Core 1: Clinicopathological Analysis and Disease Modeling

核心 1：临床病理学分析和疾病建模

• 批准号: 10705098
• 负责人: Iman Osman
• 金额: $ 26.09万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705098
• 关键词: American; Animal Model; Artificial Intelligence; Award; Biological; Clinical; Collaborations; Data; Disease model; Ensure; Generations; Genetic Engineering; Goals; Health; Human; Human Resources; Imaging technology; Immunofluorescence Immunologic; Institution; International; Link; Mission; Modeling; Molecular; Mus; Neoplasm Metastasis; New York; Pathogenicity; Pathologic; Pathologist; Pathology; Patients; Pilot Projects; Process; Quality Control; Research; Research Infrastructure; Research Project Grants; Resources; Role; Sampling; Services; Societies; Technology; Testing; Translational Research; Universities; Validation; Work; Xenograft procedure; animal tissue; cancer type; college; community center; cost effective; cost effectiveness; digital; human tissue; innovation; melanoma; member; mouse model; new technology; novel; programs; prospective; repository; success; transcriptomics; tumor

CLINICOPATHOLOGICAL ANALYSIS AND DISEASE MODELING CORE SUMMARY The primary objective of the Clinicopathological Analysis and Disease Modeling Core (Core B) is to catalyze the New York University Langone Health (NYULH) Metastasis Research Network Center’s research goals by providing high-quality, clinically annotated melanoma biospecimens, expertise in human and animal tissue analyses, and cutting-edge technological resources. To execute the central scientific strategy of the NYULH Metastasis Research Network Center, Core B will 1) procure both retrospective and prospective melanoma patient samples needed for cross-validation of murine data and hypothesis generation for animal model testing, 2) refine cutting-edge imaging technologies for multispectral immunofluorescence analyses, and 3) provide expertise in the pathological assessment of post- experimental mouse and human tissues to support the 3 main projects as well as pilot projects. Through a governance committee, Core B will also provide oversight of biospecimen use. Leveraging the resources of NYULH Melanoma Program including the recently awarded SPORE, Core B will serve both the NYULH Metastasis Research Network Center community as well as other Centers of the Network, avoiding duplication of efforts and maximizing cost-effectiveness and efficiency. Overall, Core B will provide high quality, annotated melanoma patient biospecimens, cutting-edge technological resources, and pathological expertise to all Center studies to support the NYULH Metastasis Research Network Center’s mission to uncover determinants of melanoma metastasis, focused on drivers of early dissemination and cross-talk with micro-environmental components.

临床病理学分析和疾病建模核心摘要 临床病理学分析和疾病建模核心（Core B）的主要目的是催化 纽约大学朗格尼健康（NYULH）转移研究网络中心的研究目标， 提供高质量的，临床注释的黑色素瘤生物标本，人类和动物组织的专业知识 分析和尖端技术资源。 为了执行NYULH转移研究网络中心的核心科学战略，核心B将1） 获得交叉验证小鼠黑色素瘤的回顾性和前瞻性患者样本 动物模型测试的数据和假设生成，2）完善尖端成像技术， 多光谱免疫荧光分析，和3）提供专业知识的病理评估后， 实验小鼠和人体组织，以支持3个主要项目以及试点项目。通过 管理委员会，核心B还将监督生物标本的使用。充分利用 NYULH黑色素瘤计划，包括最近授予的孢子，核心B将服务于NYULH 转移研究网络中心社区以及网络的其他中心，避免重复 并最大限度地提高成本效益和效率。 总的来说，核心B将提供高质量的、带注释的黑色素瘤患者生物标本，尖端技术 资源和病理学专业知识，以支持所有中心的研究，以支持NYULH转移研究网络 中心的使命是揭示黑色素瘤转移的决定因素，重点关注早期传播的驱动因素 和与微环境成分的串扰。