Studies of Thyroid Function in Health and Disease

健康和疾病中的甲状腺功能研究

• 批准号: 10011456
• 负责人: Joanna Klubo-Gwiezdzinska
• 金额: $ 5.23万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10011456
• 关键词: Age; Antibodies; Autoimmunity; Binding Proteins; Biological; Biological Assay; Blood; Board Certification; Body Composition; Clinical; Diagnosis; Diagnostic Procedure; Differentiation and Growth; Discipline of Nuclear Medicine; Disease; Endocrine; Endocrinology; Energy Metabolism; Enrollment; Etiology; Failure; Family history of; Functional disorder; Genetic; Graves' Disease; Health; Hyperthyroidism; Hyperthyroxinemia; Hypothalamic Hormones; Hypothalamic structure; Hypothyroidism; Iatrogenesis; Immunoassay; Institutes; Iodides; Laboratories; Laboratory Study; Magnetic Resonance Imaging; Measurement; Metabolism; Natural History; Patients; Pattern; Physical Examination; Pituitary Gland; Pituitary Neoplasms; Prolactinoma; Protocols documentation; Public Health; Radioactive Iodine; Recording of previous events; Recruitment Activity; Reflex action; Resistance; Scanning; Secondary to; Serum; Signs and Symptoms; Somatotropin; Spectrophotometry; Subacute thyroiditis; Technetium; Testing; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroid Nodule; Thyroid Stimulating Hormone Secreting Pituitary Gland Adenoma; Thyroiditis; Thyrotropin-Releasing Hormone; Thyroxine-Binding Globulin; Training; Training Programs; Trophoblastic Neoplasms; United States National Institutes of Health; Urine; X-Ray Computed Tomography; cell growth; cohort; diagnostic accuracy; glycosylation; imaging study; patient screening; receptor; research study; tumor; uptake

Subjects of any age with known or suspected thyroid abnormalities are actively recruited to this natural history protocol. The disorders studied can be broadly defined as hyper- or hypothyroid states and laboratory abnormalities. Hyperthyroid states include but are not restricted to Graves' disease with or without extrathyroidal manifestations; subacute thyroiditis; silent thyroiditis; single or multiple hyperfunctioning thyroid nodules; iodide-induced hyperthyroidism; surreptitious administration of thyroid hormone; trophoblastic neoplasms; "inappropriate" secretion of TSH arising from TSH- producing pituitary tumors or from a non-neoplastic cause, i.e. pituitary resistance to the action of thyroid hormone. Hypothyroid states include primary thyroid failure due to agenesis, autoimmunity or iatrogenic causes; secondary (or pituitary) hypothyroidism, usually resulting from tumors of the pituitary of non-thyrotropic origin such, as growth hormone (GH)-secreting tumors or prolactinomas; tertiary (or hypothalamic) hypothyroidism, usually resulting from a deficiency in the hypothalamic hormone thyrotropin-releasing hormone (TRH), either of unknown etiology or secondary to a pituitary tumor; bio-inactive TSH, either relating to an endogenous abnormality of hypothalamic hormones or secondary to pituitary tumors (and usually related to abnormal glycosylation patterns of the TSH molecule); generalized resistance to thyroid hormone (RTH), a disease which has been shown to be due to abnormalities in the TH receptor. Additionally, conditions or states that result in abnormal thyroid function tests are studied including non-thyroidal illness; abnormalities of serum TH binding proteins leading to euthyroid hyperthyroxinemia or hypertriiodothyronemia; genetic deficiency of thyroxine-binding globulin (TBG); antibody interference in TSH or other thyroid hormone assays. Recently, reflex mass spectrophotometry is utilized to further diagnose the thyroid dysfunction in this cohort of patients, thus enabling comparison of diagnostic accuracy between the mass spectrophotometry and standard immunoassays in diagnosing thyroid disorders.

已知或怀疑有甲状腺异常的任何年龄的受试者都被积极招募到这一自然病史方案中。所研究的疾病可以广泛地定义为甲状腺机能亢进或甲状腺功能减退状态和实验室异常。 甲亢状态包括但不限于伴有或不伴有甲状腺外表现的Graves病；亚急性甲状腺炎；静止性甲状腺炎；单个或多个功能亢进的甲状腺结节；碘诱导的甲亢；偷偷给药甲状腺激素；滋养细胞肿瘤；由产生促甲状腺激素的垂体瘤或非肿瘤性原因引起的促甲状腺激素的“不适当”分泌，即对甲状腺激素作用的抵抗。 甲状腺功能低下包括由于发育不全、自身免疫或医源性原因导致的原发性甲状腺功能衰竭；继发性(或垂体)甲状腺功能减退症，通常由非促甲状腺原发肿瘤引起，如生长激素(GH)分泌肿瘤或催乳素瘤；第三(或下丘脑)甲状腺功能减退症，通常由下丘脑激素释放激素(TRH)缺乏引起，原因不明或继发于脑垂体瘤；生物不活跃的促甲状腺激素(TSH)，要么与内源性下丘脑激素异常有关，要么继发于脑垂体瘤(通常与TSH分子的异常糖基化模式有关)；全身性甲状腺激素抵抗(RTH)，这是一种已被证明是由于TH受体异常引起的疾病。 此外，还研究了导致甲状腺功能测试异常的条件或状态，包括非甲状腺疾病；导致正常甲状腺功能亢进或高三碘甲状腺原氨酸血症的血清TH结合蛋白异常；甲状腺激素结合球蛋白(TBG)遗传缺陷；TSH或其他甲状腺激素检测中的抗体干扰。最近，反射质谱仪被用来进一步诊断这组患者中的甲状腺功能障碍，从而能够比较质谱仪和标准免疫分析在诊断甲状腺疾病方面的诊断准确性。