Neuroendocrine functions of PrRP, a novel hypothalamic peptide

新型下丘脑肽 PrRP 的神经内分泌功能

• 批准号: nhmrc : 102607
• 负责人: Jon Curlewis
• 金额: $ 12.26万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neuroendocrine-functions-prrp-hypothalamic-peptide/76061
• 关键词: Neuroendocrine; functions; PrRP; novel; hypothalamic

This project investigates the role of a newly discovered chemical (peptide) that is found in a part of the brain called the hypothalamus which regulates the activity of the pituitary gland. The hypothalamus and pituitary gland work together to control many of the body?s essential processes such as growth, metabolism and reproduction. Some human diseases are caused by abnormalities of the hypothalamus and pituitary gland while many other diseases affect the functions of these glands, leading to widespread complications such as weight loss, wasting, abnormal immune responses, infertility or failure of lactation. While many of the hormones and chemicals of the hypothalamus and pituitary gland have been extensively studied, recent advances in molecular biology have led to the discovery of new chemicals that may have important regulatory functions. One of these newly discovered substances which was named Prolactin-Releasing Peptide or PrRP is the topic of this project. PrRP will be tested in a series of experiments in animals in order to determine how important it is in regulating the pituitary gland, particularly in stress and during lactation which are conditions when PrRP could be secreted. It is hoped that this research will lead to a more detailed understanding of how the reproductive and endocrine system are controlled in humans and to new methods for the manipulation of these systems under normal and disease conditions.

该项目研究了一种新发现的化学物质（肽）的作用，这种化学物质存在于大脑的一个叫做下丘脑的部位，它调节脑垂体的活动。下丘脑和脑垂体共同控制身体的许多功能？的基本过程，如生长，新陈代谢和繁殖。一些人类疾病是由下丘脑和脑下垂体的异常引起的，而许多其他疾病影响这些腺体的功能，导致广泛的并发症，如体重减轻，消瘦，异常免疫反应，不育或哺乳失败。虽然下丘脑和脑垂体的许多激素和化学物质已被广泛研究，但分子生物学的最新进展导致发现了可能具有重要调节功能的新化学物质。其中一种新发现的物质被命名为催乳素释放肽或PrRP是该项目的主题。PrRP将在一系列动物实验中进行测试，以确定它在调节脑垂体中的重要性，特别是在应激和哺乳期间，这些条件是PrRP可以分泌的条件。希望这项研究将导致更详细地了解人类生殖和内分泌系统是如何控制的，以及在正常和疾病条件下操纵这些系统的新方法。