Developmental Research Program

发展研究计划

• 批准号: 9791703
• 负责人: ELISABETH IIJAS HEATH
• 金额: $ 7.25万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9791703
• 关键词: Applications Grants; Award; Basic Science; Budgets; Cancer Biology; Cancer Center; Clinical; Communities; Data; Development; Faculty; Funding; Goals; Grant; Institutes; Institution; Malignant Neoplasms; Malignant neoplasm of prostate; Manuscripts; Medical Students; Medicine; Mentors; Metastatic Neoplasm to the Bone; Michigan; Minority; Monitor; Morbidity - disease rate; Pathology; Patients; Peer Review; Peer Review Grants; Pilot Projects; Principal Investigator; Process; Program Research Project Grants; Prostate; Publications; Publishing; Research; Research Personnel; Research Proposals; Resources; Science; Seeds; Site; Translational Research; United States National Institutes of Health; Universities; Urologic Oncology; Urology; anticancer research; cancer clinical trial; career; cost; data submission; flexibility; graduate student; high reward; high risk; innovation; interest; member; mortality; oncology; oncology program; professor; programs; single cell analysis; summer student; undergraduate student

Recognizing that developmental research funds are an integral part of the SPORE, we commit approximately $150,000 per year to these endeavors. This represents a significant portion of the Prostate SPORE budget and reflects the continued commitment to the development of innovative translational research in prostate cancer. The focus of the Developmental Research Program (DRP) is to provide investigators the resources to generate preliminary data for the submission of an R01 grant application or an equivalent proposal. Investigators from outside the field of prostate cancer are encouraged to apply through campus-wide announcements as well as through personal interactions with the SPORE investigators. We developed a stepwise proposal solicitation and review process for pilot projects utilizing an NIH-type PHS 398 format that has been streamlined for rapid turnaround of research proposals and which recognizes that these projects may have little preliminary data. Since 1995, we have invested $3.9 million in our DRP, funding a total of 89 investigators though 77 pilot projects, 63 seed grants and 35 summer student projects. These awards have led to over $40 million in subsequent SPORE and non-SPORE peer-reviewed funding and over 136 published manuscripts. During this current grant cycle, we funded 9 pilot projects ($50K each) that led to over $9.7 million in subsequent peer-reviewed grant funding and 22 publications. Drs. Elisabeth Heath (Karmanos Cancer Institute, KCI) and Evan Keller (U- M) will serve as Co-Directors for the DRP. Dr. Heath is a Professor of Oncology and Medicine, at Wayne State University and Director of Prostate Cancer Research KCI. She is the Principal Investigator of the DOD-funded Prostate Cancer Clinical Trials Consortium where KCI is the leading site for overall patient and minority accrual in prostate cancer clinical trials. She has mentored numerous undergraduate students, medical students, cancer biology graduate students, and junior faculty members and will serve as a clinical expert. Dr. Keller is a Professor of Urology and Pathology, at UM, Co-Director of the Urologic Oncology program of the UM Rogel Cancer Center, directs an NIH-funded Program Project on Prostate Cancer Bone Metastasis and is Co-Director of the Single Cell Analysis Core and will serve as basic science expert. In this proposal, the DRP will be jointly supported by U-M and KCI. U-M will contribute $50,000 plus funds to cover effort for the U-M Co-Director. KCI will contribute $50,000 to support either a DRP or CEP award for a KCI investigator as well as funds to cover the KCI Co-Director. We are requesting the remaining $50,000 from NCI.

认识到发展研究基金是 SPORE 的一个组成部分，我们承诺大约 每年为这些努力投入 150,000 美元。这占前列腺孢子预算的很大一部分，并且 反映了对前列腺癌创新转化研究发展的持续承诺。 发展研究计划 (DRP) 的重点是为研究人员提供资源以产生 提交 R01 拨款申请或同等提案的初步数据。调查人员来自 鼓励前列腺癌领域以外的人通过全校公告以及 通过与 SPORE 调查员的个人互动。我们制定了逐步提案征集和 使用 NIH 型 PHS 398 格式进行试点项目的审查流程，该格式经过简化，可快速实现 研究提案的周转，并认识到这些项目可能没有什么初步数据。 自 1995 年以来，我们已在 DRP 中投资了 390 万美元，通过 77 个试点项目资助了总共 89 名研究人员， 63 项种子资助和 35 个暑期学生项目。这些奖项为后续项目带来了超过 4000 万美元的资金 SPORE 和非 SPORE 同行评审资助以及超过 136 篇已发表的手稿。在此电流期间 在资助周期中，我们资助了 9 个试点项目（每个项目 5 万美元），在随后的同行评审中筹集了超过 970 万美元 拨款和 22 种出版物。博士。 Elisabeth Heath（卡马诺斯癌症研究所，KCI）和 Evan Keller（U- M) 将担任 DRP 的联合主任。 Heath 博士是韦恩州立大学肿瘤学和医学教授 KCI 大学和前列腺癌研究主任。她是国防部资助的项目的首席研究员 前列腺癌临床试验联盟，其中 KCI 是总体患者和少数群体应计的领先网站 在前列腺癌临床试验中。她指导过许多本科生、医学生、癌症学生 生物学研究生和初级教员将担任临床专家。凯勒博士是一位教授 密歇根大学泌尿学和病理学博士，密歇根大学罗格尔癌症中心泌尿肿瘤学项目联席主任， 指导 NIH 资助的前列腺癌骨转移项目，并且是该项目的联合主任 细胞分析核心并将担任基础科学专家。在本提案中，DRP将得到共同支持 由密歇根大学和 KCI 提供。密歇根大学将捐赠 50,000 美元以上的资金来支持密歇根大学联合主任的工作。 KCI 将 捐款 50,000 美元以支持 KCI 调查员的 DRP 或 CEP 奖励以及用于支付的资金 KCI 联合董事。我们要求 NCI 提供剩余的 50,000 美元。