Interstitial Intensity Modulated Photodynamic Therapy Phase II

间隙强度调制光动力疗法第二期

• 批准号: 9789205
• 负责人: Mary Potasek
• 金额: $ 98.07万
• 依托单位: SIMPHOTEK, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789205
• 关键词: 3-Dimensional; Algorithms; Animal Model; Animals; Benchmarking; Blood Vessels; Cessation of life; Clinical; Clinical Research; Code; Computer software; Devices; Diffuse; Disease; Dose; Drug-sensitive; Elements; Ensure; Feedback; Fluorescence; Future; In Situ; Laboratories; Lasers; Light; Malignant Neoplasms; Manuals; Measurement; Measures; Mechanics; Medical Device; Modeling; Monitor; Mus; Neck; Nerve; Normal tissue morphology; Optics; Oryctolagus cuniculus; Oxygen; PUVA Photochemotherapy; Penetration; Performance; Phase; Photobleaching; Photosensitization; Physicians; Porfimer Sodium; Positioning Attribute; Power Sources; Process; Property; Radiation therapy; Roswell Park Cancer Institute; Singlet Oxygen; Source; Squamous Cell Neoplasms; Squamous cell carcinoma; Surface; System; Techniques; Technology; Thick; Time; Tissues; Treatment outcome; Update; animal tissue; base; cancer therapy; chemotherapy; clinically relevant; dosimetry; graphical user interface; improved; interstitial; light intensity; novel; oncology; patient safety; prototype; simulation; subcutaneous; success; systemic toxicity; treatment planning; triplet state; tumor

Photodynamic therapy (PDT) is a cancer treatment that utilizes visible or near-infrared light to activate a light- sensitive drug (photosensitizer, PS) that, in turn, creates reactive singlet oxygen species from ground triplet state oxygen that is present in the tumor. The resulting reactive products induce tissue death. Ideally the reactive species will be produced within only the target volume, leading to damage of the tumor or diseased tissues, while minimizing damage to surrounding normal tissue. Unlike chemotherapy, PDT does not cause systemic toxicities, and unlike radiation therapy it does not cause cumulative damage in the local field. When an external light beam is used to treat superficial surface or intracavitary surface cancers, the effective depth of light penetration and treatment is limited to < 10 mm. For deeply seated tumors or tumors that are more than 10 mm in thickness, intra-tumor light delivery (interstitial PDT, I-PDT) is required to activate the PS.

光动力疗法（PDT）是一种利用可见光或近红外光激活光离子的癌症治疗方法