Training in HIV/AIDS Prevention and Treatment Research in Botswana

博茨瓦纳艾滋病毒/艾滋病预防和治疗研究培训

• 批准号: 10396618
• 负责人: SHAHIN LOCKMAN
• 金额: $ 30.06万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10396618
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Advisory Committees; Africa; Anti-Retroviral Agents; Botswana; Country; Developing Countries; Doctor of Philosophy; Educational workshop; Environment; Epidemic; Faculty; Funding; Goals; Government; HIV; Health; High Prevalence; Individual; Institutes; Institution; Journals; Modernization; Monitor; Patients; Performance; Persons; Pharmacotherapy; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention Research; Public Health Schools; Publications; Research; Research Activity; Research Personnel; Research Training; Safety; Site; Teacher Professional Development; Testing; Training; Training Programs; Treatment outcome; Universities; base; experience; faculty mentor; low and middle-income countries; pre-doctoral; programs; success; training opportunity; treatment program; treatment research

PROJECT ABSTRACT The focus for this proposal is research training for people from Botswana in relation to the various uses of ART for prevention and treatment in the modern era of the HIV epidemic. Recent advancements in coverage strategies and antiretroviral combinations within the Botswana national ART program offer a unique environment for use of modern HIV treatment, safety, and prevention research for the developing world, with a host of research opportunities for training researchers in Botswana, to match current research activities of the faculty mentors and key partners at the Botswana site. The in-country institution for this proposal is the Harvard T.H. Chan School of Public Health, and our LMIC partner for training is the Botswana Harvard AIDS Institute Partnership (BHP), a limited liability nonprofit corporation (LLC) with the Ministry of Health (MOH) in Botswana. BHP is the largest HIV/AIDS research organization in Botswana, and one of the largest in Africa. The long-term goals and objectives of this training program are to train research leaders for BHP, the University of Botswana, and the MOH. Botswana currently has one of the highest prevalence rates of HIV in the world (22%), but has also had the highest rate of antiretroviral drug treatment (ART) for patients with HIV (about 90%) in Africa. The government of Botswana currently operates the most advanced HIV treatment program in Africa, using a universal test-and-treat strategy. The training faculty at Harvard and BHP will focus on how “modern” ART impacts treatment outcomes, safety, and prevention research. HIV-related courses, seminars, and workshops are available for trainees. We have requested funds for 2 predoctoral and 3 postdoctoral positions each year. We estimate that we will train about 18 trainees over 5 years, allowing for multiple years for each PhD candidate and some postdoctoral fellows, and assuming several short-term trainees could fill a single annual training slot. Stipends will be based on current degrees and research experience; thus an MD on an MS or PhD program would be eligible for a postdoctoral-level stipend. Each trainee will have a principal advisor and a faculty advisory committee. Selection of trainees is based on previous academic performance, references, experience, and assurance that the candidates will return to participate in HIV research in Botswana. The quality of the program will be monitored by a Training Advisory Committee composed of experts from the US and from developing countries. The success of the training program will be judged by the relative increase in senior research positions at BHP, UB, and MOH that are individuals who were trained by this program after the second and fourth years. Success will also be judged by the implementation of successful prevention research programs that involve trainees, numbers of trainee publications in high-impact journals, and number of staff positions filled by former trainees at the BHP and the Ministry of Health.

项目摘要 该提案的重点是为博茨瓦纳人提供有关 ART 各种用途的研究培训 用于现代艾滋病流行的预防和治疗。覆盖范围的最新进展 博茨瓦纳国家 ART 计划中的策略和抗逆转录病毒组合提供了独特的 为发展中国家提供现代艾滋病毒治疗、安全和预防研究的环境， 为博茨瓦纳的研究人员提供大量研究机会，以配合博茨瓦纳当前的研究活动 博茨瓦纳基地的教师导师和主要合作伙伴。本提案的国内机构是 哈佛大学 T.H.陈公共卫生学院，我们的中低收入国家培训合作伙伴是博茨瓦纳哈佛艾滋病中心 Institute Partnership (BHP) 是一家与卫生部 (MOH) 合作的有限责任非营利公司 (LLC) 博茨瓦纳。必和必拓是博茨瓦纳最大的艾滋病毒/艾滋病研究组织，也是非洲最大的艾滋病毒/艾滋病研究组织之一。 该培训计划的长期目标和目标是为必和必拓（BHP）培训研究领导者 博茨瓦纳大学和卫生部。博茨瓦纳目前是艾滋病毒感染率最高的国家之一 世界上（22%），也是艾滋病毒患者接受抗逆转录病毒药物治疗（ART）率最高的国家 （约 90%）在非洲。博茨瓦纳政府目前采用最先进的艾滋病毒治疗方法 非洲的计划，采用通用的检测和治疗策略。哈佛大学和必和必拓的培训师将重点关注 关于“现代”ART 如何影响治疗结果、安全性和预防研究。 为学员提供与艾滋病毒相关的课程、研讨会和讲习班。我们已请求资金 2 每年招收博士前和博士后3名。我们预计将培训 5 岁以上学员约 18 名 年，允许每个博士候选人和一些博士后研究员有多年的时间，并假设 几个短期受训人员可以填补一个年度培训名额。津贴将基于当前学位 和研究经验；因此，硕士或博士课程的医学博士将有资格获得博士后级别 助学金。每个实习生都会有一名首席顾问和一个教职顾问委员会。实习生的选拔是 基于之前的学术表现、推荐信、经验以及候选人将做出的保证 返回博茨瓦纳参加艾滋病毒研究。该计划的质量将由培训机构进行监控 咨询委员会由来自美国和发展中国家的专家组成。的成功 培训计划将根据必和必拓、布法罗大学和卫生部高级研究职位的相对增长情况来判断 是在第二年和第四年之后接受该计划培训的个人。也将获得成功 通过实施涉及受训者的成功预防研究计划来判断， 受训者在高影响力期刊上发表的出版物，以及必和必拓前受训者担任的员工职位数量 和卫生部。