IU Training Program in Molecular Physiology and Clinical Mechanisms of Lung Disease

项目总结/摘要 该申请目前已进入第10年，是“分子生物学培训计划”的竞争性更新。 肺疾病的生理学和临床机制”，这是作为一个组合的成人和 印第安纳州大学（CAPPRI）的儿科肺部研究培训项目。该方案是独一无二的， 综合成人和儿童肺科，检查整个生命周期的疾病。我们的使命 是培养杰出的MD和博士科学家在调查事业的领导。为了定位未来 为了实现这一目标，我们的培训计划（CAPPRI）旨在使学员能够有一个全面的， 综合的，正式的职业发展经验，目标是将他们定位为下一个 肺和重症监护研究的一代领导者。CAPPRI强调转化科学， 将最新的科学平台和教学培训与细胞、动物模型和人类相结合， 组织研究与既定的临床研究计划。正规的研究生院培训可通过 印第安纳州临床和转化科学研究所（CTSI）。有33名教师导师和7名新兴 来自9个部门的导师。包括7个新兴导师（EM）是为了提供连续的 为CAPPRI提供指导和领导力发展。CAPPRI是围绕选定的主题亲和力而设计的 组（TAG）。五个TAG包括：1）血管生物学，包括成人和儿科介绍， 疾病; 2）结果和卫生服务; 3）气道生物学，包括生命周期的连续性; 4） 炎症、损伤和修复;以及5）发育机制。为了建立可持续发展的劳动力，我们将使用 学术坚持的概念模型作为我们的理论框架。2009-2019年，22名T32学员 有18人完成了培训。83.3%留在学术医学或相关研究领域。 该小组出版了147部同行评审作品。该小组已获得25项赠款，其中包括8项 奖学金，5个职业发展奖和3个NIH R 01奖。学员是高度多样化的， 50%的女性。所有这些因素使印第安纳州大学成为培养未来领导者的理想场所， 呼吸道疾病的影响。

PROJECT SUMMARY / ABSTRACT This application, currently in the 10th year, is a competitive renewal of the “Training Program in Molecular Physiology and Clinical Mechanisms of Lung Disease”, which is implemented as a Combined Adult and Pediatrics Pulmonary Research-training program at Indiana University (CAPPRI). The program is unique in synthesizing the adult and pediatric Pulmonary Divisions to examine diseases across the lifespan. Our mission is to train exceptional MD and PhD scientists for leadership in investigative careers. In order to position the future generation for this goal, our training program (CAPPRI) is designed to enable Trainees to have a comprehensive, integrative, and formal career development experience with the goal of positioning them to become the next generation of leaders in Pulmonary and Critical Care research. The CAPPRI stresses translational science, incorporating the newest scientific platforms and didactic training integrated with cell, animal model, and human tissue research with established clinical research programs. Formal graduate school training is available through the Indiana Clinical and Translational Sciences Institute (CTSI). There are 33 Faculty Mentors and 7 Emerging Mentors from 9 Departments. The inclusion of 7 emerging mentors (EM) is to provide the continuum of mentorship and leadership development for the CAPPRI. CAPPRI is designed around selected Thematic Affinity Groups (TAGs). The five TAGs include: 1) Vascular Biology, including both adult and pediatric presentations of disease; 2) Outcomes and Health Services; 3) Airway Biology encompassing the continuum of the lifespan; 4) Inflammation, Injury and Repair; and 5) Developmental Mechanisms. For a sustainable workforce, we will use a conceptual model of academic persistence as our theoretical framework. Between 2009-2019, 22 T32 Trainees were supported, with 18 completing their training. 83.3% remain in academic medicine or related research fields. The group has published 147 peer-reviewed works. This group has been awarded 25 grants, including 8 fellowship awards, 5 career development awards, and 3 NIH R01 awards. The Trainees are highly diverse, with 50% women. All of these factors enable the Indiana University to be an ideal site for training future leaders in respiratory diseases across the lifespan.