Neuronal copper homeostasis and the role of the Alzheimer Amyloid-Beta Precursor Protein (APP)

神经元铜稳态和阿尔茨海默病淀粉样β前体蛋白 (APP) 的作用

• 批准号: nhmrc : 520345
• 负责人: Dr Michael Cater
• 金额: $ 19.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neuronal-copper-homeostasis-protein-app/115785
• 关键词: Neuronal; copper; homeostasis; role; Alzheimer

Alzheimer’s disease (AD) is creating a growing burden upon Australian medical resources. Copper plays an important role in the development of AD and drugs designed to adjust brain copper levels are being tested for AD treatment and show therapeutic benefits. This project will determine how copper is involved in AD so that more effective drugs can be developed. Focus will primarily be on copper-binding proteins central to AD and establishing their role in AD development and progression.

阿尔茨海默病（AD）正在给澳大利亚的医疗资源造成越来越大的负担。铜在AD的发展中起着重要作用，旨在调节脑铜水平的药物正在测试AD治疗并显示出治疗益处。该项目将确定铜如何参与AD，以便开发更有效的药物。重点将主要放在铜结合蛋白的核心AD和建立自己的作用，在AD的发展和进展。