Administration and Regulation of Activities associated with The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical Discovery

摘要-行政核心 我们建议将范德比尔特泌尿系感染库（VUIR）作为宿主病原体的第一种资源 发现，一个系统地连接[1]来自大量患者的医疗数据，这些患者患有 泌尿道感染（UTIs）到[2]一个实际致病微生物的生物库。作为一种信息学和生物学 网络，VUIR将促进新的诊断和治疗策略，以打击尿路感染，同时提供一个 工具来阐明其潜在的发病机制。与此同时，鉴于VUIR的广泛范围， 多学科创新的潜力-需要一个强大的行政基础，以协调 该计划的日常活动，并实现其科学愿景。为此， VUIR将是其相关的行政核心（AdCore），这是一个定义的组织人员结构， 成功AdCore的教师领导团队在临床泌尿学方面拥有广泛的专业知识（Douglass博士 克莱顿），微生物发病机理（玛丽亚Hadjifrangiskou博士），和临床病理学/实验室医学（博士。 Jonathan Schmitz），并得到当地执行委员会和外部咨询委员会的进一步支持。 这些小组同样将包括来自信息学家、传染病专家、 医院流行病学家和微生物组专家，从 该计划将在多个领域做出贡献。AdCore还将纳入专门的后勤支持 来自学术和财务管理方面具有广泛背景的专业人士，以及网站 设计和活动管理。总的来说，这个小组将确保我们的后勤行动既积极主动， 和响应，协调互动和传播标本/数据内外范德比尔特。的 AdCore将在VUIR和精准医疗的互补机构结构之间创造协同效应 和翻译发现，以及冠军试点项目，建立在VUIR资源。我们的最终目标， 然而，它的目标是建立一个由美国各地的附属合作者、临床医生和研究人员组成的网络， 他们既可以从数据和标本的组合财富中受益，也可以为之做出贡献。最后，除了 支持科学创新，AdCore将确保我们在教育领域发展伴随的足迹， 的服务.通过工作坊、研讨会和沉浸式体验相结合，我们将在全国范围内建立联系， 泌尿生殖道感染生物学专家，从本科生到博士后/临床 伙计们除了内容领域的教育，这些互动将促进网络和职业发展 经验，包括代表性不足群体的个人的机会。超越自我 在学术界，AdCore将在现有的范德比尔特项目的基础上，促进与更大社区的联系 向公众宣传我们的科学使命。这样，VUIR的行政基础将 最大限度地发挥该计划的能力，以产生发现，同时传播信息，以广泛和多样化的 受众

SUMMARY - ADMINISTRATIVE CORE We propose the Vanderbilt Urologic Infection Repository (VUIR) as a first-in-kind resource for host-pathogen discovery, one that systematically connects [1] medical data from a vast number of patients who suffer from urinary tract infections (UTIs) to [2] a biobank of the actual causative organisms. As an informatic and biologic network, the VUIR will facilitate novel diagnostic and therapeutic strategies to combat UTIs, while providing a tool to elucidate their underlying pathogenesis. At the same time—given the extensive scope of the VUIR and its potential for multidisciplinary innovation—the need arises for a strong administrative foundation to coordinate the program's daily activities and bring to fruition its scientific vision. To these ends, a critical strength of the VUIR will be its associated Administrative Core (AdCore), a defined personnel structure for organizational success. The faculty leadership team of the AdCore holds broad expertise in clinical urology (Dr. Douglass Clayton), microbial pathogenesis (Dr. Maria Hadjifrangiskou), and clinical pathology/laboratory medicine (Dr. Jonathan Schmitz), further supported by both a Local Executive Committee and External Advisory Committee. These groups will likewise include strategic representation from informaticians, infectious disease specialists, hospital epidemiologists, and microbiome experts, providing ongoing thematic direction to the VUIR from the diverse fields to which the program will contribute. The AdCore will also incorporate dedicated logistical support from professionals with extensive background in academic and financial administration, as well as web-site design and event management. In total, this group will ensure that our logistical operations are both proactive and responsive, coordinating interactions and disseminating specimens/data within and beyond Vanderbilt. The AdCore will create synergy between the VUIR and complementary institutional structures for precision medicine and translational discovery, as well as champion pilot projects that build upon VUIR resources. Our ultimate goal, however, is to create a network of affiliated collaborators across the United States, clinicians and investigators who could both benefit from and contribute to the combined wealth of data and specimens. Finally, in addition to supporting scientific innovations, the AdCore will ensure we develop a concomitant footprint in education and service. Through a combination of workshops, seminars, and immersive experiences, we will connect nationwide experts in urogenital infection-biology to diverse trainees, from undergraduate students to postdoctoral/clinical fellows. In addition to content-area education, these interactions will foster networking and career-development experiences, including opportunities for individuals from underrepresented groups. And reaching beyond academia, the AdCore will promote outreach to the larger community, building on existing Vanderbilt programs to educate the public on our scientific mission. In this way, this administrative foundation of the VUIR will maximize the program's ability to generate discoveries, while disseminating information to broad and varied audiences.