Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
基本信息
- 批准号:10117836
- 负责人:
- 金额:$ 75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-24 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAnatomic ModelsAnatomyAtlasesBasic ScienceBenignBiological AssayCell CommunicationCellsCellular biologyCervicalCharacteristicsChromatinClinicalComplexDataDepositionDiscipline of obstetricsEndometrialEnsureEquilibriumExperimental DesignsFertilityGenerationsGoalsGynecologicGynecologyHealthHuman BioMolecular Atlas ProgramHuman BiologyImageIndividualInformaticsInformation SystemsLocationMalignant NeoplasmsMammalian OviductsMapsMeasurementMetadataModelingMolecularOperative Surgical ProceduresOrganOrganoidsOvaryPennsylvaniaPhysiologicalProceduresProcessProphylactic treatmentProtocols documentationQuality ControlRNARadiology SpecialtyReagentRecordsReproductive HealthReproductive MedicineReproductive systemResearchResearch PersonnelResearch SubjectsResourcesRiskSamplingSiteSterilizationStructureSystemTherapeuticTimeTissue SampleTissuesTransplantationUnited StatesUniversitiesUterusWomen&aposs HealthWorkblastocystcell communitycomputational pipelinescostdata sharingdigitalfemale reproductive systemhuman femaleindexingindividual variationmembermolecular scalemultimodalityprogramssingle moleculesingle-cell RNA sequencingstructured datatranscriptomics
项目摘要
The female reproductive system, the uterus, fallopian tubes and the ovaries, is a complex interrelated set
of organs that is physiologically dynamic and not only important for fertility but critically interrelated with
general health. Single cell studies of the human female reproductive system and related tissues have
been previously studied, but, as of yet, a comprehensive program, aligned with the goals of the
HuBMAP, to define a molecular map of the entire system, integrating multi-modal assays, spatial
diversity, and individual variations has not been established. The Penn Department of Obstetrics and
Gynecology performs approximately 3,500 surgical procedures annually, of which many procedures
allow sampling of multiple organs and locations from the same subject under normal conditions. Here,
we propose to leverage the sampling opportunities afforded by the Penn ObGyn group and the single
cell biology expertise of Penn investigators to establish a Penn Center for Multi-scale Molecular Map of
the Female Reproductive System. We will obtain a comprehensive molecular characterization of the
female reproductive system using six different molecular assays for at least ~700 tissue samples in
anatomically indexed samples, creating a key resource for both basic science and women’s health. The
molecular assays include single cell RNAseq, clampFISH spatial transcriptomics, simultaneous single
cell open chromatin and RNA assays, and spatial open chromatin assay, among others. We will also
generate a 3D anatomical model to provide spatial coordinate for our molecular characterization. All
assay data will be registered to our 3D anatomical map that will be integrated with the HIVE Common
Coordinate Framework. All metadata from subject records, clinical procedures, molecular procedures,
and informatics pipelines will be collected, curated, and deposited as structured data. All data, including
an extensive set of metadata, will be made available as a public resource. The completion of this
resource will impact reproductive medicine for women’s health and also inform basic biology of human
cell communities.
女性生殖系统,子宫,输卵管和卵巢,是一个复杂的相互关联的集合
项目成果
期刊论文数量(0)
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JUNHYONG KIM其他文献
JUNHYONG KIM的其他文献
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{{ truncateString('JUNHYONG KIM', 18)}}的其他基金
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10413658 - 财政年份:2020
- 资助金额:
$ 75万 - 项目类别:
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10269925 - 财政年份:2020
- 资助金额:
$ 75万 - 项目类别:
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10461161 - 财政年份:2020
- 资助金额:
$ 75万 - 项目类别:
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10653357 - 财政年份:2020
- 资助金额:
$ 75万 - 项目类别:
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10822203 - 财政年份:2020
- 资助金额:
$ 75万 - 项目类别:
High performance IBM iDataPlex/SONAS computing cluster for genomics
用于基因组学的高性能 IBM iDataPlex/SONAS 计算集群
- 批准号:
8334809 - 财政年份:2013
- 资助金额:
$ 75万 - 项目类别: