Low-cost mobile colposcopy and confocal imaging for global prevention of cervical cancer
低成本移动阴道镜和共焦成像在全球宫颈癌预防中的应用
基本信息
- 批准号:10031954
- 负责人:
- 金额:$ 61.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AblationAcetic AcidsAlgorithmic AnalysisAlgorithmsAreaBiomedical EngineeringBiopsyBrazilCancer CenterCancer EtiologyCancer HospitalCellular PhoneCervicalCervical Intraepithelial NeoplasiaCervix UteriCessation of lifeClinicalClinical ResearchCold TherapyCollaborationsColposcopesColposcopyCountryCytologyDetectionDevicesDiagnosisDiagnosticDiseaseEquipmentExcisionFiber OpticsGoldHPV-High RiskHealth SciencesHospitalsHuman PapillomavirusHuman ResourcesImageImage AnalysisImaging technologyIncidenceInfrastructureInstitutionInstructionLeadLesionMalignant NeoplasmsMalignant neoplasm of cervix uteriMedicalMedical ImagingMedically Underserved AreaMedicineModelingMorbidity - disease rateMultimodal ImagingNuclear AtypiaPathologyPatientsPerformancePrevention programProviderResearch PersonnelResolutionResourcesRiceSensitivity and SpecificityServicesSiteSpecificityTestingThermal Ablation TherapyTimeTrainingUnited StatesUniversitiesUniversity of Texas M D Anderson Cancer CenterVisitVisualWomanWorld Health Organizationaccurate diagnosisautomated algorithmautomated image analysisautomated visual evaluationbasecancer epidemiologycancer preventioncancer therapycervical biopsycervical cancer preventioncollegeconfocal imagingcostdigitalexperiencefollow-upglobal healthhigh resolution imagingimage archival systemimaging capabilitiesimaging modalityimaging probeimprovedindustry partnerinnovationlow and middle-income countriesmicroendoscopemicroscopic imagingmorphometrymortalitymultimodalitynuclear imagingovertreatmentpoint of carepremalignantprogramsprospectivepublic health relevancescreeningscreening programstandard of caretooltreatment programusability
项目摘要
Abstract:
Cervical cancer was once the leading cause of cancer death among women in the United States (U.S.).
The implementation of comprehensive programs for screening, diagnosis, and treatment over the past 60
years has reduced cervical cancer incidence and mortality by more than 70% in the U.S. In contrast, cervical
cancer remains the 1st or 2nd leading cause of cancer death among women in many low-and middle-income
countries (LMICs). Cervical cancer prevention programs in low-resource settings are hampered by a lack of
personnel with appropriate clinical expertise, lack of pathology services, and lack of associated infrastructure.
Programs that involve multiple patient visits have a high rate of loss to follow-up. Screen-and-Treat
approaches have been implemented in LMICs and include screening by HPV testing or visual inspection with
acetic acid (VIA) followed by immediate treatment, reducing loss to follow-up; but these approaches lead to
massive over-treatment due to the poor specificity of VIA and HPV testing. There is an urgent need for
appropriate diagnostic tools to enable the implementation of a sensitive and specific Screen-Diagnose-Treat
strategy that can be performed in a single patient visit in LMICs and in medically underserved areas of the U.S.
We propose to develop and validate a low-cost Multimodal Mobile Colposcope (MMC) for global cervical
Screen-Diagnose-Treat programs. This new device will combine the imaging capabilities of a smartphone-
based colposcope developed by MobileODT with the microscopic imaging capabilities of a fiber-optic confocal
imaging probe developed by Rice University. The MMC will image the entire cervix, automatically identify
suspicious regions, and acquire co-registered high-resolution images of nuclear morphometry from suspicious
areas. Multimodal image analysis algorithms will be developed in a study of 300 women referred for
colposcopy at two sites in Brazil. The performance of the MMC with automated image analysis for detection of
cervical precancer will be validated in a study of an additional 760 women referred for colposcopy in Brazil.
We will determine the feasibility and usability of the MMC among low-resource setting providers by carrying out
cancer prevention training courses using the MMC in Brazil.
Our academic-industrial partnership includes expertise in bioengineering (Rice University), colposcopy and
medical imaging (MobileODT), cervical cancer prevention and treatment (MD Anderson Cancer Center), and
cervical cancer prevention and epidemiology (Albert Einstein College of Medicine), as well as the clinical
expertise of our Brazilian clinical partners: Barretos Cancer Hospital and the Federal University of Health
Sciences of Porto Alegre/Hospital Santa Casa. The innovative imaging technologies to be developed in this
proposal will enable effective single-visit Screen-Diagnose-Treat programs to diagnose and treat women with
cervical precancer while minimizing overtreatment.
文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Rebecca R. Richards-Kortum其他文献
A novel method for semi-quantitative detection of HPV16 and HPV18 mRNA with a low-cost, open-source fluorimeter
- DOI:
10.1007/s00216-025-05765-8 - 发表时间:
2025-02-07 - 期刊:
- 影响因子:3.800
- 作者:
Kathryn A. Kundrod;Mary E. Natoli;Chelsey A. Smith;Jackson B. Coole;Megan M. Chang;Emilie Newsham Novak;Elizabeth Chiao;Elizabeth A. Stier;Jane R. Montealegre;Michael E. Scheurer;Philip E. Castle;Kathleen M. Schmeler;Rebecca R. Richards-Kortum - 通讯作者:
Rebecca R. Richards-Kortum
A paper-based HPV E7 oncoprotein assay for cervical precancer detection at the point of care
- DOI:
10.1038/s41598-024-79472-2 - 发表时间:
2025-01-24 - 期刊:
- 影响因子:3.900
- 作者:
Chelsey A. Smith;Sai Paul;Karen E. Haney;Sonia G. Parra;Meaghan Bond;Leticia López;Mauricio Maza;Juan Felix;Preetha Ramalingam;Pablo Escobar;Philip E. Castle;Kathleen M. Schmeler;Rebecca R. Richards-Kortum - 通讯作者:
Rebecca R. Richards-Kortum
A High-Resolution Microendoscope Improves Esophageal Cancer Screening and Surveillance: Implications for Underserved Global Settings Based on an International Randomized Controlled Trial
基于一项国际随机对照试验,高分辨率微型内窥镜改善了食管癌筛查和监测:对服务不足的全球环境的影响
- DOI:
10.1053/j.gastro.2024.10.025 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:25.100
- 作者:
Mimi C. Tan;Zhengqi Li;Kalpesh K. Patel;Fan Zhang;Xinying Yu;Xueshan Wang;Daniel G. Rosen;Sanford M. Dawsey;Liyan Xue;Chin Hur;Richard A. Schwarz;Imran Vohra;Yubo Tang;Mengfen Wu;Tao Wang;Jennifer Carns;Hong Xu;Rebecca R. Richards-Kortum;Guiqi Wang;Sharmila Anandasabapathy - 通讯作者:
Sharmila Anandasabapathy
Rebecca R. Richards-Kortum的其他文献
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{{ truncateString('Rebecca R. Richards-Kortum', 18)}}的其他基金
A Sample-to-Answer Point-of-Care Diagnostic for Recently Transfused Sickle Cell Anemia Patients in Low Resource Settings
针对资源匮乏地区最近输血的镰状细胞性贫血患者的从样本到答案的护理点诊断
- 批准号:
10564553 - 财政年份:2023
- 资助金额:
$ 61.45万 - 项目类别:
The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC) - Administrative Core
公平癌症护理护理点技术创新与转化中心 (CITEC) - 行政核心
- 批准号:
10715741 - 财政年份:2023
- 资助金额:
$ 61.45万 - 项目类别:
Point-of-care HPV mRNA test for cervical cancer screening in low-resource settings
在资源匮乏地区进行宫颈癌筛查的护理点 HPV mRNA 检测
- 批准号:
10331882 - 财政年份:2021
- 资助金额:
$ 61.45万 - 项目类别:
Low-cost mobile colposcopy and confocal imaging for global prevention of cervical cancer
低成本移动阴道镜和共聚焦成像用于全球宫颈癌预防
- 批准号:
10672941 - 财政年份:2020
- 资助金额:
$ 61.45万 - 项目类别:
Low-cost mobile colposcopy and confocal imaging for global prevention of cervical cancer
低成本移动阴道镜和共焦成像在全球宫颈癌预防中的应用
- 批准号:
10219206 - 财政年份:2020
- 资助金额:
$ 61.45万 - 项目类别:
Low-cost mobile colposcopy and confocal imaging for global prevention of cervical cancer
低成本移动阴道镜和共聚焦成像用于全球宫颈癌预防
- 批准号:
10406973 - 财政年份:2020
- 资助金额:
$ 61.45万 - 项目类别:
High resolution imaging & HPV oncoprotein detection for global prevention of cerv
高分辨率成像
- 批准号:
8912437 - 财政年份:2014
- 资助金额:
$ 61.45万 - 项目类别:
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