(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented Research

镰状细胞病(SCD)是一种遗传性溶血性贫血，与认识不足有关。 发育迟缓和认知缺陷。慢性贫血，低氧饱和度，睡眠- 呼吸紊乱、脑梗塞和社会经济地位低下是 临床上显著的认知障碍。然而，SCD可能是一种看不见的残疾。 患者的发育没有得到常规的筛查，缺陷可能仍未得到诊断。早些时候 童年是筛选延迟的最重要的时间，因为孩子们可以接受 以证据为基础和联邦授权的资源，在进入之前补救发展 学校。如果没有这样的资源，这一弱势群体很有可能陷入贫困 学术成就、失业和监禁。当前的长期目标是 该项目是为患有SCD的幼儿做好早期教育的准备，并持续 学业上的成功。为了实现这一目标，金博士建议研究实施 对患有SCD的幼儿进行发育筛查，这是一个典型的被忽视的人群。Dr。 金是镰状细胞病实施中U01拨款的首席研究员 为患有SCD的青少年提供认知筛查和干预的联盟。她领衔 一组血液学家，一名神经心理学家，一名社会心理学家，职业治疗师， 和实施科学家进行干预和研究实施情况 科学成果，以“扩大”循证实践。她将利用这一既定的 完成以下目标的基础设施：目标1.确定障碍和促进者 0~3岁儿童SCD儿童早期发育监测与筛查 和目标2.确定具体的执行战略，以消除障碍和促进者 到儿童早期发展筛查。结果将通知适当的干预措施 改进SCD儿童的发育筛查。这项建议将加强金博士的 通过让她获得必要的技能来招募、教育和指导一名干部 卫生专业人员专注于实施科学，以改善临床和教育 SCD的转归。金博士在指导学生、实习生和少年方面有着长期的记录 来自多个科学学科的教师，包括医学、公共卫生、心理学、 教育和职业治疗。她对辅导工作特别感兴趣 她将继续这样做，以培养未来的领导人。

Sickle cell disease (SCD) is an inherited hemolytic anemia associated with under-recognized developmental delay and cognitive deficits. Chronic anemia, low oxygen saturations, sleep- disordered breathing, cerebral infarcts, and low socioeconomic status are risk factors for clinically significant cognitive impairments. However, SCD can be an invisible disability. Patients’ development is not routinely screened and deficits may remain undiagnosed. Early childhood is the most important time to screen for delays because children can receive evidence-based and federally mandated resources to remediate development before entering school. Without such resources, this vulnerable population has a high probability of poor academic attainment, unemployment, and incarceration. The long-term goal of the current project is to prepare young children with SCD for early childhood education and sustained academic success. To achieve this, Dr. King proposes to study the implementation of developmental screening of young children with SCD, a typically overlooked population. Dr. King is the principal investigator of a U01 grant in the Sickle Cell Disease Implementation Consortium to provide cognitive screening and intervention for adolescents with SCD. She leads a team of hematologists, a neuropsychologist, a social psychologist, occupational therapists, and implementation scientists to both conduct interventions and study the implementation science outcomes in order to “scale up” evidence-based practices. She will use this established infrastructure to complete the following aims: Aim 1. To determine the barriers and facilitators of surveillance and screening of early childhood development of children with SCD age 0-3 years, and Aim 2. To identify specific implementation strategies to address the barriers and facilitators to early childhood development screening. The results will inform the appropriate intervention to improve developmental screening in children with SCD. This proposal will enhance Dr. King’s career by allowing her to gain the necessary skills to recruit, educate, and mentor a cadre of health professionals focused on implementation science for improving clinical and educational outcomes in SCD. Dr. King has a long track record of mentoring students, trainees, and junior faculty from multiple scientific disciplines including medicine, public health, psychology, education, and occupational therapy. She has a particular interest in mentoring underrepresented minorities, and she will continue to do so to develop future leaders.