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Establishing the Pathways Between Diabetes and Cardiac Dysfunction: Epidemiology, Biomarkers, and Imaging

建立糖尿病和心脏功能障碍之间的途径：流行病学、生物标志物和影像学

基本信息

批准号：
10039436
负责人：
Justin Basile Echouffo Tcheugui
金额：
$ 19.82万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10039436
关键词：
Adult Animals Atherosclerosis Risk in Communities Biological Markers Biostatistical Methods Blood Circulation Cardiac Cardiovascular Diseases Cardiovascular system Characteristics Clinic Clinical Research Communities Competence Complement Coronary Coronary Arteriosclerosis Data Data Collection Development Diabetes Mellitus Diagnosis Doctor of Philosophy EFRAC Early Diagnosis Elderly Endocrinology Endothelin-1 Endothelium Epidemiologic Methods Epidemiology Five-Year Plans Functional disorder Funding Future Goals Grant Heart failure Hospitals Human Hyperglycemia Image Imaging Techniques Incidence Individual Inflammation Inflammatory Injury Intervention Investigation Lead Link Measures Mentored Patient-Oriented Research Career Development Award Mentors Metabolism Microvascular Dysfunction Molecular Myocardial Myocardial dysfunction Non-Insulin-Dependent Diabetes Mellitus Participant Pathogenicity Pathology Pathway interactions Patient Recruitments Patients Performance Phenotype Physicians Plasma Plasminogen Activator Inhibitor 1 Play Positioning Attribute Positron-Emission Tomography Prediabetes syndrome Prevention Preventive Prospective cohort Proteins Proteomics Research Research Design Research Proposals Risk Sampling Scientist Series Statistical Models Stress Structure System Techniques Training United States National Institutes of Health Universities Ventricular Dysfunction Ventricular Remodeling Work aptamer base cardiovascular risk factor career clinical biomarkers cohort design diabetic endothelial dysfunction experience follow-up heart imaging imaging approach imaging biomarker improved innovation medical schools metabolic imaging myocardial injury novel novel marker preservation prevent professor programs recruit research study skills

项目摘要

PROJECT SUMMARY/ABSTRACT Justin Echouffo Tcheugui, MD, PhD is an Assistant Professor in the Division of Endocrinology at the Johns Hopkins University School of Medicine. He seeks a K23 Mentored Patient-Oriented Research Career Development Award to obtain essential skills and mentored research experience for an independent career as a physician scientist in the field of metabolism and cardiovascular diseases. His research proposal details a five-year plan, with an overarching goal of achieving a clinical, biomarker and imaging characterization of diabetes-related cardiac dysfunction including an identification of key pathways of pathogenicity, in a large community-based cohort of black and white adults, and in a clinic-based sample of individuals with diabetes. The specific aims of the research are: 1) Assess the association of hyperglycemia with longitudinal changes in cardiac structure and function, and incidence and progression of heart failure and its subtypes; 2) Identify novel molecular pathways underlying the occurrence of diabetes-related cardiac dysfunction, using a plasma proteomic approach; 3) Evaluate whether coronary microvascular disease is a specific marker of diabetes- related cardiac dysfunction, using a dual investigative approach including cardiac positron emission tomography (PET) and circulation biomarkers of microvascular dysfunction. This study will inform heart failure prevention and treatment among individuals with diabetes, as it may identify novel biomarkers associated with diabetes-related cardiac dysfunction that can enhance our understanding of pathophysiology and serve as potential targets for interventions in future studies. Concurrent to the proposed research, the applicant will have tailored, in-depth didactic and hands-on training in advanced epidemiologic and biostatistics methods, biomarker and proteomics research, and in cardiac PET as an investigative imaging technique, as well as develop expertise in the design and performance of clinical studies, by leading data collection in a new cohort. The acquired skills will fill key training gaps for the applicant, thereby positioning Dr. Echouffo Tcheugui for a successful independently funded research career. His long-term goals are to establish a research program aimed at advancing the understanding of cardiovascular complications in diabetes, and informing future strategies for cardiovascular risk prediction and prevention among individuals with diabetes.

项目总结/文摘