Protective roles of taurine in Alzheimer's disease brain

摘要 本项目将研究饮食中牛磺酸的保护作用和机制。 在阿尔茨海默病(AD)小鼠模型中补充。我们将衡量 牛磺酸在脑内的摄取和牛磺酸合成速率 磁共振波谱(MRS)。然后，我们将确定多少钱 牛磺酸膳食补充剂(不同剂量)可预防 阿尔茨海默病(AD)小鼠模型中阿尔茨海默病症状的进展。这个 将使用一组体内成像标记(MRI，MRS， 正电子发射断层扫描(PET)、行为测试和死后标记 神经炎症、AD病理和神经化学(MRS)取自同一 老鼠。然后，将在人脑中进行同样的尸检测量 来自脑库的组织具有非常好的特征样本，包括健康的 对照组、轻度认知障碍和经病理证实的阿尔茨海默病 疾病。项目的最终结果应该是更好地理解 大脑中的牛磺酸，以及对一种新疗法的良好测试，这种疗法也可以在 活生生的人脑(一种“火药”)。这种化合物应该很容易翻译成 由于在运动员中广泛使用它作为一种饮食 副刊。

Abstract This project will examine the protective effects and mechanisms of dietary taurine supplementation in a mouse model of Alzheimer’s disease (AD). We will measure taurine uptake into the brain and taurine synthesis rates using labeled taurine and magnetic resonance spectroscopy (MRS). Then, we will determine how much protection taurine dietary supplementation (at various doses) provides against progression of Alzheimer’s disease (AD) symptoms in an AD mouse model. The protection will be measured using a battery of in vivo imaging markers (MRI, MRS, positron emission tomography (PET), behavioral tests and post mortem markers of neuroinflammation, AD pathology and neurochemistry (MRS) taken from the same mice. Then, the same post mortem measurements will be made in human brain tissue from a brain bank with very well characterized specimens including healthy controls, mild cognitive impairment and pathologically confirmed Alzheimer’s disease. The end result of the project should be a better understanding of the role of taurine in the brain and good test of a novel therapeutic that can also be detected in live human brain (a “theranostic”). This compound should be readily translatable to human populations due to its widespread use among athletes as a dietary supplement.