New aminobenzimidazole antimalarial agents with a novel mechanism of action

点击翻译按钮获取中文摘要

Malaria is a disease with a globally significant burden and distribution, including a presence in Australia’s northern neighbours East Timor, Indonesia and Papua New Guinea. Resistance to all major classes of antimalarial drugs has emerged in Asia in the last decade, meaning new antimalarials with unique mechanisms of action are urgently needed. This project seeks to identify the novel mechanism of action responsible for the activity of a new class of aminobenzimidazole antimalarials.