Leveraging experimental and computational tools to define molecular functions of non-coding RNAs in innate immune responses to viral infection
Leveraging experimental and computational tools to define molecular functions of non-coding RNAs in innate immune responses to viral infection
批准号:
10005115
负责人:
Sagi Shapira
金额:
$20.63万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-01 至 2021-08-31
关键词:
AlgorithmsAnimalsAntiviral AgentsCRISPR/Cas technologyCell LineCellsCollaborationsComputing MethodologiesDataEmbryoEpithelial CellsExperimental DesignsFibroblastsGene Expression ProfilingGenesGeneticGenetic TranscriptionHeterogeneityHumanImmune responseImmunologicsIn VitroInfluenza A virusInnate Immune ResponseInterferonsKnock-outLaboratoriesMediatingMicroRNAsMolecularMolecular TargetMusNF-kappa BNatural ImmunityNucleic AcidsPathway interactionsProteinsRNARegulationRegulonResearchResearch PersonnelRespiratory SystemRodentRoleSignal TransductionSmall Interfering RNASmall Nucleolar RNATRIM25 geneUntranslated RNAVertebratesViralVirus Diseasesantiviral immunityattenuationbasechromatin modificationcomputational platformcomputer infrastructurecomputerized toolsdesignexperimental studygain of functionin silicoin vivoinfluenzavirusinsightknock-downloss of functionoverexpressionprogramspromoterreconstructionresponseviral RNAvirtualvirus host interaction
中文摘要
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英文摘要
We seek to characterize the roles and functions of newly identified lncRNA ZFAS1 and its
SNORDs both in vitro and in vivo contexts of viral infection and nucleic acid sensing.
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会议论文
Quantitative studies of influenza evolution
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批准号:8615424
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项目类别:
-
资助金额:$51.64万
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财政年份:2014
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负责人:Sagi Shapira
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依托单位:
Quantitative studies of influenza evolution
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批准号:8791913
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项目类别:
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资助金额:$47.88万
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财政年份:2014
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负责人:Sagi Shapira
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依托单位:
海外基金