Informatics Core

信息学核心项目总结 天然产物(NP)-药物相互作用(NPDI)研究跨越几个学科，包括来源和 候选NP材料的表征(分析核心)、NPDI易感性的体外和临床评估 (药理学核心)和数据传播(信息学核心)。NPDI现有的卓越中心 研究(NaPDI中心)，目前是其成功的第五年，由世界知名的专家组成，每个专家 这些领域，并为NPDI研究提供领导。信息学核心已经创建了基于云的数据 为手动NPDI研究数据输入和发布提供安全工作流程的存储库。该存储库是一个 如何使NPDI数据可查找、可访问、可互操作和可重用(公平)的领先示例。长的- 数据储存库的长期可持续性取决于其对相关利益攸关方的有用性。信息学 此续订应用程序的核心组件提出了三个具体目标，以优化数据存储库和 扩大NaPDI中心的信息学能力。目标1：核心将向数据存储库添加功能，以 增加其对不断增长的NPDI研究人员社区的有用性，包括配套的R21受赠者。是这样的 功能包括基于简单易用的数据输入表单和 使用通用数据格式的Web服务。新的数据汇总和可视化将为研究人员提供 一个完整的基于证据的概述，每个NP的潜力，以沉淀药代动力学NPDI。目标2： 药理核心以前开发了一种高效而稳健的方法，称为支点模型，用于 选择核动力源并确定其优先次序，作为核动力源的潜在沉淀物。这一新模式的应用目前是一种 耗时的手工任务。信息学核心将通过发展信息学来创新支点模式- 加快应用支点模型所需数据的收集和汇总的基于方法，提供 向中心和外部核动力源研究人员自动持续评估高优先级核动力源。《核心》 还将创新NPs的识别，使用来自 毒物中心报告和两个FDA不良事件报告系统。这一新功能将为研究人员提供 对报告的不良事件类型和涉及核燃料的伴随暴露有重要的洞察力。目标 3：信息学核心将扩大两个研究界对数据储存库的使用和效用 和临床实践利益相关者。为了在NPDI研究中吸引跨学科的科学家，我们 将扩大我们的营销战略。捕获临床实践利益相关者，这些利益相关者在 药物订购和对账活动，我们将设计NPDI临床决策支持产品和 通过以用户为中心的方法提供服务，灵感来自于潜在药物决策支持方面的最新进展 药物相互作用。这些目标的实现将导致一个学习的NPDI研究系统，它将得到改进 通过帮助患者避免非传染性疾病感染，促进公共卫生。

PROJECT SUMMARY OF THE INFORMATICS CORE Natural product (NP)-drug interaction (NPDI) research spans several disciplines that include sourcing and characterizing candidate NP materials (Analytical Core), in vitro and clinical assessment of NPDI liability (Pharmacology Core), and data dissemination (Informatics Core). The existing Center of Excellence for NPDI Research (NaPDI Center), currently in its fifth successful year, consists of world-renowned experts in each of these areas and provides leadership for NPDI research. The Informatics Core has created a cloud-based data repository that provides a secure workflow for manual NPDI study data entry and publishing. The repository is a leading example of how to make NPDI data findable, accessible, interoperable, and reusable (FAIR). The long- term sustainability of the data repository is dependent on its usefulness to relevant stakeholders. The Informatics Core component of this renewal application proposes three SPECIFIC AIMS that refine the data repository and expand the informatics power of the NaPDI Center. AIM 1: The Core will add features to the data repository to increase its usefulness for a growing community of NPDI researchers, including companion R21 grantees. Such features include a streamlined external data submission process based on simple-to-use data entry forms and web services that use a common data format. New data summaries and visualizations will provide researchers a complete evidence-based overview of each NP’s potential to precipitate pharmacokinetic NPDIs. AIM 2: The Pharmacology Core previously developed a highly effective and robust method, termed the fulcrum model, for selecting and prioritizing NPs as potential precipitants of NPDIs. Application of this novel model is currently a time-consuming manual task. The Informatics Core will innovate the fulcrum model by developing an informatics- based method to expedite the collection and summarization of data needed to apply the fulcrum model, providing an automated and continual appraisal of high priority NPs to the Center and external NP researchers. The Core will also innovate the identification of NPs by generating pharmacovigilance signal data for NPs using data from poison center reports and two FDA adverse event reporting systems. This new feature will provide researchers with important insight into the types of reported adverse events and concomitant exposures involving NPs. AIM 3: The Informatics Core will broaden the usage and utility of the data repository for both the research community and clinical practice stakeholders. To capture scientists across the spectrum of disciplines in NPDI research, we will expand our marketing strategy. To capture clinical practice stakeholders who consider potential NPDIs during medication ordering and reconciliation activities, we will design NPDI clinical decision support artifacts and services through a user-centered approach inspired by recent advances in decision support for potential drug- drug interactions. Accomplishment of these aims will result in a learning NPDI research system that will improve public health by helping patients avoid NPDIs.