Core A: Administrative Core

项目摘要：核心A 核心A是PPG及其所有组件的管理和临床采购核心。这个PPG 包括血液研究所、安大略省金斯敦、都柏林和 专注于von Willebrand因子(VWF)的生物学和机制 导致血管性血友病(VWD)。目标1是有效地处理 4个项目和3个核心。核心A将安排委托人之间的定期(每月)电话会议 调查人员以及在ASH和ISTH举行的两次面对面会议。AIM 2将有效地处理 临床采集样本，维护生物库，确保样本的完整性和保密性 数据库。它还将处理将DNA或血浆样本从密尔沃基中心运往 有选择的项目(1、2、3和4)以及核心B和C核心A也将保持开放和有效 与所有协作中心的行政和财务负责人进行沟通 国家卫生研究院。

PROJECT SUMMARY: CORE A Core A is the Administrative and Clinical Acquisition Core for the PPG and all of its components. This PPG includes outstanding scientists within the Blood Research Institute and in Kingston Ontario, Dublin, and the University of Colorado, that are tightly focused on the biology of von Willebrand factor (VWF) and mechanisms causing von Willebrand Disease (VWD). Aim 1 is to effectively handle the administrative interactions between the 4 projects and 3 cores. Core A will schedule the periodic (monthly) conference calls between principal investigators as well as the two in-person meetings held at ASH and ISTH. Aim 2 will efficiently handle the clinical acquisition of samples, maintain the biorepository, assure the integrity and confidentiality of the database. It will also handle the shipment of DNA or plasma samples from the Milwaukee center to the selective projects (1, 2, 3, and 4) and Cores B and C. Core A will also maintain open and effective communication with the administrative and fiscal responsible personnel at all of the collaborating centers and NIH.