The Cause of Systemic Inflammatory Response during Cardiopulmonary Bypass and Prevention by Nitric Oxide

体外循环期间全身炎症反应的原因及一氧化氮的预防

• 批准号: 10113414
• 负责人: Alvaro Rojas-Pena
• 金额: $ 63.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10113414
• 关键词: Air; Animal Model; Automation; Back; Blood; Blood Platelets; Cardiac; Cardiac Surgery procedures; Cardiopulmonary Bypass; Child; Clinical; Clinical Medicine; Clinical Research; Clinical Trials; Complex; Development; Devices; Dose; Elements; Exposure to; Family suidae; Future; Gases; Grant; Heart-Lung Machine; Incidence; Inflammation; Injury; Intervention; Kidney; Laboratories; Laboratory Study; Leukocytes; Location; Lung; Modeling; Nitric Oxide; Organ failure; Patients; Pharmaceutical Preparations; Platelet Activation; Prevention; Research; Source; Suction; Surface; Syndrome; System; Testing; Time; cost; design; operation; organ injury; porcine model; prevent; response; systemic inflammatory response

Abstract Systemic Inflammatory Response and organ failure (SIRS-CPB) is a major problem following cardiac surgery. The incidence increases with the amount of time on cardiopulmonary bypass. The mechanism is unknown. Our preliminary studies indicate that white cell activation by surface exposure during CPB is the cause. Our studies indicate that the white cell activation can be prevented by nitric oxide (NO) in the gas to the heart/lung machine. This research is designed to determine the cause of SIRS-CPB and prevention with NO.

摘要 全身炎症反应和器官衰竭（SIRS-CPB）是心脏手术后的主要问题。 发生率随着体外循环时间的增加而增加。其机制尚不清楚。我们 初步研究表明，CPB期间表面暴露引起的白色细胞活化是原因。我们的研究 表明白色细胞活化可以通过进入心肺机的气体中的一氧化氮（NO）来防止。 本研究旨在探讨SIRS-CPB的病因及NO的预防作用。