Interstitial Intensity Modulated Photodynamic Therapy Phase II

间隙强度调制光动力疗法第二期

基本信息

  • 批准号:
    9789205
  • 负责人:
  • 金额:
    $ 98.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-06-01 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

Photodynamic therapy (PDT) is a cancer treatment that utilizes visible or near-infrared light to activate a light- sensitive drug (photosensitizer, PS) that, in turn, creates reactive singlet oxygen species from ground triplet state oxygen that is present in the tumor. The resulting reactive products induce tissue death. Ideally the reactive species will be produced within only the target volume, leading to damage of the tumor or diseased tissues, while minimizing damage to surrounding normal tissue. Unlike chemotherapy, PDT does not cause systemic toxicities, and unlike radiation therapy it does not cause cumulative damage in the local field. When an external light beam is used to treat superficial surface or intracavitary surface cancers, the effective depth of light penetration and treatment is limited to < 10 mm. For deeply seated tumors or tumors that are more than 10 mm in thickness, intra-tumor light delivery (interstitial PDT, I-PDT) is required to activate the PS.
光动力疗法(PDT)是一种利用可见光或近红外光激活光离子的癌症治疗方法

项目成果

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Mary Potasek其他文献

Mary Potasek的其他文献

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{{ truncateString('Mary Potasek', 18)}}的其他基金

Patient tailored near real-time image-based treatment for interstitial PDT of Inoperable Cancer with Airway Obstruction - Phase IIa
为患者量身定制基于近实时图像的间质 PDT 治疗,用于治疗伴有气道阻塞的无法手术癌症 - IIa 期
  • 批准号:
    10468238
  • 财政年份:
    2021
  • 资助金额:
    $ 98.07万
  • 项目类别:
Patient tailored near real-time image-based treatment for interstitial PDT of Inoperable Cancer with Airway Obstruction - Phase IIa
为患者量身定制基于图像的近实时治疗,用于治疗气道阻塞且无法手术的癌症的间质 PDT - IIa 期
  • 批准号:
    10325471
  • 财政年份:
    2021
  • 资助金额:
    $ 98.07万
  • 项目类别:
In situ PEDSy and light delivery platform for Intracavitory Photodynamic Therapy
用于腔内光动力治疗的原位 PEDSy 和光传输平台
  • 批准号:
    10266766
  • 财政年份:
    2020
  • 资助金额:
    $ 98.07万
  • 项目类别:
In situ PEDSy and light delivery platform for Intracavitory Photodynamic Therapy
用于腔内光动力治疗的原位 PEDSy 和光传输平台
  • 批准号:
    10674694
  • 财政年份:
    2020
  • 资助金额:
    $ 98.07万
  • 项目类别:
In situ PEDSy and light delivery platform for Intracavitory Photodynamic Therapy
用于腔内光动力治疗的原位 PEDSy 和光传输平台
  • 批准号:
    10439878
  • 财政年份:
    2020
  • 资助金额:
    $ 98.07万
  • 项目类别:

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