The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and Extinction
杏仁核中支持听觉恐惧调节(印迹)的神经元群在记忆形成、泛化和消退中的作用
基本信息
- 批准号:10087966
- 负责人:
- 金额:$ 33.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAmygdaloid structureAnxietyAnxiety DisordersArchitectureAuditoryBehaviorBrainCalciumCell NucleusCellsCodeDangerousnessDataDevelopmentDiseaseEndoscopesEventExtinction (Psychology)Fluorescent in Situ HybridizationFreezingFrightFutureHalorhodopsinsHippocampus (Brain)ImageImmediate-Early GenesLateralLeadLightMapsMediatingMemoryMental disordersMessenger RNAMicroscopyMusNeuronsNuclearOpsinPopulationPost-Traumatic Stress DisordersPrevention strategyProcessRecurrenceResearch PersonnelRetrievalRoleStimulusSystemTechniquesTestingTimeTissuesTrainingTraining ActivityVirusWild Type Mousebaseconditioned feardata analysis pipelineeffective therapyexperiencefear memorygraph theoryin vivo calcium imaginginnovationmachine learning algorithmmemory consolidationneuronal excitabilityoptogeneticspromoterrecruittherapy developmenttreatment strategy
项目摘要
Project Summary/Abstract
Memory may be defined as the retention over time of internal representations gained through
experience, and the capacity to reconstruct these representations at later times (Dudai 2007).
These internal representations are thought to be encoded by long-lasting physical brain
changes (memory traces or `engrams') (Josselyn, Kohler & Frankland 2015, 2017; Tonegawa et
al. 2015; Schacter 2001). Remembering fear-evoking events is adaptive; it helps one make
future choices based on past experience. It may even be beneficial to generalize some fearful
memories. However, excessive fear generalization or treating no-longer threatening stimuli as
dangerous may be maladaptive. Indeed, recurrent or inappropriately expressed fearful
memories are a major component of several psychiatric diseases, including post-traumatic
stress disorder (PTSD) and anxiety. Therefore, understanding how memory traces for fearful
events are formed, change over time, under what conditions they remain specific or generalize,
and how they are impacted by behavioral extinction are critical questions to not only
understanding how the brain uses information but also for informing the development of new
treatment/prevention strategies for disorders characterized by inappropriate fear memories.
Here two PIs (Drs. Josselyn and Frankland), both New Investigators, will combine their
expertise to address these important questions. Because all techniques are associated with
caveats and limitations, we will use a variety of techniques including optogenetic manipulation,
brain-wide neuronal activity mapping and the use of graph-theory to produce “engram maps”
and real time in vivo calcium imaging combined with behavior. Together, the ability to
manipulate and observe an engram as it forms, changes over time and with behavioral
extinction is innovative and may lead to a shift in the very definition of an engram, as well as
increase our understanding for developing treatments aimed at resolving inappropriate fear
memories.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sheena A Josselyn其他文献
mTORC2: actin on your memory
mTORC2:对您的记忆起作用
- DOI:
10.1038/nn.3362 - 发表时间:
2013-03-26 - 期刊:
- 影响因子:20.000
- 作者:
Sheena A Josselyn;Paul W Frankland - 通讯作者:
Paul W Frankland
Memory Allocation
内存分配
- DOI:
10.1038/npp.2014.234 - 发表时间:
2014-12-08 - 期刊:
- 影响因子:7.100
- 作者:
Paul W Frankland;Sheena A Josselyn - 通讯作者:
Sheena A Josselyn
Hippocampal Neurogenesis and Memory Clearance
海马神经发生与记忆清除
- DOI:
10.1038/npp.2015.243 - 发表时间:
2015-12-10 - 期刊:
- 影响因子:7.100
- 作者:
Paul W Frankland;Sheena A Josselyn - 通讯作者:
Sheena A Josselyn
Sheena A Josselyn的其他文献
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{{ truncateString('Sheena A Josselyn', 18)}}的其他基金
The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and Extinction
杏仁核中支持听觉恐惧调节(印迹)的神经元群在记忆形成、泛化和消退中的作用
- 批准号:
10553228 - 财政年份:2019
- 资助金额:
$ 33.78万 - 项目类别:
The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and Extinction
杏仁核中支持听觉恐惧调节(印迹)的神经元群在记忆形成、泛化和消退中的作用
- 批准号:
9891099 - 财政年份:2019
- 资助金额:
$ 33.78万 - 项目类别: