New strategies to target multiple drug resistance in clinically relevant fungal infections.

针对临床相关真菌感染的多重耐药性的新策略。

• 批准号: nhmrc : 1090444
• 金额: $ 25.27万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-strategies-target-fungal-infections/519284
• 关键词: New; strategies; target; multiple; drug

The emergence of multiple drug resistance (MDR) in the community and hospitals is considered a major threat to public health. Fungal bloodstream infections with opportunistic Candida species are of particular concern. Azoles are the most widely used class of antifungals in clinical use, but their efficacy is severely limited by the development of MDR. This project will employ a comprehensive, cross-disciplinary approach to develop novel small-molecule therapeutics for combatting fungal MDR.

社区和医院出现多重耐药(MDR)被认为是对公共卫生的重大威胁。机会性念珠菌引起的真菌血流感染尤其令人担忧。咪唑类药物是临床上应用最广泛的一类抗真菌药物，但其疗效受到MDR发展的严重限制。该项目将采用一种综合的、跨学科的方法来开发对抗真菌MDR的新型小分子疗法。