课题基金 / 基金详情

F-box proteins: deregulated cell cycle control and proteolysis in cancer

F-box proteins: deregulated cell cycle control and proteolysis in cancer
F-box 蛋白：癌症中细胞周期控制和蛋白水解失调
批准号：
8001326
负责人：
MICHELE PAGANO
金额：
$44.65万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-07-01 至 2016-05-31
来源：
https://reporter.nih.gov/project-details/8001326
关键词：
AffectAnimal ModelAreaArtsBasic ScienceBiochemicalBiologicalBreastBreast Cancer CellBreast CarcinomaBreast LymphomaCancer BiologyCancer PatientCancer cell lineCell CycleCell Cycle ProgressionCell Cycle RegulationCell ProliferationCell SurvivalCell divisionCell physiologyCellsCellular biologyCircadian RhythmsClock proteinCommitDataDatabasesDevelopmentDimensionsDominant-Negative MutationDown-RegulationElementsEnsureEpithelialEpitheliumEstrogen ReceptorsEventF-Box ProteinsFailureFamilyFundingGenesGeneticGenetic TranscriptionGoalsGrowthGrowth and Development functionHumanHuman PathologyInstructionKnowledgeLaboratoriesLeadLifeLigaseLymphoidLymphomaMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of prostateManuscriptsMediatingMethodsMolecularMusMutant Strains MiceMutationNormal tissue morphologyOncogene ProteinsOrganOutcomePathway interactionsPlayPreparationProcessPrognostic MarkerProteasome InhibitorProteinsProteolysisProto-OncogenesPublicationsRegulationRelative (related person)ResearchRoleS PhaseSamplingSignal TransductionSolidSomatic CellSomatic Cell GeneticsSystemTherapeuticTherapeutic InterventionTimeTissuesTransgenic MiceTranslational ResearchTumor BankTumor Cell LineTumor Suppressor GenesTumor Suppressor ProteinsUbiquitinUbiquitin-mediated Proteolysis PathwayUnited States National Institutes of HealthWorkbasecancer therapycell growthcell transformationcircadian pacemakercyclin Fgenetic regulatory proteinhydroxyureain vivoinhibitor/antagonistinterdisciplinary approachmalignant breast neoplasmmammary epitheliummouse modelmultidisciplinarymutantneoplasticnoveloverexpressionpreclinical studyprognosticprogramssmall moleculesuccesstissue culturetooltumortumorigenesisubiquitin ligase

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