Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification

罗斯威尔公园开发新技术，通过基因组修饰进一步开展基于癌症的研究和治疗

• 批准号: 10733275
• 负责人: Aimee B Stablewski
• 金额: $ 32.49万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733275
• 关键词: Animal Model; Applications Grants; Area; Biology; Cancer Center; Cancer Center Support Grant; Cell Line; Cells; Collaborations; Comprehensive Cancer Center; Consult; Consultations; Dedications; Development; Developmental Therapeutics Program; Doctor of Philosophy; Ensure; Funding; Gene Targeting; Genetic; Genetically Modified Animals; Genome; Grant; Infrastructure; Investments; Laboratories; Malignant Neoplasms; Modification; Positioning Attribute; Principal Investigator; Privatization; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Scientist; Specialist; Stress; Technology; Transgenic Organisms; United States National Institutes of Health; Wages; base; cancer research center director; career; experience; genome editing; member; neoplasm immunotherapy; new technology; programs; tool; tumor immunology

Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Park Comprehensive Cancer Center (Roswell Park). This position was created in 1999 to oversee the research applications of the various genome editing platforms available in the resource and to apply her extensive experience in these areas in collaborations and consultations with the GeTT investigator user base. With over 25 years of experience in research applications of the creation of genetically modified animals and cells (23 years at Roswell Park), Dr. Stablewski throughout her career has collaborated with many investigators at the Cancer Center on NIH funded projects. The GeTT is an integral part of Roswell Park's Cancer Center Support grant (P30CA016056) for which the cancer center Director, Dr. Johnson, serves as the Principal Investigator. All three CCSG programs (Developmental Therapeutics (DT), Tumor Immunology and Immunotherapy (TII) and Cancer Stress Biology (CSB) equally make up the user base of the GeTT; and numerous NIH-funded researchers in these programs actively collaborate and consult with Dr. Stablewski. Dr. Stablewski' s contributions to Roswell Parks research enterprise have been significant and impactful specifically with regards to the NIH-funded research of the members of the TII program. As of September 2022, there are thirty-nine grant applications that cited use of the GeTT shared resources. There were twenty-six NIH/ NCI, two DOD, and the remaining applications include private and public funding sponsors, eleven of whom were TII Program members, fourteen are CSB members and nine are DT members. The cancer center has also made significant investments in the GeTT with regards to advancing technology in genetic modifications. With the changes in the R50 program now making the distinction between Laboratory (PAR-20-288) and Core (PAR-20-287) based scientists and with the GeTT being an integral part of the Roswell Park CCSG infrastructure, Dr. Johnson as the PI of the CCSG grant, will now serve as the Unit Director for the application.

摘要 目前的申请寻求Aimee Sablewski博士的工资支持，Aimee Sablewski博士担任 罗斯威尔公园综合癌症中心的基因打靶和转基因共享资源(GETT) (罗斯威尔公园)。这个职位设立于1999年，负责监督各种基因组的研究应用 资源中提供的编辑平台，并将她在这些领域的丰富经验应用于 与GETT调查员用户群进行协作和协商。拥有超过25年的工作经验 转基因动物和细胞的研究应用(在罗斯威尔公园工作了23年)。 在斯泰切夫斯基的整个职业生涯中，她与癌症中心的许多研究人员就NIH进行了合作 受资助的项目。Gett是罗斯威尔公园癌症中心支持赠款的组成部分(P30CA016056) 癌症中心主任约翰逊博士担任首席调查员。所有三个CCSG 方案(发展治疗学(DT)、肿瘤免疫学和免疫疗法(TII)和癌症应激 生物学(CSB)同样构成了GETT的用户基础；NIH资助的许多研究人员在这些 这些项目积极与斯泰切夫斯基博士合作并进行咨询。斯泰切夫斯基博士S对罗斯威尔公园的贡献 研究企业在美国国立卫生研究院资助的 TII计划的成员。截至2022年9月，有39份拨款申请引用了 Gett共享的资源。NIH/NCI有26个，国防部有2个，其余的申请 包括私人和公共供资赞助者，其中11人是TII方案成员，14人是公务员事务局 成员中有9名是DT成员。 癌症中心还在GETT上进行了大量投资，以推动 基因改造。随着R50计划的变化，现在实验室之间的区别 (PAR-20-288)和CORE(PAR-20-287)为基础的科学家，GETT是 罗斯威尔公园CCSG基础设施，约翰逊博士担任CCSG赠款的PI，现在将担任该股 应用程序的主管。