An AHEI Dietary Intervention to Reduce Pain in Women with Endometriosis

AHEI 饮食干预可减轻子宫内膜异位症女性的疼痛

• 批准号: 10078876
• 负责人: Holly Ruth Harris
• 金额: $ 12.18万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-11 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10078876
• 关键词: Abate; Adherence; Affect; Age; Alternative Health; Analgesics; Bed Occupancy; Bed rest; Behavioral; Biological Markers; C-reactive protein; Carotenoids; Control Groups; Diagnosis; Diet; Diet Modification; Dietary Factors; Dietary Intervention; Dietitian; Disease; Educational process of instructing; Effectiveness; Endometrial; Etiology; Food; Foundations; Goals; Guidelines; Health; Health Care Costs; Healthy Eating; Home; Hormonal; Individual; Infertility; Inflammation; Inflammatory; Instruction; Interleukin-1 beta; Interleukin-6; Interleukins; Intervention; Measures; Metabolism; Morbidity - disease rate; National Health Interview Survey; Nurses' Health Study; Observational Study; Operative Surgical Procedures; Outcome; Pain; Pain quality; Participant; Pelvic Pain; Persons; Plasma; Play; Premenopause; Preparation; Prevalence; Process; Productivity; Prostaglandins; Psyche structure; Publications; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Recipe; Records; Reporting; Research; Risk; Risk Factors; Role; Ships; Smooth Muscle; Surveys; Symptoms; TNFRSF1A gene; Telephone; Testing; Tissues; Training; Uterine cavity; Uterus; Visual; Visual Analogue Pain Scale; Woman; Work; aged; analog; base; biobank; chronic pelvic pain; cost; cytokine; dietary; dietary guidelines; dietary supplements; endometriosis; evidence base; experience; group intervention; improved; indexing; inflammatory marker; intervention effect; meetings; modifiable risk; pain catastrophizing; pain reduction; pain score; pain symptom; phenome; pill; psychologic; randomized controlled design; reproductive; social; surgical pain; symptomatology

PROJECT SUMMARY/ABSTRACT Endometriosis, a disorder characterized by the presence of endometrial-like tissue outside of the uterus, affects approximately 10% of reproductive age women in the US. Despite its prevalence, the etiology of endometriosis has not been fully delineated. It incurs significant health care costs and greatly impacts quality of life (QOL). Over 80% of women with endometriosis report chronic pelvic pain (CPP) and symptoms are often not sufficiently abated with hormonal suppression or surgery. Hence, the identification of other evidenced- based, modifiable factors, that improve pain and QOL are critical to improving the lives of women with endometriosis. The goal of this study is to evaluate the effects of a 12-week dietary intervention among women with laparoscopically-confirmed endometriosis who had a pain score of at least 7 out of 10 on the Visual Analog Scale (VAS) in the month prior to baseline. The intervention will consist of a diet based on the Alternative Health Eating Index-2010 (AHEI-2010) guidelines, as observational research suggests that adherence to the AHEI-2010 may decrease risk of laparoscopically-diagnosed endometriosis among women experiencing pain symptoms. The specific aims of the proposed study are to test the effect of the AHEI-2010 guideline-based dietary intervention on: 1) the VAS pain score, the pain catastrophizing scale, and mean number of pain pills taken per week; 2) physical and mental QOL components measured with the Endometriosis Health Profile (EHP-30) Questionnaire and Short Form Survey (SF-12); 3) circulating levels of inflammatory markers (IL-6, IL- 1β, hs-CRP, sTNFR-1, sTNFR-2). Women with laparoscopically-confirmed endometriosis (n=100) will be randomized to a 12-week dietary intervention or a control group. The intervention group will have meal ingredients shipped to directly to their home during the first 4 weeks of the intervention. For the remaining 8 weeks, meal plans and recipes will be provided. Pain, quality of life, and inflammatory markers will be assessed at baseline, 4, 8, and 12-weeks using validated questionnaires following the guidelines of the World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonization Project (EPHect). In addition, longer-term effects of the intervention will be assessed by examining pain and QOL outcomes at 6 months and 1 year. Many women with endometriosis experience poor QOL due to chronic pelvic pain and other physical and mental sequelae of endometriosis. As symptoms are often not sufficiently abated with hormonal suppression or surgery, the identification of other evidenced-based, modifiable factors, that improve pain and QOL are critical to improving the lives of women with endometriosis.

项目总结/文摘