Protective roles of taurine in Alzheimer's disease brain
牛磺酸对阿尔茨海默病大脑的保护作用
基本信息
- 批准号:10055586
- 负责人:
- 金额:$ 233.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgingAlzheimer&aposs DiseaseAlzheimer&aposs disease brainAlzheimer&aposs disease modelAlzheimer&aposs disease pathologyAmino AcidsAmyloid beta-ProteinAnti-Inflammatory AgentsAreaAutopsyBehaviorBenignBrainBrain DiseasesBrain regionComplementCysteineDataDevelopmentDietDietary SupplementationDisease MarkerDisease ProgressionDoseEconomic BurdenEtiologyGlial Fibrillary Acidic ProteinGrantHippocampus (Brain)HumanImaging TechniquesIn VitroIncidenceInflammationInflammatoryInterleukin-1LabelLife StyleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMetabolicMetabolismMicrogliaMusNeuronsOsmoregulationPathologicPathology ReportPharmacologyPlasmaPlayPopulationPositron-Emission TomographyProcessPropertyRoleSocietiesSpecimenStainsStrokeSupplementationSymptomsTaurineTechniquesTestingTherapeutic EffectTissue SampleTissuesTraumatic Brain Injuryage related neurodegenerationbehavior testbrain tissuecohortcytokinedietary supplementsfamily burdenimaging biomarkerin vivoin vivo imaginginflammatory markerinflammatory modulationmicroPETmild cognitive impairmentmouse modelneurochemistryneuroinflammationneuropathologynovel therapeuticspreventprotective effectside effecttheranosticstranslation to humanstranslational studyuptakewater maze
项目摘要
Abstract
This project will examine the protective effects and mechanisms of dietary taurine
supplementation in a mouse model of Alzheimer’s disease (AD). We will measure
taurine uptake into the brain and taurine synthesis rates using labeled taurine and
magnetic resonance spectroscopy (MRS). Then, we will determine how much
protection taurine dietary supplementation (at various doses) provides against
progression of Alzheimer’s disease (AD) symptoms in an AD mouse model. The
protection will be measured using a battery of in vivo imaging markers (MRI, MRS,
positron emission tomography (PET), behavioral tests and post mortem markers of
neuroinflammation, AD pathology and neurochemistry (MRS) taken from the same
mice. Then, the same post mortem measurements will be made in human brain
tissue from a brain bank with very well characterized specimens including healthy
controls, mild cognitive impairment and pathologically confirmed Alzheimer’s
disease. The end result of the project should be a better understanding of the role of
taurine in the brain and good test of a novel therapeutic that can also be detected in
live human brain (a “theranostic”). This compound should be readily translatable to
human populations due to its widespread use among athletes as a dietary
supplement.
摘要
本计画将探讨饮食中牛磺酸的保护作用与机制
在阿尔茨海默氏病(AD)的小鼠模型中,我们将测量
使用标记的牛磺酸,
磁共振波谱(MRS)。然后,我们将确定
保护牛磺酸膳食补充剂(以不同剂量)提供,
在AD小鼠模型中阿尔茨海默病(AD)症状的进展。的
将使用一组体内成像标记物(MRI,MRS,
正电子发射断层扫描(PET),行为测试和死后标志物,
神经炎症、AD病理学和神经化学(MRS)取自相同的
小鼠然后,同样的死后测量将在人类大脑中进行
来自脑库的组织,具有非常好的特征化标本,包括健康的
对照组,轻度认知障碍和病理证实的阿尔茨海默氏症
疾病该项目的最终结果应该是更好地了解
牛磺酸在大脑和良好的测试一种新的治疗,也可以检测到,
活的人脑(“治疗诊断学”)。这个复合词应该很容易翻译成
由于其在运动员中广泛使用,
补充.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ALPASLAN DEDEOGLU', 18)}}的其他基金
Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis
1-磷酸鞘氨醇系统作为肌萎缩侧索硬化症的治疗靶点
- 批准号:
10011983 - 财政年份:2021
- 资助金额:
$ 233.73万 - 项目类别:
Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis
1-磷酸鞘氨醇系统作为肌萎缩侧索硬化症的治疗靶点
- 批准号:
10664897 - 财政年份:2021
- 资助金额:
$ 233.73万 - 项目类别:
Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis
1-磷酸鞘氨醇系统作为肌萎缩侧索硬化症的治疗靶点
- 批准号:
10476986 - 财政年份:2021
- 资助金额:
$ 233.73万 - 项目类别:
Targeting the sphingosine-1-phosphate system in a mouse model of Gulf War Veterans' Illness
针对海湾战争退伍军人疾病小鼠模型中的 1-磷酸鞘氨醇系统
- 批准号:
10293531 - 财政年份:2020
- 资助金额:
$ 233.73万 - 项目类别:
Targeting the sphingosine-1-phosphate system in a mouse model of Gulf War Veterans' Illness
针对海湾战争退伍军人疾病小鼠模型中的 1-磷酸鞘氨醇系统
- 批准号:
9891211 - 财政年份:2020
- 资助金额:
$ 233.73万 - 项目类别:
Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease
1-磷酸鞘氨醇诱导衰老和阿尔茨海默病炎症的调节
- 批准号:
9403429 - 财政年份:2017
- 资助金额:
$ 233.73万 - 项目类别:
Novel neurotrophic therapies in an optimized mouse model of GWVI
优化的 GWVI 小鼠模型中的新型神经营养疗法
- 批准号:
8815008 - 财政年份:2014
- 资助金额:
$ 233.73万 - 项目类别:
Novel neurotrophic therapies in an optimized mouse model of GWVI
优化的 GWVI 小鼠模型中的新型神经营养疗法
- 批准号:
8974377 - 财政年份:2014
- 资助金额:
$ 233.73万 - 项目类别:
Novel neurotrophic therapies in an optimized mouse model of GWVI
优化的 GWVI 小鼠模型中的新型神经营养疗法
- 批准号:
8660378 - 财政年份:2014
- 资助金额:
$ 233.73万 - 项目类别:
Novel neurotrophic therapies in an optimized mouse model of GWVI
优化的 GWVI 小鼠模型中的新型神经营养疗法
- 批准号:
9339554 - 财政年份:2014
- 资助金额:
$ 233.73万 - 项目类别: