for cancer immunotherapy) to marry powerful, innovative diagnostic image processing algorithms and hyperthermia immunotherapy. In the long term, this research is expected to provide a unique solution for a comprehensive and innovative diagnostic approach capable of evaluating efficacy of the treatment, monitoring patients' prognosis, and identifying patients who are likely to respond to the immunotherapy.

在过去的几十年中，免疫疗法已经成为癌症治疗的有力方法。然而，免疫系统是复杂的，并且治疗功效实质上受肿瘤微环境的影响。由于这个原因，目前难以可视化肿瘤反应并预测治疗效果。 在本合同中，Imago Systems，Inc.在突破性的基于软件的诊断成像方面拥有丰富经验的公司，将与Kaio Therapy（用于癌症免疫治疗的创新热疗平台）合作，将强大的创新诊断图像处理算法与热疗免疫治疗结合起来。 从长远来看，这项研究有望为全面和创新的诊断方法提供独特的解决方案，能够评估治疗效果，监测患者的预后，并确定可能对免疫疗法有反应的患者。