Administration and Regulation of Activities associated with The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical Discovery

摘要--行政核心 我们建议范德比尔特泌尿系统感染库(VUIR)作为宿主病原体的首个同类资源 发现，一个系统地连接来自大量患者的医疗数据的发现 尿路感染(UTI)到[2]实际致病微生物的生物库。作为信息学和生物学家 通过VUIR网络，VUIR将促进新的诊断和治疗策略，以对抗尿路感染，同时提供 工具，以阐明其潜在的发病机制。同时--鉴于VUIR的广泛范围和 其多学科创新的潜力--需要一个强大的行政基础来协调 该计划的日常活动和实现其科学愿景。为了达到这些目的， VUIR将成为其关联的管理核心(AdCore)，这是为组织定义的人员结构 成功。AdCore的教师领导团队在临床泌尿学方面拥有广泛的专业知识(道格拉斯博士 微生物致病(Maria Hadjifrangisou博士)和临床病理学/实验室医学(Dr. 乔纳森·施密茨)，并得到地方执行委员会和外部咨询委员会的进一步支持。 这些小组同样将包括来自信息学家、传染病专家、 医院流行病学家和微生物专家，为VUIR提供持续的主题指导 该计划将对不同领域做出贡献。AdCore还将包括专门的后勤支持 来自在学术和财务管理方面具有广泛背景的专业人士以及网站 设计和活动管理。总的来说，这个小组将确保我们的后勤行动都是积极主动的 和响应性，协调互动，在范德比尔特内外传播标本/数据。这个 AdCore将在VUIR和精准医疗的补充机构结构之间创造协同效应 和翻译发现，以及基于VUIR资源的冠军试点项目。我们的最终目标是， 然而，是要在美国各地建立一个附属合作者、临床医生和研究人员的网络 他们既可以从数据和样本的综合财富中受益，也可以为其做出贡献。最后，除了 支持科学创新，AdCore将确保我们在教育和教育领域形成相应的足迹 服务。通过研讨会、研讨会和身临其境的体验相结合，我们将在全国范围内 从本科生到博士后/临床的不同受训人员的泌尿生殖系统感染生物学专家 伙计们。除了内容领域的教育，这些互动还将促进网络和职业发展 经验，包括来自代表性不足群体的个人的机会。以及更远的地方 在学术界，AdCore将在现有Vanderbilt项目的基础上，促进与更大社区的接触 让公众了解我们的科学使命。这样，VUIR的这一行政基础将 最大限度地提高该计划产生发现的能力，同时向广泛和多样化的人传播信息 观众。

SUMMARY - ADMINISTRATIVE CORE We propose the Vanderbilt Urologic Infection Repository (VUIR) as a first-in-kind resource for host-pathogen discovery, one that systematically connects [1] medical data from a vast number of patients who suffer from urinary tract infections (UTIs) to [2] a biobank of the actual causative organisms. As an informatic and biologic network, the VUIR will facilitate novel diagnostic and therapeutic strategies to combat UTIs, while providing a tool to elucidate their underlying pathogenesis. At the same time—given the extensive scope of the VUIR and its potential for multidisciplinary innovation—the need arises for a strong administrative foundation to coordinate the program's daily activities and bring to fruition its scientific vision. To these ends, a critical strength of the VUIR will be its associated Administrative Core (AdCore), a defined personnel structure for organizational success. The faculty leadership team of the AdCore holds broad expertise in clinical urology (Dr. Douglass Clayton), microbial pathogenesis (Dr. Maria Hadjifrangiskou), and clinical pathology/laboratory medicine (Dr. Jonathan Schmitz), further supported by both a Local Executive Committee and External Advisory Committee. These groups will likewise include strategic representation from informaticians, infectious disease specialists, hospital epidemiologists, and microbiome experts, providing ongoing thematic direction to the VUIR from the diverse fields to which the program will contribute. The AdCore will also incorporate dedicated logistical support from professionals with extensive background in academic and financial administration, as well as web-site design and event management. In total, this group will ensure that our logistical operations are both proactive and responsive, coordinating interactions and disseminating specimens/data within and beyond Vanderbilt. The AdCore will create synergy between the VUIR and complementary institutional structures for precision medicine and translational discovery, as well as champion pilot projects that build upon VUIR resources. Our ultimate goal, however, is to create a network of affiliated collaborators across the United States, clinicians and investigators who could both benefit from and contribute to the combined wealth of data and specimens. Finally, in addition to supporting scientific innovations, the AdCore will ensure we develop a concomitant footprint in education and service. Through a combination of workshops, seminars, and immersive experiences, we will connect nationwide experts in urogenital infection-biology to diverse trainees, from undergraduate students to postdoctoral/clinical fellows. In addition to content-area education, these interactions will foster networking and career-development experiences, including opportunities for individuals from underrepresented groups. And reaching beyond academia, the AdCore will promote outreach to the larger community, building on existing Vanderbilt programs to educate the public on our scientific mission. In this way, this administrative foundation of the VUIR will maximize the program's ability to generate discoveries, while disseminating information to broad and varied audiences.