HIV DART and Emerging Viruses: Frontiers in Drug Development and Antiretroviral Therapies

摘要/项目摘要 由于抗逆转录病毒疗法的进步，艾滋病毒和艾滋病的面貌已逐渐得到改善， 从一种致命的疾病转变成一种慢性疾病， 并严格遵守终身治疗方案。需要改进药物， 副作用，改善的依从性和更有利的药代动力学随着数量的增加而增加 接受长期治疗的受感染者人数继续上升。重要的是，对艾滋病毒的追求 随着我们对病毒库和病毒感染机制的了解越来越多， 病毒持久性HIV DART和新出现的病毒是两年一度的医生会议， 临床医生，护士，科学家和临床研究人员，将集中在最新的发现， 这些地区 具体目标：1。聚集跨学科的专业人士，如临床医生，医疗保健 工作人员、研究人员和基础科学家在互动研讨会上分享 并讨论艾滋病毒和新兴病毒领域的最新进展; 2.促进 中立和平衡地交流有关抗病毒药物科学知识 发展，疫苗开发，以及治疗策略的最新进展; 3.增强 培训研究生和博士后等青年科学家， 为代表性不足的科学家和卫生保健工作者提供更多机会， 参加奖学金。教育目标：1。识别新的治疗剂和病毒 艾滋病毒、逆转录病毒和其他新兴病毒的靶点; 2.了解艾滋病毒宿主和病毒 持久性; 3.讨论新的缓解，治愈和根除艾滋病毒的策略; 4。讨论 炎症在艾滋病毒感染，神经艾滋病和艾滋病的背景下，在老年人和儿童 人口; 5.了解药物代谢和药理学，并讨论改善 制剂; 6.讨论治疗途径、治疗即预防和杀微生物剂的作用; 7.讨论在合并感染B型肝炎或丙型肝炎病毒的情况下的艾滋病毒治疗; 8. 讨论疫苗开发和系统血清学的最新进展; 9.讨论最近 关于埃博拉、寨卡、基孔肯雅热等新出现的病毒威胁的科学发现， 登革热和黄热病。设计与方法：HIV DART和新出现的病毒将在 在美利坚合众国，在2.5天的时间内，在一个双方都很容易到达的地点， 国家和国际代表。该计划将包括全体讲座，口头摘要 演讲、小组讨论和辩论。该ACCME认证计划将提供 在会议期间，代表们有充分的时间进行正式和非正式的联系和讨论， 海报展示会和用餐时间。

Abstract/Project Summary Thanks to advances in antiretroviral therapy, the face of HIV and AIDS has been gradually and meaningfully transformed from a deadly disease, into a chronic condition that is managed with careful adherence to life-long treatment regimens. The need for improved drugs, with fewer side-effects, improved adherence and more favorable pharmacokinetics increases as the number of infected individuals on long-term therapy continues to rise. Importantly, the quest for an HIV cure continues to gain momentum as we learn more about viral reservoirs and mechanisms of viral persistence. HIV DART and Emerging Viruses is a biennial conference for physicians, clinicians, nurses, scientists and clinical researchers that will focus on the latest discoveries in these areas. Specific Aims: 1. Gather cross-disciplinary professionals such as clinicians, health care workers, researchers and basic scientists together in an interactive workshop setting to share and discuss the latest developments in the field of HIV and emerging viruses; 2. Facilitate the neutral and balanced exchange of scientific knowledge with regard to antiviral drug development, vaccine development, and recent progress in curative strategies; 3. Enhance the training of young scientists such as graduate students and post-doctoral fellows and provide increased opportunities for underrepresented scientists and health care workers through attendee scholarships. Educational Objectives: 1. Identify novel therapeutic agents and viral targets for HIV, retroviruses and other emerging viruses; 2. Understand HIV reservoirs and viral persistence; 3. Discuss novel remission, cure, and eradication strategies for HIV; 4. Discuss inflammation in the context of HIV infection, neuroAIDS and AIDS in geriatric and pediatric populations; 5. Understand drug metabolism and pharmacology and discuss improved formulations; 6. Discuss treatment access, treatment as prevention and the role of microbicides; 7. Discuss HIV treatment in the context of co-infection with Hepatitis B or hepatitis C virus; 8. Discuss recent advances in vaccine development and systems serology; 9. Discuss recent scientific discoveries with regard to emerging viral threats such as Ebola, Zika, chikungunya, dengue and yellow fever. Design & Methods: HIV DART and Emerging Viruses will take place in the United States of America over a 2.5 days period, at a location that is easily accessed by both national and international delegates. The program will include plenary lectures, oral abstract presentations, discussion panels and a debate. This ACCME-accredited program will provide ample time for formal and informal networking and discussion amongst the delegates during the poster session and meal breaks.