University of Pennsylvania Patient-derived Xenograft Development and Trials Center

摘要： 宾夕法尼亚大学PDX开发和试验中心的管理核心的目标是 主要是促进创新的翻译科学，这将加速将新发现应用于 为癌症患者开设的诊所。这将通过加强两方面的发展相结合来实现 通过促进与PDXNet的互动，在宾夕法尼亚大学推广独特的PDX型号。行政部门 CORE将负责确保UP-PDTC作为PDXNet的一个研究单位有效发挥作用。这个 行政核心的主要职责是提供科学的领导、行政服务、 和财务监督，并作为与方案支助委员会有关的所有活动的沟通中心。这个 行政核心将为项目1-2、PDX核心、试点项目的调查人员和人员提供支持 和跨网络核心，以及生物统计学核心。行政核心将至少每年安排一次 UP-PDTC的SAB会议。值得一提的是，行政核心协调所有支持 多样性、公平和包容性，包括确保和促进所有少数群体在 UP-PDTC开发的组织库和PDX模型。管理核心提供以下每个功能 这些小组为他们的活动提供集中的组织和支持，并帮助每个小组了解情况 关于与UP-PDTC相关的活动、会议、机会和其他信息。行政部门 CORE将负责与PDXNet人员(PDXNet指导委员会)以及 NCI人员，并将为所有协作提供支持。特别是，行政核心将促进 UP-PDTC人员与PDXNet数据共享中心和管理中心之间的互动。 工作人员提供的支持的连续性将导致高效率和高成效地管理上一级军事技术委员会。

Summary: The goal of the Administrative Core of the University of Pennsylvania PDX Development and Trials Center is primarily to facilitate innovative translational science that will accelerate the application of new discoveries to the clinic for cancer patients. This will be achieved through a combination of enhancing both the development of unique PDX models at UPENN and through facilitating interaction with the PDXNet. The Administrative Core will be responsible to make sure that the UP-PDTC acts effectively as a research unit of PDXNet. The primary responsibilities of the Administrative Core are to provide scientific leadership, administrative services, and financial oversight, as well as to function as a communication hub for all UP-PDTC-related activities. The Administrative Core will support investigators and personnel in Projects 1-2, the PDX Core, the Pilot Projects and Trans-Network Core, and the Biostatistical Core. The Administrative Core will arrange at least annual meetings of the SAB of the UP-PDTC. Of note, the Administrative Core coordinates all efforts in support of diversity, equity, and inclusion, including ensuring and facilitating wide representation of all minority groups in the tissue banks and PDX models developed by the UP-PDTC. The Administrative Core provides each of these groups with centralized organization and support for their activities, and helps each group stay informed about activities, meetings, opportunities, and other information pertinent to the UP-PDTC. The Administrative Core will be responsible for communication with PDXNet personnel (PDXNet Steering Committee) as well as NCI personnel and will provide support for all collaborations. In particular, the Administrative Core will facilitate interactions between UP-PDTC personnel and the PDXNet Data Commons and Administrative Center. Continuity of support provided by the staff will result in efficient and effective administration for the UP-PDTC.