New role for the E3 ligase E6AP in the control of cell motility and invasion

E3连接酶E6AP在控制细胞运动和侵袭中的新作用

• 批准号: nhmrc : 1049179
• 负责人: Dr Mariam Mansour
• 金额: $ 30.82万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-role-e3-motility-invasion/112062
• 关键词: New; role; E3; ligase; E6AP

Cell motility and invasion are fundamental process in normal cellular functions, however, when deregulated they can lead to metastatic cancer, a leading cause of cancer mortality and morbidity worldwide. Detailed understanding of the mechanisms governing these processes is essential for the development of new targets to prevent metastatic cancer. We discovered a protein that control these processes, which renders it an important target to investigate.

细胞运动和侵袭是正常细胞功能的基本过程，然而，当它们被解除调节时，它们可导致转移性癌症，这是全球癌症死亡率和发病率的主要原因。详细了解这些过程的机制对于开发预防转移性癌症的新靶点至关重要。我们发现了一种控制这些过程的蛋白质，这使得它成为一个重要的研究目标。