用于具有单细胞空间分辨率的组织样本多组学分析的通用高通量平台-猫眼课题宝

用于具有单细胞空间分辨率的组织样本多组学分析的通用高通量平台

批准号：

10081014

负责人：

Boris Gorbovitski

金额：

$40.0万

依托单位：

SOMAGENE, INC.

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-07-01 至 2022-06-30

来源：

https://reporter.nih.gov/project-details/10081014

关键词：

Address Bar Codes Binding Sites Biological Biological Assay Biological Sciences Biological Testing Blood capillaries Cancer Patient Cells Chemicals Cleaved cell Clinical Trials Communicable Diseases Complementary DNA Complex DNA DNA amplification DNA sequencing Data Deposition Detection Development Disease Dissociation Dropout Electroporation Elements Epigenetic Process Evolution Gel Gene Expression Profiling Genes Genetic Genetic Transcription Genomics Glass Goals Health Human Hybrids Image Immune Individual Injections Kinetics Liquid substance Malignant Neoplasms Measurable Messenger RNA Methods Molecular New York Phase Population Positioning Attribute Probability Process Program Development Protocols documentation Quality Control RNA Resolution Reverse Transcription Sampling Slide Small Business Technology Transfer Research Solid Neoplasm Stains Surface System Techniques Technology Testing Tissue Sample Tissue imaging Tissues Transcript Universities Validation Variant Visualization base cancer cell cancer type cell type clinical practice computerized data processing cost design experimental study foot genetic profiling high throughput technology indexing innovation medical schools multiple omics nano novel novel strategies personalized cancer therapy personalized diagnostics research and development single cell analysis single cell technology stem cells success surface coating technology development tool transcriptomics tumor tumor progression

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中文摘要

翻译

摘要单细胞分析技术的发展对人类健康产生了重大影响。目前，约有1，300项临床试验正在进行中，以引入单细胞分析。各种癌症和传染病的临床实践。建议的目标 STTR项目是开发一个高通量的转录组学平台，在单细胞和亚细胞水平上具有空间分辨率的潜力。

英文摘要

ABSTRACT The development of technologies for single-cell analysis has strong impact on human health. Currently, around 1,300 clinical trials are in process to introduce the single-cell analysis in clinical practice for various types of cancer and infectious diseases. The goal of the proposed STTR project is the development of a high-throughput transcriptomic platform with multi-omic potential with spatial resolution at a single-cell and sub-cellular level.

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