Core 1: Clinicopathological Analysis and Disease Modeling

临床病理分析及疾病建模核心综述 临床病理分析和疾病建模核心(核心B)的主要目标是催化 纽约大学朗格尼健康(NYULH)转移研究网络中心的研究目标由 提供高质量的、带临床注释的黑色素瘤生物标本、人类和动物组织的专业知识 分析和尖端技术资源。 为了执行NYULH转移研究网络中心的中心科学战略，核心B将1) 获取小鼠交叉验证所需的回顾和预期黑色素瘤患者样本 动物模型测试的数据和假设生成，2)改进尖端成像技术 多光谱免疫荧光分析，以及3)在术后病理评估方面提供专业知识 实验小鼠和人体组织支持3个主要项目以及试点项目。通过一个 治理委员会，核心B还将提供对生物杀虫剂使用的监督。利用以下资源： NYULH黑色素瘤计划包括最近获得的孢子，核心B将服务于NYULH 转移研究网络中心社区以及网络的其他中心，避免重复 提高工作效率，最大限度地提高成本效益和效率。 总体而言，Core B将提供高质量的、带注释的黑色素瘤患者生物样本、尖端技术 为所有中心研究提供资源和病理专业知识，以支持NYULH转移研究网络 中心的使命是发现黑色素瘤转移的决定因素，重点是早期扩散的驱动因素 以及与微环境组件的串扰。

CLINICOPATHOLOGICAL ANALYSIS AND DISEASE MODELING CORE SUMMARY The primary objective of the Clinicopathological Analysis and Disease Modeling Core (Core B) is to catalyze the New York University Langone Health (NYULH) Metastasis Research Network Center’s research goals by providing high-quality, clinically annotated melanoma biospecimens, expertise in human and animal tissue analyses, and cutting-edge technological resources. To execute the central scientific strategy of the NYULH Metastasis Research Network Center, Core B will 1) procure both retrospective and prospective melanoma patient samples needed for cross-validation of murine data and hypothesis generation for animal model testing, 2) refine cutting-edge imaging technologies for multispectral immunofluorescence analyses, and 3) provide expertise in the pathological assessment of post- experimental mouse and human tissues to support the 3 main projects as well as pilot projects. Through a governance committee, Core B will also provide oversight of biospecimen use. Leveraging the resources of NYULH Melanoma Program including the recently awarded SPORE, Core B will serve both the NYULH Metastasis Research Network Center community as well as other Centers of the Network, avoiding duplication of efforts and maximizing cost-effectiveness and efficiency. Overall, Core B will provide high quality, annotated melanoma patient biospecimens, cutting-edge technological resources, and pathological expertise to all Center studies to support the NYULH Metastasis Research Network Center’s mission to uncover determinants of melanoma metastasis, focused on drivers of early dissemination and cross-talk with micro-environmental components.