Universal, high-throughput platform for multi-omic analysis of tissue samples with single-cell spatial resolution

用于具有单细胞空间分辨率的组织样本多组学分析的通用高通量平台

• 批准号: 10081014
• 负责人: Boris Gorbovitski
• 金额: $ 40万
• 依托单位: SOMAGENE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081014
• 关键词: Address; Bar Codes; Binding Sites; Biological; Biological Assay; Biological Sciences; Biological Testing; Blood capillaries; Cancer Patient; Cells; Chemicals; Cleaved cell; Clinical Trials; Communicable Diseases; Complementary DNA; Complex; DNA; DNA amplification; DNA sequencing; Data; Deposition; Detection; Development; Disease; Dissociation; Dropout; Electroporation; Elements; Epigenetic Process; Evolution; Gel; Gene Expression Profiling; Genes; Genetic; Genetic Transcription; Genomics; Glass; Goals; Health; Human; Hybrids; Image; Immune; Individual; Injections; Kinetics; Liquid substance; Malignant Neoplasms; Measurable; Messenger RNA; Methods; Molecular; New York; Phase; Population; Positioning Attribute; Probability; Process; Program Development; Protocols documentation; Quality Control; RNA; Resolution; Reverse Transcription; Sampling; Slide; Small Business Technology Transfer Research; Solid Neoplasm; Stains; Surface; System; Techniques; Technology; Testing; Tissue Sample; Tissue imaging; Tissues; Transcript; Universities; Validation; Variant; Visualization; base; cancer cell; cancer type; cell type; clinical practice; computerized data processing; cost; design; experimental study; foot; genetic profiling; high throughput technology; indexing; innovation; medical schools; multiple omics; nano; novel; novel strategies; personalized cancer therapy; personalized diagnostics; research and development; single cell analysis; single cell technology; stem cells; success; surface coating; technology development; tool; transcriptomics; tumor; tumor progression

ABSTRACT The development of technologies for single-cell analysis has strong impact on human health. Currently, around 1,300 clinical trials are in process to introduce the single-cell analysis in clinical practice for various types of cancer and infectious diseases. The goal of the proposed STTR project is the development of a high-throughput transcriptomic platform with multi-omic potential with spatial resolution at a single-cell and sub-cellular level.

摘要 单细胞分析技术的发展对人类健康产生了重大影响。 目前，约有1，300项临床试验正在进行中，以引入单细胞分析。 各种癌症和传染病的临床实践。建议的目标 STTR项目是开发一个高通量的转录组学平台， 在单细胞和亚细胞水平上具有空间分辨率的潜力。