Protective roles of taurine in Alzheimer's disease brain

牛磺酸对阿尔茨海默病大脑的保护作用

• 批准号: 10055586
• 负责人: ALPASLAN DEDEOGLU
• 金额: $ 233.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10055586
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease model; Alzheimer' s disease pathology; Amino Acids; Amyloid beta-Protein; Anti-Inflammatory Agents; Area; Autopsy; Behavior; Benign; Brain; Brain Diseases; Brain region; Complement; Cysteine; Data; Development; Diet; Dietary Supplementation; Disease Marker; Disease Progression; Dose; Economic Burden; Etiology; Glial Fibrillary Acidic Protein; Grant; Hippocampus (Brain); Human; Imaging Techniques; In Vitro; Incidence; Inflammation; Inflammatory; Interleukin-1; Label; Life Style; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolic; Metabolism; Microglia; Mus; Neurons; Osmoregulation; Pathologic; Pathology Report; Pharmacology; Plasma; Play; Population; Positron-Emission Tomography; Process; Property; Role; Societies; Specimen; Stains; Stroke; Supplementation; Symptoms; Taurine; Techniques; Testing; Therapeutic Effect; Tissue Sample; Tissues; Traumatic Brain Injury; age related neurodegeneration; behavior test; brain tissue; cohort; cytokine; dietary supplements; family burden; imaging biomarker; in vivo; in vivo imaging; inflammatory marker; inflammatory modulation; microPET; mild cognitive impairment; mouse model; neurochemistry; neuroinflammation; neuropathology; novel therapeutics; prevent; protective effect; side effect; theranostics; translation to humans; translational study; uptake; water maze

Abstract This project will examine the protective effects and mechanisms of dietary taurine supplementation in a mouse model of Alzheimer’s disease (AD). We will measure taurine uptake into the brain and taurine synthesis rates using labeled taurine and magnetic resonance spectroscopy (MRS). Then, we will determine how much protection taurine dietary supplementation (at various doses) provides against progression of Alzheimer’s disease (AD) symptoms in an AD mouse model. The protection will be measured using a battery of in vivo imaging markers (MRI, MRS, positron emission tomography (PET), behavioral tests and post mortem markers of neuroinflammation, AD pathology and neurochemistry (MRS) taken from the same mice. Then, the same post mortem measurements will be made in human brain tissue from a brain bank with very well characterized specimens including healthy controls, mild cognitive impairment and pathologically confirmed Alzheimer’s disease. The end result of the project should be a better understanding of the role of taurine in the brain and good test of a novel therapeutic that can also be detected in live human brain (a “theranostic”). This compound should be readily translatable to human populations due to its widespread use among athletes as a dietary supplement.

摘要 本计画将探讨饮食中牛磺酸的保护作用与机制 在阿尔茨海默氏病（AD）的小鼠模型中，我们将测量 使用标记的牛磺酸， 磁共振波谱（MRS）。然后，我们将确定 保护牛磺酸膳食补充剂（以不同剂量）提供， 在AD小鼠模型中阿尔茨海默病（AD）症状的进展。的 将使用一组体内成像标记物（MRI，MRS， 正电子发射断层扫描（PET），行为测试和死后标志物， 神经炎症、AD病理学和神经化学（MRS）取自相同的 小鼠然后，同样的死后测量将在人类大脑中进行 来自脑库的组织，具有非常好的特征化标本，包括健康的 对照组，轻度认知障碍和病理证实的阿尔茨海默氏症 疾病该项目的最终结果应该是更好地了解 牛磺酸在大脑和良好的测试一种新的治疗，也可以检测到， 活的人脑（“治疗诊断学”）。这个复合词应该很容易翻译成 由于其在运动员中广泛使用， 补充.