Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification

罗斯威尔公园开发新技术，通过基因组修饰进一步开展基于癌症的研究和治疗

• 批准号: 10733275
• 负责人: Aimee B Stablewski
• 金额: $ 32.49万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733275
• 关键词: Animal Model; Applications Grants; Area; Biology; Cancer Center; Cancer Center Support Grant; Cell Line; Cells; Collaborations; Comprehensive Cancer Center; Consult; Consultations; Dedications; Development; Developmental Therapeutics Program; Doctor of Philosophy; Ensure; Funding; Gene Targeting; Genetic; Genetically Modified Animals; Genome; Grant; Infrastructure; Investments; Laboratories; Malignant Neoplasms; Modification; Positioning Attribute; Principal Investigator; Privatization; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Scientist; Specialist; Stress; Technology; Transgenic Organisms; United States National Institutes of Health; Wages; base; cancer research center director; career; experience; genome editing; member; neoplasm immunotherapy; new technology; programs; tool; tumor immunology

Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Park Comprehensive Cancer Center (Roswell Park). This position was created in 1999 to oversee the research applications of the various genome editing platforms available in the resource and to apply her extensive experience in these areas in collaborations and consultations with the GeTT investigator user base. With over 25 years of experience in research applications of the creation of genetically modified animals and cells (23 years at Roswell Park), Dr. Stablewski throughout her career has collaborated with many investigators at the Cancer Center on NIH funded projects. The GeTT is an integral part of Roswell Park's Cancer Center Support grant (P30CA016056) for which the cancer center Director, Dr. Johnson, serves as the Principal Investigator. All three CCSG programs (Developmental Therapeutics (DT), Tumor Immunology and Immunotherapy (TII) and Cancer Stress Biology (CSB) equally make up the user base of the GeTT; and numerous NIH-funded researchers in these programs actively collaborate and consult with Dr. Stablewski. Dr. Stablewski' s contributions to Roswell Parks research enterprise have been significant and impactful specifically with regards to the NIH-funded research of the members of the TII program. As of September 2022, there are thirty-nine grant applications that cited use of the GeTT shared resources. There were twenty-six NIH/ NCI, two DOD, and the remaining applications include private and public funding sponsors, eleven of whom were TII Program members, fourteen are CSB members and nine are DT members. The cancer center has also made significant investments in the GeTT with regards to advancing technology in genetic modifications. With the changes in the R50 program now making the distinction between Laboratory (PAR-20-288) and Core (PAR-20-287) based scientists and with the GeTT being an integral part of the Roswell Park CCSG infrastructure, Dr. Johnson as the PI of the CCSG grant, will now serve as the Unit Director for the application.

摘要 目前的申请寻求Aimee Stablewski博士的工资支持，他担任该公司的董事。 Roswell Park综合癌症中心的基因打靶和转基因共享资源（GeTT） （Roswell Park）该职位于1999年设立，负责监督各种基因组的研究应用。 编辑平台中提供的资源，并应用她在这些领域的丰富经验， 与GeTT调查员用户群的合作和协商。拥有超过25年的经验， 研究应用的创造转基因动物和细胞（23年在罗斯韦尔公园），博士。 Stablewski在她的职业生涯中与NIH癌症中心的许多研究人员合作 资助的项目。GeTT是罗斯韦尔公园癌症中心支持补助金（P30 CA 016056）的一个组成部分。 癌症中心主任约翰逊博士担任主要研究者。所有三个CCSG 程序（发育治疗学（DT），肿瘤免疫学和免疫治疗（TII）和癌症压力 生物学（CSB）同样构成了GeTT的用户群;许多NIH资助的研究人员在这些领域 项目积极与Stablewski博士合作和咨询。Stablewski博士对罗斯威尔公园的贡献 研究企业已经显着和有影响力，特别是关于美国国立卫生研究院资助的研究， TII计划的成员。截至2022年9月，有39个赠款申请引用了使用 共享的GeTT资源。有26个国家卫生研究院/国家癌症研究所，两个国防部，其余的申请 包括私人和公共资金赞助者，其中11人是TII计划成员，14人是CSB 9人，9人是党员。 癌症中心还在GeTT方面进行了大量投资，以推进技术， 基因改造随着R50计划的变化，实验室 （PAR-20-288）和核心（PAR-20-287）的科学家，GeTT是 罗斯韦尔公园CCSG基础设施，约翰逊博士作为PI的CCSG赠款，现在将担任该股 主任的申请。