The Cause of Systemic Inflammatory Response during Cardiopulmonary Bypass and Prevention by Nitric Oxide

摘要 全身炎症反应和器官衰竭(SIRS-CPB)是心脏手术后的主要问题。 其发生率随体外循环时间的延长而增加。其机制尚不清楚。我们的 初步研究表明，体外循环期间暴露于表面的白细胞激活是原因。我们的研究 说明进入心肺机的气体中的一氧化氮(NO)可以阻止白细胞的激活。 本研究旨在确定SIRS-CPB的原因及NO的预防。

Abstract Systemic Inflammatory Response and organ failure (SIRS-CPB) is a major problem following cardiac surgery. The incidence increases with the amount of time on cardiopulmonary bypass. The mechanism is unknown. Our preliminary studies indicate that white cell activation by surface exposure during CPB is the cause. Our studies indicate that the white cell activation can be prevented by nitric oxide (NO) in the gas to the heart/lung machine. This research is designed to determine the cause of SIRS-CPB and prevention with NO.